71) with a peak in methylation being noted near the transcription start site of exon 1. In addition, at all points surveyed, females tended to have a higher amount of methylation with the overall average methylation ratio being significantly higher in females than in males (P < 0.0008). Surprisingly, the correlation coefficients for methylation between neighboring residues are stronger in 5′ portion of the island (0.3–0.5) then in the 3′ portion of the island (0.2) with the correlation for methylation at the opposite ends of the region surveyed being very poor (Pearson’s < 0.10) (Supplemental Table I).
