Chunk #21 — 3. RESULTS — 3.1. The G (Asp) allele of rs1799971 shows a modest protective effect on general substance dependence

Source

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

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To reduce potential heterogeneity among the general dependence controls, we meta-analyzed the 10 datasets that had all five substance-specific dependence diagnoses and at least 5 cases and 5 controls. For these 10 datasets (3947 cases and 2348 controls), the summary odds ratio was 0.87 (p-value = 0.01), very similar to the discovery result based on 20 studies.