Existing literature shows that cognitive alterations and CB1 receptor downregulation in regular cannabis users may return to normal values due to neuroadaptive phenomena occurring after periods of abstinence (Bosker et al, 2013; Hanson et al, 2010; Hirvonen et al, 2012; Schweinsburg et al, 2010). The design of our study cannot address whether the structural alterations observed are permanent or reversible. The so far unexplored evolution of the gray matter alterations across time and the possible recovery after recency of use should be addressed by further longitudinal studies.
