demonstrate lower level of response to alcohol, potentially via dampening of neural and physiological pathways in response to alcohol (Schuckit, 2018; Schuckit et al., 2008). There are currently no published GWAS of SRE-T, although a meta-analysis of a related but etiologically distinct trait representing subjective ratings of ethanol during the first five times that alcohol was consumed (SRE-5) did not find loci previously associated with alcohol consumption or dependence to be related to it (Edwards et al., 2018). Thus, even though SRE is heritable (Kalu et al., 2012) and related to alcohol consumption, its genetic underpinnings may be quite different from those related to alcohol intake.
