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Chunk #14 — Results — Application to Summary Statistics From 25 Phenotypes

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An atlas of genetic correlations across human diseases and traits.
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We used cross-trait LD Score regression to estimate genetic correlations among 24 phenotypes (URLs, Methods). Genetic correlation estimates for all 276 pairwise combinations of the 24 traits are shown in Figure 2. For clarity of presentation, the 24 phenotypes were restricted to contain only one phenotype from each cluster of closely related phenotypes (Methods). Genetic correlations among the educational, anthropometric, smoking, and insulin-related phenotypes that were excluded from Figure 2 are shown Supplementary Figures 1, 2, 3 and 4, respectively. A full table of 1176 genetic correlations among 49 traits is provided in Supplementary Table 4. References and sample sizes are shown in Supplementary Table 3.