g/kg) dose of ethanol showed increased locomotor activity (PND 46) following repeated ethanol treatment during adolescence relative to saline-treated rats. This pattern persisted into young adulthood when animals were challenged with the same moderate dose of ethanol on PND 60 (Maldonado and Kirstein, unpublished data). Interestingly, behavioral sensitization has been observed in Sprague Dawley rats to a lower dose of ethanol when animals were separated into high and low responders to novelty (Hoshaw & Lewis 2001). These results again demonstrate repeated alcohol exposure during adolescence results in persistent alterations in behavior that last into young adulthood.
