The glutamate homeostasis hypothesis of addiction.
paper
Cited
Public
Unavailable
- Authors
- Kalivas, Peter W
- Year
- 2009
- Journal
- Nature reviews. Neuroscience
- PMID
- 19571793
- DOI
- 10.1038/nrn2515
Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is important for guiding adaptive behaviour. The hierarchy of corticostriatal information processing that normally permits the prefrontal cortex to regulate reinforcement-seeking behaviours is impaired by chronic drug use. A failure of the prefrontal cortex to control drug-seeking behaviours can be linked to an enduring imbalance between synaptic and non-synaptic glutamate, termed glutamate homeostasis. The imbalance in glutamate homeostasis engenders changes in neuroplasticity that impair communication between the prefrontal cortex and the nucleus accumbens. Some of these pathological changes are amenable to new glutamate- and neuroplasticity-based pharmacotherapies for treating addiction.
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| Effects of NMDA receptor antagonists on behavioral economic indices of cocaine self-administration. | Horchar MJ et al. | — | 2022 | → |
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| Enhanced psychostimulant response, but not social avoidance, depends on GluA1 AMPA receptors in VTA dopamine neurons following intermittent social defeat stress in rats. | Rudolph ML et al. | — | 2022 | → |
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| Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. | Avalos MP et al. | — | 2022 | → |
| Insomnia as a moderator of alcohol use and blackout: Potential role in acute physiological consequences. | Miller MB et al. | — | 2022 | → |
| IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. | Li S et al. | — | 2022 | → |
| Ketamine and Other Glutamate Receptor Modulating Agents for Treatment-Resistant Depression: A Systematic Review of Randomized Controlled Trials. | Shamabadi A et al. | — | 2022 | → |
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| Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. | Avalos MP et al. | — | 2022 | → |
| N-acetylcysteine aggravates seizures while improving depressive-like and cognitive impairment comorbidities in the WAG/Rij rat model of absence epilepsy. | Tallarico M et al. | — | 2022 | → |
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| Novelty-induced locomotor behavior predicts heroin addiction vulnerability in male, but not female, rats. | Kuhn BN et al. | — | 2022 | → |
| Nuclear factor kappa B signaling within the rat nucleus accumbens core sex-dependently regulates cue-induced cocaine seeking and matrix metalloproteinase-9 expression. | Namba MD et al. | — | 2022 | → |
| P2X7 Receptor Augments LPS-Induced Nitrosative Stress by Regulating Nrf2 and GSH Levels in the Mouse Hippocampus. | Lee DS et al. | — | 2022 | → |
| Plasticity in astrocyte subpopulations regulates heroin relapse. | Kruyer A et al. | — | 2022 | → |
| Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. | Morgan C et al. | — | 2022 | → |
| Prenatal Opioid Exposure Impairs Endocannabinoid and Glutamate Transmission in the Dorsal Striatum. | Grecco GG et al. | — | 2022 | → |
| Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics. | de Bartolomeis A et al. | — | 2022 | → |
| Recent Advances in the Modulation of Pain by the Metabotropic Glutamate Receptors. | Mazzitelli M et al. | — | 2022 | → |
| Regulation of glutamate homeostasis in the nucleus accumbens by astrocytic CB1 receptors and its role in cocaine-motivated behaviors. | Zhang LY et al. | — | 2022 | → |
| Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. | Prisciandaro JJ et al. | — | 2022 | → |
| Systematic review: Wearable remote monitoring to detect nonalcohol/nonnicotine-related substance use disorder symptoms. | Oesterle TS et al. | — | 2022 | → |
| The effect of self-administered methamphetamine on GABAergic interneuron populations and functional connectivity of the nucleus accumbens and prefrontal cortex. | Robinson KJ et al. | — | 2022 | → |
| The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. | Marcos A et al. | — | 2022 | → |
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| The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders. | Bradlow RCJ et al. | — | 2022 | → |
| The Role of SLC7A11 in Cancer: Friend or Foe? | Li S et al. | — | 2022 | → |
| Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine. | Yamasaki T et al. | — | 2022 | → |
| White Matter Tracts Associated With Deep Brain Stimulation Targets in Major Depressive Disorder: A Systematic Review. | Yu Q et al. | — | 2022 | → |
| Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity. | Leyrer-Jackson JM et al. | — | 2021 | → |
| A common limiter circuit for opioid choice and relapse identified in a rodent addiction model. | Heinsbroek JA et al. | — | 2021 | → |
| AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses. | Wang YQ et al. | — | 2021 | → |
| Animal Models of Anxiety and Depression: Incorporating the Underlying Mechanisms of Sex Differences in Macroglia Biology. | Wegener AJ et al. | — | 2021 | → |
| Application of Three Ecological Assessment Tools in Examining Chromatographic Methods for the Green Analysis of a Mixture of Dopamine, Serotonin, Glutamate and GABA: A Comparative Study. | Almalki AH et al. | — | 2021 | → |
| Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation. | Israel Y et al. | — | 2021 | → |
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| Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration. | Faccidomo S et al. | — | 2021 | → |
| Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders? | Angarita GA et al. | — | 2021 | → |
| CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context. | Guzman AS et al. | — | 2021 | → |
| Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders. | Hade AC et al. | — | 2021 | → |
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| Cocaine experience induces functional adaptations in astrocytes: Implications for synaptic plasticity in the nucleus accumbens shell. | O'Donovan B et al. | — | 2021 | → |
| Cocaine Induces Sex-Associated Changes in Lipid Profiles of Brain Extracellular Vesicles. | Landfield Q et al. | — | 2021 | → |
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| Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight. | Angoa-Pérez M et al. | — | 2021 | → |
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| Insulin restores the neurochemical effects of nicotine in the mesolimbic pathway of diabetic rats. | Cruz B et al. | — | 2021 | → |
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| Lifetime heavy drinking years predict alcohol use disorder severity over and above current alcohol use. | Nieto SJ et al. | — | 2021 | → |
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| Mechanistic insights into the efficacy of memantine in treating certain drug addictions. | Montemitro C et al. | — | 2021 | → |
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| MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling. | Huang G et al. | — | 2021 | → |
| Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward. | Reeves KC et al. | — | 2021 | → |
| N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals. | Woodcock EA et al. | — | 2021 | → |
| Nature of glutamate alterations in substance dependence: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies. | Chen T et al. | — | 2021 | → |
| Negative allosteric modulation of metabotropic glutamate receptor 5 attenuates alcohol self-administration in baboons. | Salling MC et al. | — | 2021 | → |
| Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior. | Oliveira TPD et al. | — | 2021 | → |
| Neurochemical substrates linked to impulsive and compulsive phenotypes in addiction: A preclinical perspective. | Jones JA et al. | — | 2021 | → |
| Neurometabolic alterations in the nucleus accumbens of smokers assessed with <sup>1</sup> H magnetic resonance spectroscopy: The role of glutamate and neuroinflammation. | Steinegger CA et al. | — | 2021 | → |
| Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus. | Rimmele TS et al. | — | 2021 | → |
| Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens. | Thompson BL et al. | — | 2021 | → |
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| Oxytocin and Addiction: Potential Glutamatergic Mechanisms. | Sundar M et al. | — | 2021 | → |
| Partial connectomes of labeled dopaminergic circuits reveal non-synaptic communication and axonal remodeling after exposure to cocaine. | Wildenberg G et al. | — | 2021 | → |
| Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders. | Onaolapo AY et al. | — | 2021 | → |
| Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior. | Almalki AH et al. | — | 2021 | → |
| Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection. | Bischoff-Grethe A et al. | — | 2021 | → |
| Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap? | Hersey M et al. | — | 2021 | → |
| Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction. | Ersche KD et al. | — | 2021 | → |
| Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. | Zhang LY et al. | — | 2021 | → |
| SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells. | Wang J et al. | — | 2021 | → |
| Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2. | Boender AJ et al. | — | 2021 | → |
| Susceptibility to extinction and reinstatement of ethanol-induced conditioned place preference is related to differences in astrocyte cystine-glutamate antiporter content. | Amaral VCS et al. | — | 2021 | → |
| Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse. | Peng S et al. | — | 2021 | → |
| Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling. | Wang M et al. | — | 2021 | → |
| The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - A randomized proof of concept study. | Schulte MHJ et al. | — | 2021 | → |
| The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress. | Raghu G et al. | — | 2021 | → |
| The Role of CaMKII and ERK Signaling in Addiction. | Jia W et al. | — | 2021 | → |
| The role of HINT1 protein in morphine addiction: An animal model-based study. | Liu P et al. | — | 2021 | → |
| Unbiased Metabolomics Links Fatty Acid Pathways to Psychiatric Symptoms in People Living with HIV. | Meeder E et al. | — | 2021 | → |
| VALTOCO<sup>®</sup> (Diazepam Nasal Spray) for the Acute Treatment of Intermittent Stereotypic Episodes of Frequent Seizure Activity. | Cornett EM et al. | — | 2021 | → |
| Viral vector-mediated gene therapy for opioid use disorders. | Wang T et al. | — | 2021 | → |
| Administration of <i>N</i>-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats. | Quintanilla ME et al. | — | 2020 | → |
| Adolescent ethanol exposure and differential rearing environment affect taste reactivity to ethanol in rats. | Wukitsch TJ et al. | — | 2020 | → |
| Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. | Sanna F et al. | — | 2020 | → |
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| Calcineurin Promotes Neuroplastic Changes in the Amygdala Associated with Weakened Cocaine-Cue Memories. | Rich MT et al. | — | 2020 | → |
| Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. | Suárez J et al. | — | 2020 | → |
| Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D<sub>2</sub> and GluA1 AMPA receptor expression in rats. | Jiang WN et al. | — | 2020 | → |
| Deconstructing the neurobiology of cannabis use disorder. | Ferland JN et al. | — | 2020 | → |
| Decreased Neuronal Excitability in Medial Prefrontal Cortex during Morphine Withdrawal is associated with enhanced SK channel activity and upregulation of small GTPase Rac1. | Qu L et al. | — | 2020 | → |
| Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking. | Guercio LA et al. | — | 2020 | → |
| Deletion of P2X7 Receptor Decreases Basal Glutathione Level by Changing Glutamate-Glutamine Cycle and Neutral Amino Acid Transporters. | Park H et al. | — | 2020 | → |
| Effects of chronic ethanol consumption on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats. | Alhaddad H et al. | — | 2020 | → |
| Effects of Cocaine Exposure on Astrocytic Glutamate Transporters and Relapse-Like Ethanol-Drinking Behavior in Male Alcohol-Preferring Rats. | Hammad AM et al. | — | 2020 | → |
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| Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. | Bilbao A et al. | — | 2020 | → |
| Environmental enrichment and a selective metabotropic glutamate receptor<sub>2/3</sub> (mGluR<sub>2/3</sub>) agonist suppress amphetamine self-administration: Characterizing baseline differences. | Garcia EJ et al. | — | 2020 | → |
| Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect. | Powell GL et al. | — | 2020 | → |
| Ethanol metabolism: The good, the bad, and the ugly. | Wilson DF et al. | — | 2020 | → |
| Evidence That Cannabis Exposure, Abuse, and Dependence Are Related to Glutamate Metabolism and Glial Function in the Anterior Cingulate Cortex: A <sup>1</sup>H-Magnetic Resonance Spectroscopy Study. | Watts JJ et al. | — | 2020 | → |
| Exposure to Commercial Cigarette Smoke Produces Psychomotor Sensitization Via Hyperstimulation of Glutamate Response in the Dorsal Striatum. | Ryu IS et al. | — | 2020 | → |
| Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning. | Hervig ME et al. | — | 2020 | → |
| Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs. | Barr JL et al. | — | 2020 | → |
| Hypersensitivity to amphetamine's psychomotor and reinforcing effects in serotonin transporter knockout rats: Glutamate in the nucleus accumbens. | Caffino L et al. | — | 2020 | → |
| Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect. | McConnell PA et al. | — | 2020 | → |
| Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning. | Andreska T et al. | — | 2020 | → |
| Insights into the Neurobiology of Craving in Opioid Use Disorder. | Lueptow LM et al. | — | 2020 | → |
| Lasting reduction of nicotine-seeking behavior by chronic N-acetylcysteine during experimental cue-exposure therapy. | Moro F et al. | — | 2020 | → |
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| Markers of glutamate and GABA neurotransmission in the prefrontal cortex of schizophrenia subjects: Disease effects differ across anatomical levels of resolution. | Dienel SJ et al. | — | 2020 | → |
| Metabotropic glutamate receptor 5 in bulimia nervosa. | Mihov Y et al. | — | 2020 | → |
| N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy. | Notartomaso S et al. | — | 2020 | → |
| N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats. | Ward P et al. | — | 2020 | → |
| N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking. | Goenaga J et al. | — | 2020 | → |
| Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens. | Nam HW et al. | — | 2020 | → |
| Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go-Nogo and Flanker tasks. | Lesage E et al. | — | 2020 | → |
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| Opioid use disorder. | Strang J et al. | — | 2020 | → |
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| Potential of Glial Cell Modulators in the Management of Substance Use Disorders. | Jones JD | — | 2020 | → |
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| Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission. | Wright WJ et al. | — | 2020 | → |
| Recovery of Decreased Metabotropic Glutamate Receptor 5 Availability in Abstinent Alcohol-Dependent Patients. | Ceccarini J et al. | — | 2020 | → |
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| Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice. | Brown CN et al. | — | 2020 | → |
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| Anatomic Review of the Ventral Capsule/Ventral Striatum and the Nucleus Accumbens to Guide Target Selection for Deep Brain Stimulation for Obsessive-Compulsive Disorder. | Park YS et al. | — | 2019 | → |
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| Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. | Liu M et al. | — | 2019 | → |
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| Tropisetron Facilitates Footshock Suppression of Compulsive Cocaine Seeking. | Zhou YQ et al. | — | 2019 | → |
| VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths. | Vrettou M et al. | — | 2019 | → |
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| Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry. | Walker DM et al. | — | 2018 | → |
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| Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction. | Cross AJ et al. | — | 2018 | → |
| Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus. | Wang J et al. | — | 2018 | → |
| Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction. | Neuhofer D et al. | — | 2018 | → |
| Methamphetamine promotes habitual action and alters the density of striatal glutamate receptor and vesicular proteins in dorsal striatum. | Furlong TM et al. | — | 2018 | → |
| mGluR2/3 mediates short-term control of nicotine-seeking by acute systemic N-acetylcysteine. | Moro F et al. | — | 2018 | → |
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| Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist. | Hajasova Z et al. | — | 2018 | → |
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| Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. | Yang HJ et al. | — | 2017 | → |
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| Exposure to PM<sub>2.5</sub> causes genetic changes in fetal rat cerebral cortex and hippocampus. | Chao MW et al. | — | 2017 | → |
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| Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells. | Lv C et al. | — | 2017 | → |
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| mGluR5 activation in the nucleus accumbens is not essential for sexual behavior or cross-sensitization of amphetamine responses by sexual experience. | Pitchers KK et al. | — | 2016 | → |
| Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. | Lewitus GM et al. | — | 2016 | → |
| MMP-9 in translation: from molecule to brain physiology, pathology, and therapy. | Vafadari B et al. | — | 2016 | → |
| Modulation of Chronic Pain by Metabotropic Glutamate Receptors. | Chiechio S | — | 2016 | → |
| Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. | Enrico P et al. | — | 2016 | → |
| N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement. | Jastrzębska J et al. | — | 2016 | → |
| N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice. | Bowers MS et al. | — | 2016 | → |
| N-acetylcysteine Facilitates Self-Imposed Abstinence After Escalation of Cocaine Intake. | Ducret E et al. | — | 2016 | → |
| N-acetylcysteine treatment blocks the development of ethanol-induced behavioural sensitization and related ΔFosB alterations. | Morais-Silva G et al. | — | 2016 | → |
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| Neuroimaging markers of glutamatergic and GABAergic systems in drug addiction: Relationships to resting-state functional connectivity. | Moeller SJ et al. | — | 2016 | → |
| Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3). | Storey GP et al. | — | 2016 | → |
| Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. | Russell SE et al. | — | 2016 | → |
| One month of cocaine abstinence potentiates rapid dopamine signaling in the nucleus accumbens core. | Cameron CM et al. | — | 2016 | → |
| Perisynaptic astroglial processes: dynamic processors of neuronal information. | Ghézali G et al. | — | 2016 | → |
| Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation. | Rich MT et al. | — | 2016 | → |
| Prefrontal Cortex to Accumbens Projections in Sleep Regulation of Reward. | Liu Z et al. | — | 2016 | → |
| Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors. | Pitts EG et al. | — | 2016 | → |
| Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. | McGlinchey EM et al. | — | 2016 | → |
| Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction? | Johnson KA et al. | — | 2016 | → |
| Presynaptic, release-regulating mGlu2 -preferring and mGlu3 -preferring autoreceptors in CNS: pharmacological profiles and functional roles in demyelinating disease. | Di Prisco S et al. | — | 2016 | → |
| Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine. | You ZB et al. | — | 2016 | → |
| Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice. | Barker JM et al. | — | 2016 | → |
| Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement. | Hearing MC et al. | — | 2016 | → |
| Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens. | Khibnik LA et al. | — | 2016 | → |
| The dose makes the poison: from glutamate-mediated neurogenesis to neuronal atrophy and depression. | Rubio-Casillas A et al. | — | 2016 | → |
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| The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats. | Augier E et al. | — | 2016 | → |
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| Time to connect: bringing social context into addiction neuroscience. | Heilig M et al. | — | 2016 | → |
| TiO2 nanoparticle-induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice. | Ze X et al. | — | 2016 | → |
| Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats. | Rao KN et al. | — | 2016 | → |
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| Astrocytes in the medial preoptic area modulate ejaculation latency in an experience-dependent fashion. | Will RG et al. | — | 2015 | → |
| Brain Rewarding Stimulation Reduces Extracellular Glutamate Through Glial Modulation in Medial Prefrontal Cortex of Rats. | Murakami G et al. | — | 2015 | → |
| Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. | Leão RM et al. | — | 2015 | → |
| Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats. | Odeon MM et al. | — | 2015 | → |
| Co-administration of ethanol and nicotine: the enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats. | Deehan GA et al. | — | 2015 | → |
| Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI. | Perrine SA et al. | — | 2015 | → |
| Cocaine self-administration causes signaling deficits in corticostriatal circuitry that are reversed by BDNF in early withdrawal. | McGinty JF et al. | — | 2015 | → |
| Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. | Rubio FJ et al. | — | 2015 | → |
| Deficits in behavioral sensitization and dopaminergic responses to methamphetamine in adenylyl cyclase 1/8-deficient mice. | Bosse KE et al. | — | 2015 | → |
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| Differential roles of medial prefrontal subregions in the regulation of drug seeking. | Moorman DE et al. | — | 2015 | → |
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| Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease. | Takahashi K et al. | — | 2015 | → |
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| Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. | Reissner KJ et al. | — | 2015 | → |
| Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. | Scofield MD et al. | — | 2015 | → |
| HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol. | Bertrand SJ et al. | — | 2015 | → |
| Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing N-methyl-D-aspartate receptors in the nucleus accumbens. | McGuier NS et al. | — | 2015 | → |
| Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior. | Kamii H et al. | — | 2015 | → |
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| Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse? | Johnson KA et al. | — | 2015 | → |
| Mindfulness, Mechanisms and Meaning: Perspectives from the Cognitive Neuroscience of Addiction. | McConnell PA et al. | — | 2015 | → |
| Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. | Yarosh HL et al. | — | 2015 | → |
| N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. | Oliver G et al. | — | 2015 | → |
| N-acetylcysteine prevents behavioral and biochemical changes induced by alcohol cessation in rats. | Schneider R et al. | — | 2015 | → |
| On the role of A₂A and D₂ receptors in control of cocaine and food-seeking behaviors in rats. | Wydra K et al. | — | 2015 | → |
| Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth. | Hill SY et al. | — | 2015 | → |
| Role of ionotropic glutamate receptors in delay and probability discounting in the rat. | Yates JR et al. | — | 2015 | → |
| Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior. | Harasta AE et al. | — | 2015 | → |
| Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats. | Eagle AL et al. | — | 2015 | → |
| Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. | Nasca C et al. | — | 2015 | → |
| Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure. | DePoy LM et al. | — | 2015 | → |
| The dark side of emotion: the addiction perspective. | Koob GF | — | 2015 | → |
| The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background. | Miguéns M et al. | — | 2015 | → |
| The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study. | Froeliger B et al. | — | 2015 | → |
| The ins and outs of the striatum: role in drug addiction. | Yager LM et al. | — | 2015 | → |
| The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies. | Terbeck S et al. | — | 2015 | → |
| The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction. | Smith AC et al. | — | 2015 | → |
| The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors. | Root DH et al. | — | 2015 | → |
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| Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction. | Cruz FC et al. | — | 2015 | → |
| Withdrawal from cocaine self-administration and yoked cocaine delivery dysregulates glutamatergic mGlu5 and NMDA receptors in the rat brain. | Pomierny-Chamiolo L et al. | — | 2015 | → |
| Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. | Kreple CJ et al. | — | 2014 | → |
| Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. | Chen YW et al. | — | 2014 | → |
| Adaptations in AMPA receptor transmission in the nucleus accumbens contributing to incubation of cocaine craving. | Loweth JA et al. | — | 2014 | → |
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| Adenosine and glutamate in neuroglial interaction: implications for circadian disorders and alcoholism. | Ruby CL et al. | — | 2014 | → |
| A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra. | Rae CD | — | 2014 | → |
| Amantadine and cognitive flexibility: decision making in Parkinson's patients with severe pathological gambling and other impulse control disorders. | Cera N et al. | — | 2014 | → |
| Amygdala and bed nucleus of the stria terminalis circuitry: Implications for addiction-related behaviors. | Stamatakis AM et al. | — | 2014 | → |
| Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. | Scofield MD et al. | — | 2014 | → |
| Behavioral characterization of system xc- mutant mice. | McCullagh EA et al. | — | 2014 | → |
| Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections. | Ma YY et al. | — | 2014 | → |
| Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine. | Jeanblanc J et al. | — | 2014 | → |
| Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism. | Reissner KJ et al. | — | 2014 | → |
| Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens. | MacAskill AF et al. | — | 2014 | → |
| Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. | Parikh V et al. | — | 2014 | → |
| Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse. | Cahill E et al. | — | 2014 | → |
| Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. | Wakabayashi KT et al. | — | 2014 | → |
| Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. | Xie P et al. | — | 2014 | → |
| Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development. | Neisewander JL et al. | — | 2014 | → |
| Dopamine dysregulation syndrome in Parkinson's disease: from clinical and neuropsychological characterisation to management and long-term outcome. | Cilia R et al. | — | 2014 | → |
| Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. | Kramar CP et al. | — | 2014 | → |
| Drug abuse and the simplest neurotransmitter. | Kreple CJ et al. | — | 2014 | → |
| Drug withdrawal conceptualized as a stressor. | Chartoff EH et al. | — | 2014 | → |
| Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats. | Parsegian A et al. | — | 2014 | → |
| Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice. | Frederick NM et al. | — | 2014 | → |
| Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. | Corbit LH et al. | — | 2014 | → |
| Emerging role of CaMKII in neuropsychiatric disease. | Robison AJ | — | 2014 | → |
| Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates. | Hernandez G et al. | — | 2014 | → |
| Escalation of cocaine intake and incubation of cocaine seeking are correlated with dissociable neuronal processes in different accumbens subregions. | Guillem K et al. | — | 2014 | → |
| Essential role of poly(ADP-ribosyl)ation in cocaine action. | Scobie KN et al. | — | 2014 | → |
| Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. | Enoch MA et al. | — | 2014 | → |
| Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice. | Edamura M et al. | — | 2014 | → |
| Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior. | Caprioli D et al. | — | 2014 | → |
| Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. | Mistry CJ et al. | — | 2014 | → |
| Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity? | Niciu MJ et al. | — | 2014 | → |
| Glial modulators as potential treatments of psychostimulant abuse. | Beardsley PM et al. | — | 2014 | → |
| Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. | van Huijstee AN et al. | — | 2014 | → |
| Habitual alcohol seeking: modeling the transition from casual drinking to addiction. | Barker JM et al. | — | 2014 | → |
| Implication of NMDA receptors in behavioural sensitization to psychostimulants: a short review. | Landa L et al. | — | 2014 | → |
| Impulsive and compulsive behaviors in Parkinson's disease. | Averbeck BB et al. | — | 2014 | → |
| Impulsive and compulsive behaviors in Parkinson's disease. | Zhang G et al. | — | 2014 | → |
| Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. | Griffin WC et al. | — | 2014 | → |
| Influence of depressive symptoms on dopaminergic treatment of Parkinson's disease. | Hanganu A et al. | — | 2014 | → |
| Inhibition of vesicular glutamate transporters contributes to attenuate methamphetamine-induced conditioned place preference in rats. | He Z et al. | — | 2014 | → |
| It's MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system. | Chartoff EH et al. | — | 2014 | → |
| "Killing Two Birds with One Stone": Alcohol Use Reduction Interventions with Potential Efficacy in Enhancing Self-Control. | Leeman RF et al. | — | 2014 | → |
| Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats. | Wang J et al. | — | 2014 | → |
| Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study. | Milella MS et al. | — | 2014 | → |
| Metabotropic glutamate receptor 3 is associated with heroin dependence but not depression or schizophrenia in a Chinese population. | Jia W et al. | — | 2014 | → |
| Metabotropic glutamatergic receptors and their ligands in drug addiction. | Pomierny-Chamioło L et al. | — | 2014 | → |
| Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. | Mahler SV et al. | — | 2014 | → |
| Nucleus accumbens neuronal activity correlates to the animal's behavioral response to acute and chronic methylphenidate. | Claussen CM et al. | — | 2014 | → |
| Optogenetic dissection of medial prefrontal cortex circuitry. | Riga D et al. | — | 2014 | → |
| Pathophysiology of glia in perinatal white matter injury. | Back SA et al. | — | 2014 | → |
| Potential role of N-acetylcysteine in the management of substance use disorders. | McClure EA et al. | — | 2014 | → |
| Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface. | Ruocco LA et al. | — | 2014 | → |
| Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens. | Salamone A et al. | — | 2014 | → |
| Sensitization of ethanol-induced place preference as a result of up-regulation of type 1 inositol 1,4,5-trisphosphate receptors in mouse nucleus accumbens. | Kurokawa K et al. | — | 2014 | → |
| Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans. | Hulka LM et al. | — | 2014 | → |
| Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving. | Loweth JA et al. | — | 2014 | → |
| Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse. | Shen HW et al. | — | 2014 | → |
| Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism. | Bosse KE et al. | — | 2014 | → |
| Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives. | Pettorruso M et al. | — | 2014 | → |
| Thalamic glutamate decreases with cigarette smoking. | O'Neill J et al. | — | 2014 | → |
| The development and maintenance of drug addiction. | Wise RA et al. | — | 2014 | → |
| The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats. | Arndt DL et al. | — | 2014 | → |
| The effects of subanesthetic ketamine infusions on motivation to quit and cue-induced craving in cocaine-dependent research volunteers. | Dakwar E et al. | — | 2014 | → |
| The mGlu5 receptor regulates extinction of cocaine-driven behaviours. | Bird MK et al. | — | 2014 | → |
| Topiramate for cocaine dependence during methadone maintenance treatment: a randomized controlled trial. | Umbricht A et al. | — | 2014 | → |
| Treatment of Gambling Disorders. | Yip SW et al. | — | 2014 | → |
| Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. | Herrero-Turrión MJ et al. | — | 2014 | → |
| α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse. | Spencer S et al. | — | 2014 | → |
| Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure. | Wang W et al. | — | 2013 | → |
| Addiction: craving: a core issue. | Welberg L | — | 2013 | → |
| Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. | Ding ZM et al. | — | 2013 | → |
| AMPA receptor endocytosis in the amygdala is involved in the disrupted reconsolidation of Methamphetamine-associated contextual memory. | Yu YJ et al. | — | 2013 | → |
| Amphetamine-induced sensitization has little effect on multiple learning paradigms and fails to rescue mice with a striatal learning defect. | Eldred KC et al. | — | 2013 | → |
| A multistep general theory of transition to addiction. | Piazza PV et al. | — | 2013 | → |
| Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors. | Lodge D et al. | — | 2013 | → |
| Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptor. | Sławińska A et al. | — | 2013 | → |
| Are AMPA receptor positive allosteric modulators potential pharmacotherapeutics for addiction? | Watterson LR et al. | — | 2013 | → |
| A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior. | Plaza-Zabala A et al. | — | 2013 | → |
| Astrocytes are a neural target of morphine action via glucocorticoid receptor-dependent signaling. | Slezak M et al. | — | 2013 | → |
| Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration. | Kufahl PR et al. | — | 2013 | → |
| Bidirectional modulation of cocaine expectancy by phasic glutamate fluctuations in the nucleus accumbens. | Suto N et al. | — | 2013 | → |
| Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation. | Post RM et al. | — | 2013 | → |
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| Chemical gradients within brain extracellular space measured using low flow push-pull perfusion sampling in vivo. | Slaney TR et al. | — | 2013 | → |
| Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system. | Durazzo TC et al. | — | 2013 | → |
| Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus. | Kurosawa R et al. | — | 2013 | → |
| Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). | Smith RJ et al. | — | 2013 | → |
| Common and distinct neural targets of treatment: changing brain function in substance addiction. | Konova AB et al. | — | 2013 | → |
| Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration. | Kiraly DD et al. | — | 2013 | → |
| Conventional concepts and new perspectives for understanding the addictive properties of inhalants. | Duncan JR et al. | — | 2013 | → |
| Cortical control of VTA function and influence on nicotine reward. | Wu J et al. | — | 2013 | → |
| Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice. | Jiang Q et al. | — | 2013 | → |
| Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. | Theberge FR et al. | — | 2013 | → |
| Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome. | Eipper-Mains JE et al. | — | 2013 | → |
| Effects of metabotropic glutamate receptor ligands on male sexual behavior in rats. | Li X et al. | — | 2013 | → |
| Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement. | Cannady R et al. | — | 2013 | → |
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| Exogenous BDNF facilitates strategy set-shifting by modulating glutamate dynamics in the dorsal striatum. | D'Amore DE et al. | — | 2013 | → |
| Group III metabotropic glutamate receptors and drug addiction. | Mao L et al. | — | 2013 | → |
| High-frequency stimulation of nucleus accumbens changes in dopaminergic reward circuit. | Yan N et al. | — | 2013 | → |
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| Identification of neuronal loci involved with displays of affective aggression in NC900 mice. | Nehrenberg DL et al. | — | 2013 | → |
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| Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. | Bardo MT et al. | — | 2013 | → |
| Inhibition of glycine transporter-1 reduces cue-induced nicotine-seeking, but does not promote extinction of conditioned nicotine cue responding in the rat. | Cervo L et al. | — | 2013 | → |
| Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. | Vélez-Hernández ME et al. | — | 2013 | → |
| Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter. | Ende G et al. | — | 2013 | → |
| Low- and high-cocaine locomotor responding rats differ in reinstatement of cocaine seeking and striatal mGluR5 protein expression. | Simmons DL et al. | — | 2013 | → |
| Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography. | Akkus F et al. | — | 2013 | → |
| Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. | Lee BR et al. | — | 2013 | → |
| Molecular mechanisms of cannabinoid addiction. | Fratta W et al. | — | 2013 | → |
| N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. | Ramirez-Niño AM et al. | — | 2013 | → |
| Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. | Pitchers KK et al. | — | 2013 | → |
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| Nucleus accumbens deep brain stimulation results in insula and prefrontal activation: a large animal FMRI study. | Knight EJ et al. | — | 2013 | → |
| Opiate dependence induces network state shifts in the limbic system. | Dejean C et al. | — | 2013 | → |
| Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. | Stefanik MT et al. | — | 2013 | → |
| Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. | Chandra R et al. | — | 2013 | → |
| Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats. | Calu DJ et al. | — | 2013 | → |
| Oxidative stress biomarkers in some rat brain structures and peripheral organs underwent cocaine. | Pomierny-Chamioło L et al. | — | 2013 | → |
| Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. | Nunez YO et al. | — | 2013 | → |
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| Psychostimulant-induced neuroadaptations in nucleus accumbens AMPA receptor transmission. | Pierce RC et al. | — | 2013 | → |
| Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. | Gipson CD et al. | — | 2013 | → |
| Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. | Meinhardt MW et al. | — | 2013 | → |
| Role of mGluR5 neurotransmission in reinstated cocaine-seeking. | Wang X et al. | — | 2013 | → |
| Role of nucleus accumbens glutamatergic plasticity in drug addiction. | Quintero GC | — | 2013 | → |
| Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates. | Murnane KS et al. | — | 2013 | → |
| Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. | Lee MR et al. | — | 2013 | → |
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| The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. | Lewerenz J et al. | — | 2013 | → |
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| The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. | Chesworth R et al. | — | 2013 | → |
| The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior. | Cannella N et al. | — | 2013 | → |
| The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans. | Taylor SB et al. | — | 2013 | → |
| Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization. | Gancarz-Kausch AM et al. | — | 2013 | → |
| Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche. | Loweth JA et al. | — | 2013 | → |
| Ventral tegmental area GABA neurons and opiate motivation. | Ting-A-Kee R et al. | — | 2013 | → |
| Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal. | Liu Y et al. | — | 2012 | → |
| Acute alcohol intoxication impairs top-down regulation of Stroop incongruity as revealed by blood oxygen level-dependent functional magnetic resonance imaging. | Marinkovic K et al. | — | 2012 | → |
| Addiction circuitry in the human brain. | Volkow ND et al. | — | 2012 | → |
| Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. | Nam HW et al. | — | 2012 | → |
| Amantadine in the treatment of pathological gambling: a case report. | Pettorruso M et al. | — | 2012 | → |
| An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction. | Dayas CV et al. | — | 2012 | → |
| Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm. | Abulseoud OA et al. | — | 2012 | → |
| Chronic modafinil effects on drug-seeking following methamphetamine self-administration in rats. | Reichel CM et al. | — | 2012 | → |
| Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes. | Marchi M et al. | — | 2012 | → |
| Compulsive features in behavioural addictions: the case of pathological gambling. | el-Guebaly N et al. | — | 2012 | → |
| Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. | Duncan JR | — | 2012 | → |
| Dehydroepiandrosterone sulphate: action and mechanism in the brain. | Dong Y et al. | — | 2012 | → |
| Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury. | Hinzman JM et al. | — | 2012 | → |
| Distinct neurochemical adaptations within the nucleus accumbens produced by a history of self-administered vs non-contingently administered intravenous methamphetamine. | Lominac KD et al. | — | 2012 | → |
| Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats. | Gabriele A et al. | — | 2012 | → |
| Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. | Marty VN et al. | — | 2012 | → |
| Environmental enrichment reduces attribution of incentive salience to a food-associated stimulus. | Beckmann JS et al. | — | 2012 | → |
| Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity. | Ary AW et al. | — | 2012 | → |
| Food and drug reward: overlapping circuits in human obesity and addiction. | Volkow ND et al. | — | 2012 | → |
| Getting good or getting well? | Dye LR | — | 2012 | → |
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| Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. | Eipper-Mains JE et al. | — | 2012 | → |
| Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes. | Mon A et al. | — | 2012 | → |
| Glutamate mechanisms underlying opiate memories. | Peters J et al. | — | 2012 | → |
| Glutamate transporter 1: target for the treatment of alcohol dependence. | Rao PS et al. | — | 2012 | → |
| Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. | Higuchi S et al. | — | 2012 | → |
| Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats. | Zhang D et al. | — | 2012 | → |
| Integrating synaptic plasticity and striatal circuit function in addiction. | Grueter BA et al. | — | 2012 | → |
| Intravenous gestational nicotine exposure results in increased motivation for sucrose reward in adult rat offspring. | Lacy RT et al. | — | 2012 | → |
| Lighting up the brain's reward circuitry. | Lobo MK | — | 2012 | → |
| Maternal separation and proclivity for ethanol intake: a potential role of the endocannabinoid system in rats. | Romano-López A et al. | — | 2012 | → |
| Mechanisms of psychostimulant-induced structural plasticity. | Golden SA et al. | — | 2012 | → |
| Medial prefrontal cortex neuronal activation and synaptic alterations after stress-induced reinstatement of palatable food seeking: a study using c-fos-GFP transgenic female rats. | Cifani C et al. | — | 2012 | → |
| Metabotropic glutamate receptors and the control of chronic pain. | Chiechio S et al. | — | 2012 | → |
| Metabotropic glutamate receptors for new treatments in schizophrenia. | Herman EJ et al. | — | 2012 | → |
| mGlu5 Receptor Functional Interactions and Addiction. | Brown RM et al. | — | 2012 | → |
| N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors. | Bernabucci M et al. | — | 2012 | → |
| Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens. | Pitchers KK et al. | — | 2012 | → |
| Neurocircuitry for modeling drug effects. | Noori HR et al. | — | 2012 | → |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | — | 2012 | → |
| Neuroplasticity in addiction: cellular and transcriptional perspectives. | Madsen HB et al. | — | 2012 | → |
| Nicotine self-administered directly into the VTA by rats is weakly reinforcing but has strong reinforcement enhancing properties. | Farquhar MJ et al. | — | 2012 | → |
| NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory. | Zhou SJ et al. | — | 2012 | → |
| Nucleus accumbens neuronal activity in freely behaving rats is modulated following acute and chronic methylphenidate administration. | Chong SL et al. | — | 2012 | → |
| Optogenetic modulation of neural circuits that underlie reward seeking. | Stuber GD et al. | — | 2012 | → |
| Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence. | Sidique S et al. | — | 2012 | → |
| Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. | Haile CN et al. | — | 2012 | → |
| Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration. | Kufahl PR et al. | — | 2012 | → |
| Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. | Le Merrer J et al. | — | 2012 | → |
| Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. | Dietz DM et al. | — | 2012 | → |
| Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area. | Lu L et al. | — | 2012 | → |
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| Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity. | Leeman RF et al. | — | 2012 | → |
| Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei. | Esparza MA et al. | — | 2012 | → |
| Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. | Dumitriu D et al. | — | 2012 | → |
| System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. | Bridges RJ et al. | — | 2012 | → |
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| The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. | Kupchik YM et al. | — | 2012 | → |
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| Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. | Bridges R et al. | — | 2012 | → |
| Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. | Sanacora G et al. | — | 2012 | → |
| Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. | Hermann D et al. | — | 2012 | → |
| Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines. | Ferrario CR et al. | — | 2012 | → |
| Addiction and brain reward and antireward pathways. | Gardner EL | — | 2011 | → |
| Addiction: beyond dopamine reward circuitry. | Volkow ND et al. | — | 2011 | → |
| AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis. | Reissner KJ et al. | — | 2011 | → |
| Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving. | Ferrario CR et al. | — | 2011 | → |
| An eight component decision-making model for problem gambling: a systems approach to stimulate integrative research. | Nussbaum D et al. | — | 2011 | → |
| A Role for Sigma Receptors in Stimulant Self Administration and Addiction. | Katz JL et al. | — | 2011 | → |
| Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking. | Tanchuck MA et al. | — | 2011 | → |
| Binge toluene exposure alters glutamate, glutamine and GABA in the adolescent rat brain as measured by proton magnetic resonance spectroscopy. | Perrine SA et al. | — | 2011 | → |
| Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. | Sondheimer I et al. | — | 2011 | → |
| Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. | Reichel CM et al. | — | 2011 | → |
| Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex. | Lee CT et al. | — | 2011 | → |
| Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. | Uys JD et al. | — | 2011 | → |
| Cocaine-induced homeostatic regulation and dysregulation of nucleus accumbens neurons. | Huang YH et al. | — | 2011 | → |
| Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal. | Dobi A et al. | — | 2011 | → |
| Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry. | Chen YI et al. | — | 2011 | → |
| Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. | Dhanya RP et al. | — | 2011 | → |
| Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine. | Veeneman MM et al. | — | 2011 | → |
| Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals. | Brown AL et al. | — | 2011 | → |
| Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. | Goldstein RZ et al. | — | 2011 | → |
| Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the rat nucleus accumbens. | Ferrario CR et al. | — | 2011 | → |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | — | 2011 | → |
| Environmental novelty causes stress-like adaptations at nucleus accumbens synapses: implications for studying addiction-related plasticity. | Rothwell PE et al. | — | 2011 | → |
| Exercise as a potential treatment for drug abuse: evidence from preclinical studies. | Smith MA et al. | — | 2011 | → |
| FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons. | Guez-Barber D et al. | — | 2011 | → |
| Gestational IV nicotine produces elevated brain-derived neurotrophic factor in the mesocorticolimbic dopamine system of adolescent rat offspring. | Harrod SB et al. | — | 2011 | → |
| Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment. | Pittenger C et al. | — | 2011 | → |
| Glutamatergic neuroplasticity in cocaine addiction. | Uys JD et al. | — | 2011 | → |
| Glutamatergic plasticity in medial prefrontal cortex and ventral tegmental area following extended-access cocaine self-administration. | Ghasemzadeh MB et al. | — | 2011 | → |
| Glutathione is a physiologic reservoir of neuronal glutamate. | Koga M et al. | — | 2011 | → |
| Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. | Shen H et al. | — | 2011 | → |
| Identification of kalirin-7 as a potential post-synaptic density signaling hub. | Kiraly DD et al. | — | 2011 | → |
| Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challenge. | Miyake N et al. | — | 2011 | → |
| Implication of the purinergic system in alcohol use disorders. | Asatryan L et al. | — | 2011 | → |
| Integrins modulate relapse to cocaine-seeking. | Wiggins A et al. | — | 2011 | → |
| Investigating Methamphetamine Craving Using the Extinction-Reinstatement Model in the Rat. | Kufahl PR et al. | — | 2011 | → |
| Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. | Kiraly DD et al. | — | 2011 | → |
| Lesions and reversible inactivation of the dorsolateral caudate-putamen impair cocaine-primed reinstatement to cocaine-seeking in rats. | Gabriele A et al. | — | 2011 | → |
| Management of punding in Parkinson's disease: an open-label prospective study. | Fasano A et al. | — | 2011 | → |
| MDMA ("ecstasy") abuse as an example of dopamine neuroplasticity. | Schenk S | — | 2011 | → |
| Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust. | Richard JM et al. | — | 2011 | → |
| Metabotropic glutamate receptors: from the workbench to the bedside. | Nicoletti F et al. | — | 2011 | → |
| Molecular diffusion model of neurotransmitter homeostasis around synapses supporting gradients. | Mohan A et al. | — | 2011 | → |
| Muscarinic acetylcholine receptors in the nucleus accumbens core and shell contribute to cocaine priming-induced reinstatement of drug seeking. | Yee J et al. | — | 2011 | → |
| Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. | Miwa JM et al. | — | 2011 | → |
| Neuroanatomical and neurochemical substrates of timing. | Coull JT et al. | — | 2011 | → |
| Neurobiology of the incubation of drug craving. | Pickens CL et al. | — | 2011 | → |
| New medications for drug addiction hiding in glutamatergic neuroplasticity. | Kalivas PW et al. | — | 2011 | → |
| Nucleus accumbens invulnerability to methamphetamine neurotoxicity. | Kuhn DM et al. | — | 2011 | → |
| Opiate versus psychostimulant addiction: the differences do matter. | Badiani A et al. | — | 2011 | → |
| Post-translational modification biology of glutamate receptors and drug addiction. | Mao LM et al. | — | 2011 | → |
| Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions. | Perry JL et al. | — | 2011 | → |
| Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. | Lammel S et al. | — | 2011 | → |
| Quantitative analysis of AMPA receptor subunit composition in addiction-related brain regions. | Reimers JM et al. | — | 2011 | → |
| Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures. | Nakagawa T et al. | — | 2011 | → |
| Retracted: The pre-synaptic metabotropic glutamate receptor 7 "mGluR7" is a critical modulator of ethanol sensitivity in mice. | Bahi A | — | 2011 | → |
| Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. | Moussawi K et al. | — | 2011 | → |
| Role of the serotonergic system in alcohol dependence: from animal models to clinics. | Sari Y et al. | — | 2011 | → |
| Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. | Wissman AM et al. | — | 2011 | → |
| Synaptic adaptations in the nucleus accumbens caused by experiences linked to relapse. | Rothwell PE et al. | — | 2011 | → |
| The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. | Lobo MK et al. | — | 2011 | → |
| Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine. | Richards CI et al. | — | 2011 | → |
| Transcriptional and epigenetic mechanisms of addiction. | Robison AJ et al. | — | 2011 | → |
| Translating glutamate: from pathophysiology to treatment. | Javitt DC et al. | — | 2011 | → |
| What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? | Cumming P et al. | — | 2011 | → |
| β-Lactam antibiotic produces a sustained reduction in extracellular glutamate in the nucleus accumbens of rats. | Rasmussen BA et al. | — | 2011 | → |
| Acamprosate. | Kennedy WK et al. | — | 2010 | → |
| A central role for the periphery in the rapid action of cocaine on brain neurons: focus on "Rapid EEG desynchronization and EMG activation induced by intravenous cocaine in freely moving rats: a peripheral, nondopamine neural triggering". | Rebec GV | — | 2010 | → |
| Alcohol and the prefrontal cortex. | Abernathy K et al. | — | 2010 | → |
| Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. | Chen J et al. | — | 2010 | → |
| AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine. | Wolf ME et al. | — | 2010 | → |
| AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats. | Carr KD et al. | — | 2010 | → |
| AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future. | Bowers MS et al. | — | 2010 | → |
| An essential role for adenosine signaling in alcohol abuse. | Ruby CL et al. | — | 2010 | → |
| A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons. | Zhang Y et al. | — | 2010 | → |
| An integrated genome research network for studying the genetics of alcohol addiction. | Spanagel R et al. | — | 2010 | → |
| Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. | Coyle JT et al. | — | 2010 | → |
| Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction. | Cantin L et al. | — | 2010 | → |
| Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. | Garcia BG et al. | — | 2010 | → |
| Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat. | Faure A et al. | — | 2010 | → |
| Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase. | Schroeder JP et al. | — | 2010 | → |
| Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration. | Suto N et al. | — | 2010 | → |
| Extracellular matrix plasticity and GABAergic inhibition of prefrontal cortex pyramidal cells facilitates relapse to heroin seeking. | Van den Oever MC et al. | — | 2010 | → |
| Glutamatergic targets for enhancing extinction learning in drug addiction. | Cleva RM et al. | — | 2010 | → |
| Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. | Moussawi K et al. | — | 2010 | → |
| Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: a computational approach. | Piray P et al. | — | 2010 | → |
| Inhibition of actin polymerization prevents cocaine-induced changes in spine morphology in the nucleus accumbens. | Toda S et al. | — | 2010 | → |
| Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. | Yao L et al. | — | 2010 | → |
| [Involvement of dysfunction of glia-neuron network in chronic pain and drug addiction]. | Nakagawa T | — | 2010 | → |
| Modafinil: an anti-relapse medication. | Tahsili-Fahadan P et al. | — | 2010 | → |
| Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse. | Reichel CM et al. | — | 2010 | → |
| New horizons for therapeutics in drug and alcohol abuse. | Jupp B et al. | — | 2010 | → |
| Pathological gambling in Parkinson disease is reduced by amantadine. | Thomas A et al. | — | 2010 | → |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | — | 2010 | → |
| Pharmacotherapeutic approach to the treatment of addiction: persistent challenges. | Zahm DS | — | 2010 | → |
| Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens. | Grueter BA et al. | — | 2010 | → |
| Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex. | Hascup ER et al. | — | 2010 | → |
| Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1. | Nam HW et al. | — | 2010 | → |
| Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaine. | Wolf ME | — | 2010 | → |
| Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. | Fonseca F et al. | — | 2010 | → |
| Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization. | Ceglia I et al. | — | 2010 | → |
| Stress-related receptor targets for cocaine addiction. | Self DW | — | 2010 | → |
| Synapse pathology in psychiatric and neurologic disease. | van Spronsen M et al. | — | 2010 | → |
| Synaptic plasticity, a symphony in GEF. | Kiraly DD et al. | — | 2010 | → |
| The Bermuda Triangle of cocaine-induced neuroadaptations. | Wolf ME | — | 2010 | → |
| The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. | Jin X et al. | — | 2010 | → |
| The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice. | O'Connor EC et al. | — | 2010 | → |
| Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. | Chiechio S et al. | — | 2010 | → |
| Transition to addiction is associated with a persistent impairment in synaptic plasticity. | Kasanetz F et al. | — | 2010 | → |
| Using glutamate homeostasis as a target for treating addictive disorders. | Reissner KJ et al. | — | 2010 | → |
| The promiscuous mGlu5 receptor--a range of partners for therapeutic possibilities? | Bird MK et al. | — | 2009 | → |