Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity?

paper Cited Public

Authors: Niciu, Mark J; Henter, Ioline D; Sanacora, Gerard; Zarate, Carlos A
Year: 2014
Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
PMID: 24024876
DOI: 10.3109/15622975.2013.829585
PMCID: PMC4180366

#	Section	Preview
0	Introduction	Substance use disorders (SUDs) frequently co-occur with other psychiatric illnesses. Conversely,…
1	Methods	Peer-reviewed PubMed/Medline articles published through December 2012 were identified using the…
2	Methods — Astrocytes — Alcohol	Historically, astrocyte activation has been defined by glial fibrillary acidic protein (GFAP)…
3	Methods — Astrocytes — Alcohol	Preclinical studies have demonstrated that pre-frontal cortex (PFC) GFAP-immunoreactive cell density…
4	Methods — Astrocytes — Alcohol	Next, alcohol induces glutamatergic neurotransmission abnormalities in astrocytes. Under…
5	Methods — Astrocytes — Alcohol	hyperpolarization of rat hippocampal neurons (Mulholland et al. 2009). In addition, the…
6	Methods — Astrocytes — Alcohol	Taken together, the evidence from preclinical alcoholism models as well as clinical studies suggests…
7	Methods — Astrocytes — Illicit drugs	Drugs of abuse also adversely affect astrocytes, providing potential pathophysiological mechanisms…
8	Methods — Astrocytes — Illicit drugs	On a behavioural level, the infusion of astrocyte-conditioned media into the rodent NAcc incites…
9	Methods — Astrocytes — Illicit drugs	Similar to the effects of methamphetamines, chronic morphine treatment increases GFAP expression in…
10	Methods — Astrocytes — Illicit drugs	In addition to their critical role in neurotransmitter dynamics, activated astrocytes also secrete…
11	Methods — Astrocytes — Depression	Astrocytes have also been implicated in the aetiopathogenesis of preclinical models of despair and…
12	Methods — Astrocytes — Depression	Data are mixed regarding diagnostic specificity, e.g., decreased GFAP expression in the amygdala of…
13	Methods — Astrocytes — Depression	In reverse translational studies, rats subjected to 15 days of chronic unpredictable stress (CUS)…
14	Methods — Astrocytes — Depression	In addition to morphological deficits, stress-induction paradigms also affect neurotrophin secretion…
15	Methods — Astrocytes — Depression	Astrocytes secrete many neurotrophins in response to antidepressants; amitriptyline increases basic…
16	Methods — Astrocytes — Depression	Astrocyte perturbations have also been studied in suicide. Astrocytic hypertrophy with…
17	Methods — Astrocytes — Depression	Preclinical/mechanistic investigations have been conducted into the aetiopathophysiology of impaired…
18	Methods — Astrocytes — Depression	Adding support for a central role for glutamate, glutamate transporter downregulation has been…
19	Methods — Microglia — Alcohol	There is a burgeoning literature on microglia in alcohol use disorders (see Table II). In adolescent…

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In this knowledge base

Title	Year	PMID
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	2018	29897633

External

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In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [<sup>11</sup>C]ABP688 and [<sup>18</sup>F]FPEB.	DeLorenzo C et al.	—	2017	→
Astrocytes: a central element in neurological diseases.	Pekny M et al.	—	2016	→
Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core.	Scofield MD et al.	—	2016	→
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Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects.	Peng L et al.	—	2014	→