Using a computational model to characterize the consistency of cortical projection zones into the striatum, investigators can predict striatal locations that receive specific cortical inputs. These data demonstrate that there is an exponential decay in overlap as a function of distance. 15 Thus, convergence of corticostriatal terminals from cortical areas that are separated by 5 mm is 50% in nonhuman primates. The overlap decreased to below 20% from regions separated by 30 mm. However, this distance between cortical regions can span several functional domains. For example, there is a region within the rostral, anterior striatum that receives projections from across the prefrontal cortical regions, including the vmPFC, OFC, dACC, and dorsal and lateral PFC (Figure 5c).
