We report meta-analyses of GWAS from the PGC-PTSD Freeze 2 (PGC2), comprised of an ancestrally diverse group of 206,655 participants (including 32,428 cases) from 60 different PTSD studies, ranging from clinically deeply characterized, small patient groups to large cohorts with self-reported PTSD symptoms (Supplementary Data 1). Trauma exposure included both civilian and/or military events, often with pre-existing exposure to childhood trauma, and the majority of controls were trauma-exposed. First ancestry groups were consistently defined across studies (Supplementary Fig. 1). Primary GWAS were then performed separately in the three largest ancestry groups (European (EUA), African (AFA), and Native American Ancestry (AMA)), then meta-analyzed across studies and ancestry groups. Given the previously observed differences between male and female heritability estimates in PGC-PTSD Freeze 110, we also performed sex-stratified analyses. Quantile-quantile plots showed low inflation across analyses (Supplementary Fig. 2), which was mostly accounted for by polygenic SNP effects with little indication of residual population stratification (see Supplementary Note 1 for additional information).
