Chunk #24 — Discussion — Selective effects of recent life events related to financial difficulties in interaction with the 5-HTTLPR genotype in the development of depressive symptoms
that may have divergent consequences. Identifying which environments and effects are most prominent in such genetic interactions would help to identify those who are at greatest risk.45 In spite of this, apart from a previous study in adults reporting that the 5-HTTLPR-rs25531 mini-haplotype moderates the relationship between depression and separation from partner within the preceding year in a synergistic manner,46 the effect of specific types of life events has been little studied; therefore, we have a limited understanding of what neurochemical and neuroanatomical mechanisms may modulate any differential effect.
