Second, despite being a quantitative index of alcohol consumption, maximum number of drinks consumed in a single 24-hour period (MAXD) was less effectively predicted by the alcohol consumption PRS (R2 ≤ 0.31%). MAXD is genetically correlated with problem drinking (Agrawal et al., 2009; Grant et al., 2009) and correlates well with quantitative indices of tolerance (Kendler et al., 2012; Schuckit et al., 2008). The lower prediction might be related to MAXD being potentially influenced by a single episode of heavy drinking and thus, not indicative of either typical or problem drinking. Likewise, total scores on the subjective ratings of ethanol (SRE-T) was not predicted by alcohol consumption PRS. SRE-T is an index of alcohol sensitivity and has primarily been studied as a predisposing factor for and predictor of later problem drinking (Schuckit & Smith, 2013). Individuals with higher SRE-T scores demonstrate lower level of response to alcohol, potentially via dampening of neural and physiological pathways in response to alcohol (Schuckit, 2018; Schuckit et al., 2008). There are currently no published GWAS of SRE-T, although a meta-analysis of a related but
