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Chunk #7 — Materials and Methods — SNP selection

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Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine.
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SNPs were selected using a MAF range of 0.5–5% in either the EA or AA population. Missense and nonsense SNPs located within the main OPRM1 isoform (MOR-1) were prioritized for genotyping. This led to the identification of 4 SNPs for genotyping in our addicted populations: rs62638690 and rs17174794 in EA’s and rs1799971 and rs17174801 in AA’s.