Chunk #23 — Discussion — Selective effects of recent life events related to financial difficulties in interaction with the 5-HTTLPR genotype in the development of depressive symptoms
Our findings are not only novel but could also help to explain why contradictory results emerged in previous studies not stratifying for different types of recent life events. Furthermore, our findings are similar to those reported in case of childhood adversities where it was also demonstrated that not all types of early childhood maltreatment, but most prominently childhood sexual and to a lesser extent physical abuse is modulated by 5-HTTLPR.17, 31, 32, 44 These results suggest that different types of life events are possibly modulated by different neural mechanisms involving different neuroanatomical structures and neurochemical components, and different genes. It is increasingly suggested that the environmental context related to stressful and adverse events should be specified more accurately and more multidimensionally because stress and adverse events are very broad terms. They encompass a wide variety of environmental effects and contexts that may have divergent consequences. Identifying which environments and effects are most prominent in such genetic interactions would help to identify those who are at greatest risk.45 In spite of this, apart from a previous study in adults reporting that
