Additional cross-dataset and cross-sex LDSC genetic correlation estimates were used to assess the extent of heterogeneity across PGC and iPSYCH (see Supplemental Figure S1 and Table S5). The genetic correlation between these subsamples was not significantly different from 1 [rg (SE) = 1.13 (0.22)]. Cross-dataset rg values for PGC male individuals with iPSYCH male and female individuals were also not significantly different from 1. Estimates for PGC female individuals with iPSYCH female individuals were lower (significantly different from 0 and 1), although this is likely related to the small sample size of the PGC female individuals (n = 1067 cases and n = 5178 controls).
