BMI status, body composition and the growth process were assessed from repeated measurements of body weight, height, FFM and FM at baseline and after one-year ( Table 1 ). A nonsynonymous SNP (rs1056513; G1178S (NP_005790.2)) in INADL on chromosome 1 attained near genome-wide significance (p = 1.2E-07) for weight, and BMI, FFM, FM, trunk FM, and hip circumference (p = 8.3E-06 to 1.6E-07). SNP rs1056513 is common (MAF = 0.50) and accounted for 3% of the variance in body weight and body composition in this cohort. Weight z-score change was significantly associated with an intronic variant in COL4A1 on chromosome 13 (p = 4.7E-08) (Supporting Information Figure S1). Linear growth (height change) was associated with a variant in the 5′UTR region of TSEN34 on chromosome 19 (p = 4.5E-08).
