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Chunk #11 — RESULTS — Distribution of CNVs Across Disorders — Strict Criteria for CNV Assignment

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Distribution of disease-associated copy number variants across distinct disorders of cognitive development.
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average number of genes per CNV for each disorder was as follows: ID—49 genes; ASD—28 genes; schizophrenia—32 genes; and epilepsy—47 genes. Notably, ID CNVs were significantly larger than ASD CNVs (p=.009) (Figure 2). Also CNVs were categorized as either deletion or duplication. As shown in Figure 2A, ID demonstrated a majority of deletions, 67% as compared 33% duplications, yet by contrast schizophrenia exhibited 57% deletions and 43% duplications. However, there were no statistically significant differences between deletions and duplications across DSM disorders.