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Chunk #20 — 3. RESULTS — 3.1. The G (Asp) allele of rs1799971 shows a modest protective effect on general substance dependence

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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
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Leave-one-out test of robustness yielded odds ratio estimates ranging from 0.88 to 0.92, with none of the 20 iterations showing significant heterogeneity. This tight range of ORs centered on the overall odds ratio indicates that our finding was not driven by a single dataset. Only a few of the individual iterations showed significant association (e.g. 4 of 20 when using α′ =9.76×10−3 as the significance threshold), likely due to the reduced sample size.