Genome-wide significant variants were identified for several endometabolic traits ( Table 2 ). An intronic variant in MTNR1B on chromosome 11 was strongly associated with fasting glucose (p = 3.7E-08). Intronic and 3′UTR variants in the APOA5-ZNF259 region on chromosome 11 were associated with triglycerides (p = 2.5-4.8E-08). An intronic variant in PCSK2 on chromosome 20 was associated with total antioxidants (p = 7.6E-08). Variants in the flanking 3′UTR regions of RNASE1 on chromosome 14 and ASS1P11 on chromosome 7 were associated with 24-h urinary nitrogen excretion and creatinine excretion, respectively (p = 8.2-8.4E-08). An intronic SNP in GCH1 on chromosome 14 was associated with 24-h urinary dopamine: creatinine ratio (p = 6.3E-08). A nonsynonymous SNP (rs3733402; S143T (NP_000883.2)) in KLKB1 on chromosome 4 was identified for serum free IGF-1. An intronic SNP in MPRIP on chromosome 17 was associated with serum IGFBP-3 (p = 7.2E-08). A block of twenty-three SNPs in the flanking 5′UTR region of XPA/FOXE1 (TTF-2) on chromosome 9 were highly associated with serum TSH (p = 5.5E-08 to 1.0E-09) and found to be in strong linkage disequilibrium with one another (R = 0.91−1.00).
