Symptom Inventory current depression and anxiety scores to determine whether 5-HTTLPR has similar effects on these measures and whether 5-HTTLPR modulates the effects of life events in the development of these phenotypes. We specifically tested whether age and presence of CHA affects the modifying role of 5-HTTLPR on the effect of RLE. To overcome the limitation of traditional (frequentist) statistical GxE analysis methods which have limited power to detect biological interactions [16], we calculated the Bayesian relevance of 5-HTTLPR genotypes in specified models and the ratio of risk of these phenotypes conveyed by the ss genotype after low, medium and high exposure to life stressors.
