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Chunk #29 — RESULTS — MAOA-LPR: main effects and interaction with stressful life events at ≤ age 3.5 years; influence on hyperactivity — Girls

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Early life stress, MAOA, and gene-environment interactions predict behavioral disinhibition in children.
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MAOA-LPR genotype moderated the impact of stressful life events experienced between ages 6 months to 3 ½ years on hyperactivity in girls at 4 years (β = −0.22; 95% CI: −0.35 to −0.09; p for interaction = 0.001) and at 7 years (β = −0.18; 95% CI: −0.31 to −0.05; p for interaction = 0.009). The low activity allele was associated with increased hyperactivity in girls exposed to high stress (Figure 1).