consortium mega‐analysis showed that compared to healthy controls, OCD patients had lower volume of the dmPFC, dACC, and bilateral insula‐operculum, largely replicating previous meta‐analytic findings (Goodkind et al., 2015; Radua et al., 2010; Radua & Mataix‐Cols, 2009), as well as greater volume of the cerebellum. Group‐by‐age interaction effects illustrated that some regions (e.g., putamen) show a relative preservation of volume in OCD with increasing age while other regions (e.g., temporal regions) show a relative loss of volume in OCD with increasing age. These findings are consistent with the initial study by Pujol et al. (2004), and suggest that increased volume of the striatum/pallidum is most prominent in older OCD patients, perhaps related to disease chronicity.
