Genomic structural equation models were analyzed to answer two question: (i) do PTSD subdomains (hyperarousal, re-experiencing, and avoidance) load onto one latent factor, and (ii) does latent factor architecture and subdomain loading change in the presence of PTSD genetic and phenotypic correlates: major depressive disorder, anxiety, and neuroticism. These traits – all part of the internalizing spectrum22,39 – are highly phenotypically and genetically correlated with PTSD.
