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Chunk #4 — Introduction

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
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immune pathways. We show high genetic correlations between PTSD and related psychiatric disorders such as major depressive disorder, but present evidence that some of the identified loci are likely specific to PTSD. In addition, we construct a highly significant polygenic risk score for PTSD, which is predictive of re-experiencing symptoms (REX), a core feature of PTSD, in the independent Million Veteran Program cohort9.