We defined a credible set of variants in each locus using the method described by Maller et al.123 (Supplementary Information), implemented by a freely available R script (see URLs). Under the assumption that (a) there is one causal variant in each locus, and (b) the causal variant is observed in the genotype data, the credible set can be considered to have a 99% probability of containing the causal variant. For each the 12 genome-wide significant loci, variants within 1MB and in LD with correlation r2 > 0.4 to the index variant were considered for inclusion in the credible set analysis. The credible set analysis was done using the European GWAS meta-analysis to ensure consistent LD structure in the analyzed cohorts.
