We have previously reported the results of the most extreme hits from Phase 1 of our GWA study with independent replication(4), identifying 15q25, 5p and 6p as disease loci for lung cancer. Here, we report comprehensive findings from our GWA study. In Phase 1 we genotyped 561,466 tagging single nucleotide polymorphisms (SNPs) in 1,978 lung cancer cases, comparing genotype frequencies with 1,438 controls. In Phase 2 we genotyped 33,060 selected SNPs in 2,484 lung cancer cases and 3,036 controls. This analysis in conjunction with a meta-analysis of two other GWA studies(2, 4) provides insight into the genetic architecture of inherited susceptibility to lung cancer.
