Genome-wide significant variants were identified for inflammation markers ( Table 3 ). Highly significant associations for a nonsynonymous SNP (rs12075; G42D (NP_002027.2) (p = 1.3E-21) and an intronic SNP (p = 3.6E-13) in DARC on chromosome 1 were identified for MCP-1. Coding variants in GREB1 on chromosome 2 (p = 6.5E-08) and DFNB31 on chromosome 9 (p = 2.0E-08) were also identified for MCP-1. A variants in the 3′UTR for CCR3 was highly associated with MCP1, as well as an intronic SNP in RASGEF1A (p = 4.6-9.6E-08). A variant in the intronic region of ABO was strongly associated with IL-6 (p = 2.0E-08).
