The identified regions cover the anterior part of the body of the corpus callosum, which connects premotor and motor regions of both hemispheres and the genu of the corpus callosum connects large portions of the prefrontal cortices [67, 68]. Another cluster of WM structure changes was located in the cingulum bundle which interconnects frontal, parietal, and medial temporal brain regions as well as subcortical nuclei to the cingulate gyrus [69]. The posterior limb of the internal capsule comprises fibers that connect visual, auditory, somatosensory, and motor regions [70, 71]. Regarding the functional consequences, even subtle alterations in areas of the corpus callosum and cingulate bundle can lead to numerous functional impairments, as they represent important WM structures with interhemispheric and intrahemispheric pathways [69, 72], respectively. WM alterations within these structures could explain to some extent the decline in motor, affective, perceptive, and cognitive functions related to AUD [73]. For example, AUD-related alterations in callosal fibers are associated with changes in executive function [45] and decision-making deficits [60]. In particular, reduced integrity of the genu of the corpus callosum could be
