The observed relationship between cannabis consumption and psychosis has long been recognized [161, 231]; recent epidemiological and pharmacological studies have renewed interest in this association. But until recently, little was known about the mechanism of action of cannabinoids. Advances in understanding and knowledge about cannabinoid receptor function have prompted a fresh look at a long-recognized association between cannabinoids and psychosis. The purpose of this paper is to review the association between cannabis exposure and psychotic disorders, and offer some possible explanations underlying the association.
