number of antidepressants and antipsychotics, such as clozapine and risperidone (80), underscoring their potential role in the neurophysiology of psychiatric disorders. The risk SNP at HTR7 for alcohol dependence had significant eQTL signal in in human lymphoblastoid cell lines and is predicted to highly significantly alter the RNA secondary structure. Interestingly, an antisense LncRNA is located in the promoter of HTR7, 450bp from the transcription start site (TSS). This is a LncRNA bidirectional to HTR7. A Bidirectional LncRNA transcript usually exhibits a similar expression pattern to its protein-coding counterpart (here, HTR7). It can open chromatin to promote the expression of HTR7 (81). A SNP within this LncRNA was associated with alcohol dependence.
