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Chunk #13 — Statistical Analyses — Association analyses

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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
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General Linear Models (Univariate) in SPSS was used to predict both impulsiveness and LAPS from GABRA2 SNPs. Covariates in the model were gender, age, race and DSM-IV diagnosis of AUD. To test the independent effect of SNP rs1442060, not in LD with the other SNPs, rs279827 was included as a covariate. Independent t-tests were used to compare impulsiveness and LAPS differences between subjects with and without lifetime AUD diagnosis.