These aggregate meta‐analyses, based on published data, were highly informative, but still prone to publication bias, selective reporting in primary studies, large variations in data processing and analyses across studies influencing the results, and insufficient power to undertake detailed investigations of the associations between clinical characteristics and neuroimaging findings (Boedhoe et al., 2019). To address these limitations, the OCD Brain Imaging Consortium (OBIC) was initiated in 2010; this initiative aimed to increase statistical power by pooling raw MRI data from centers around the world. Harmonization of data quality control and data processing, all performed at a single center, would limit variation across data samples to just the variation in inclusion criteria and data acquisition. Six academic OCD centers (from Asia, Europe, and South America) provided high‐quality data from 412 adult OCD patients and 368 healthy controls. Using VBM, the OBIC consortium mega‐analysis showed that compared to healthy controls, OCD patients had lower volume of the dmPFC, dACC, and bilateral insula‐operculum, largely replicating previous meta‐analytic findings (Goodkind et al., 2015; Radua et al., 2010; Radua & Mataix‐Cols, 2009), as well as
