The HTR7 gene on Chr10 encodes a G-protein-coupled serotonergic receptor. Serotonin (5-HT), one of the most widely used neurotransmitters in the brain, binds to this receptor and produces physiological effects that has been implicated in the etiology of numerous psychiatric diseases, including schizophrenia, depression, obsessive-compulsive, social phobia, and eating disorders (75–77). HTR7 is distributed in discrete areas of the brain, such as the limbic system and thalamocortical regions, overlapping the areas of neuroelectrical activity of θ EROs, which suggests a possible role of HTR7 in pathophysiology of psychiatric disorders. The development of 5-HT7 antagonists (78) and the generation of a Htr7 knockout mouse (79) have revealed a role for the receptor in the control of circadian rhythms and sleep, as well as in modulating hippocampal neuronal functions such as learning and memory. 5-HT7 receptors have a high affinity for a number of antidepressants and antipsychotics, such as clozapine and risperidone (80), underscoring their potential role in the neurophysiology of psychiatric disorders. The risk SNP at HTR7 for alcohol dependence had significant eQTL signal in in human lymphoblastoid cell lines and
