The subgroup condition by control group categories showed efficacy of disulfiram when compared to (1) the no disulfiram condition (eight studies), (2) naltrexone (nine studies), and (3) acamprosate (three studies). These three studies had a combined total of 403 subjects. Other evidence outside of this meta-analysis in favor of disulfiram compared to acamprosate comes from retrospective data from 2002–2007 with 353 alcoholic patients [60]. In the present study, disulfiram was also superior to topiramate and showed no difference with GHB in these single trial categories, thus providing less useful information as only one study was available. The global picture of this subgroup analysis suggests a favorable image of the efficacy of disulfiram when compared with two of the most evidence based drugs for alcohol dependence.
