In our study, we provide new arguments about the effects of long-term exposure to cannabis on brain structure integrity. We were able to support all the hypotheses raised in the introduction: (i) we demonstrate that regular cannabis use is associated with reduced gray matter volume in regions rich in cannabinoid CB1 receptors that are functionally linked to motivational, emotional, and affective processing. (ii) We complete our findings by showing that the magnitude of changes in these regions correlates with the frequency of cannabis use and (iii) is modulated by the age at which consumption was initiated.
