Chunk #38 — Methods — Glial cell-mediated glutamatergic dysfunction in co-occurring SUDs and depression

Source

Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity?

Embedded

yes

Text

The first and second hypotheses may pertain to some dually diagnosed subjects (Crum et al. 2013), but these disorders rarely develop in isolation and almost never arise linearly. Therefore, the third cumulative/synergistic hypothesis appears most consistent with the clinical phenomenology of comorbidity.