Chunk #13 — Materials and Methods — Family based association test

Source

Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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Haplotype associations were tested by the program HBAT in the FBAT package (Laird et al 2000). We adopted the global haplotype association test with Monte Carlo simulation, i.e., repeated random sampling, to compute an exact global p-value for multi-haplotype based association (http://www.biostat.harvard.edu/~fbat/default.html).