The Acute Subjective Responses to Tobacco (PhenX (https://www.phenxtoolkit.org/) instrument has been modified from the adult version for purposes of this ABCD Study. The self-administered instrument assesses the participant’s subjective response to tobacco cigarette following first exposure. The assessment has been shown to be efficacious in capturing early smoking experiences (Trinidad et al., 2018), subjective dizziness and related genetic influences (Haberstick et al., 2011) and nicotinic sensitivity (Perkins et al., 2009) in adolescents and young adults. The ABCD-adapted version additionally captures respondents’ subjective experiences surrounding first use of e-cigarettes or e-hookahs, smokeless tobacco (i.e. snus or chew). The questionnaire assesses pleasant (pleasurable buzz or rush; relaxed, dizzy) and unpleasant (e.g., did you feel nausea, did you cough) experiences surrounding first-time tobacco use, rating sensations on a scale from 1 “none” to 4 “intense”.
