Haplotypes were constructed for four SNPs (rs10805145, rs426463, rs279827 and rs279826) in high LD (LD > 0.93) located in the proximal block (Figure 1). Because of the high LD among these SNPs haplotypes were estimated manually and without ambiguity for 288 subjects out of the 295 participants. Two major haplotypes, AAAA (54.3%) and the complementary CCGG (43.3%) were estimated without ambiguity for 288 subjects and were coded with 0, 1 and 2 if they have 0, 1 or 2 copies of the minor (risk) haplotype (CCGG), respectively.
