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Chunk #8 — Methods — — Study procedures and sample

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Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers.
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Data were collected in 2007–2009 from 1,349 adult household residents, as described elsewhere (Hasin et al., 2002). This sample was designed to investigate environmental and genetic influences on alcohol-related traits. Because drinking among Israeli women is limited (Hasin et al., 1998; Shmulewitz et al., 2012; Spivak et al., 2007), males were oversampled. Interviewers received structured training and administered face-to-face computer-assisted interviews after obtaining written informed consent as approved by relevant IRBs (Shmulewitz et al., 2012). The overall response rate was 68.9%. Quality control included field observation, reviews of recorded interviews, and telephone verification of responses. The present analysis included 1,143 ever-drinkers (ever drank alcohol, lifetime) who provided information about childhood experiences and were genotyped for ADH1B-rs1229984. Of these, 78.3% (N=895) were male; 23.9% (N=273) were immigrants from the Former Soviet Union (FSU); 13.1% (N=177) met criteria for DSM-IV AUD; and the mean age was 41.3 (SD=12.9).