The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.
paper
Cited
Public
Unavailable
- Authors
- Spanagel, Rainer; Pendyala, Gurudutt; Abarca, Carolina; Zghoul, Tarek; Sanchis-Segura, Carles; Magnone, Maria Chiara; Lascorz, Jesús; Depner, Martin; Holzberg, David; Soyka, Michael; Schreiber, Stefan; Matsuda, Fumihiko; Lathrop, Mark; Schumann, Gunter; Albrecht, Urs
- Year
- 2005
- Journal
- Nature medicine
- PMID
- 15608650
- DOI
- 10.1038/nm1163
Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2(Brdm1) mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transporter Eaat1 is observed in these animals, leading to reduced uptake of glutamate by astrocytes. As a consequence, glutamate levels increase in the extracellular space of Per2(Brdm1) mutant mouse brains. This is accompanied by increased alcohol intake in these animals. In humans, variations of the PER2 gene are associated with regulation of alcohol consumption. Acamprosate, a drug used to prevent craving and relapse in alcoholic patients is thought to act by dampening a hyper-glutamatergic state. This drug reduced augmented glutamate levels and normalized increased alcohol consumption in Per2(Brdm1) mutant mice. Collectively, these data establish glutamate as a link between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology. | Bailey SM | — | 2026 | → |
| A fused deep learning approach to transform drug repositioning. | Li K et al. | — | 2025 | → |
| Beyond vision: effects of light on the circadian clock and mood-related behaviours. | Stewart D et al. | — | 2025 | → |
| Broflanilide induces zebrafish neurobehavioral defects by interfering with synaptic homeostasis. | Wang K et al. | — | 2025 | → |
| Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications. | Ren Q et al. | — | 2025 | → |
| DAILY - A personalized circadian <i>Zeitgeber</i> therapy as an adjunctive treatment for alcohol use disorder patients: results of a pilot trial. | Springer N et al. | — | 2025 | → |
| Glia: the cellular glue that binds circadian rhythms and sleep. | Carvalhas-Almeida C et al. | — | 2025 | → |
| Irregular light schedules disrupt daily rhythms and dysregulate genes involved in neuroplasticity, motivation, and stress responses. | Berbegal-Sáez P et al. | — | 2025 | → |
| Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice. | Korkmaz H et al. | — | 2025 | → |
| Low dose baclofen and standard dose acamprosate had comparable changes in brain glutamate, brain Gamma amino butyric acid (GABA) and craving among patients with alcohol dependence syndrome: A 1H-MRS based open label randomized study. | Kesan A et al. | — | 2025 | → |
| Molecular Imaging Studies of Alcohol Use Disorder. | Bach P et al. | — | 2025 | → |
| Stat3 Silencing Affects Circadian Clock Gene Expression and Lipopolysaccharide Response in the Suprachiasmatic Nucleus, Cortex, and Glioblastoma Cell Cultures. | Filipovská E et al. | — | 2025 | → |
| A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD). | Samanta S et al. | — | 2024 | → |
| Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders. | Das U et al. | — | 2024 | → |
| Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors. | Allen O et al. | — | 2024 | → |
| Differential Serum Levels of CACNA1C, Circadian Rhythm and Stress Response Molecules in Subjects with Bipolar Disorder: Associations with Genetic and Clinical Factors | Allen O et al. | — | 2024 | — |
| Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review. | Sharma P et al. | — | 2024 | → |
| Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats. | Meyer C et al. | — | 2024 | → |
| Sex- and Substance-Specific Associations of Circadian-Related Genes with Addiction in the UK Biobank Cohort Implicate Neuroplasticity Pathways. | Khan A et al. | — | 2024 | → |
| Suppression of neuropathic pain in the circadian clock-deficient <i>Per2<sup>m/m</sup></i> mice involves up-regulation of endocannabinoid system. | Yamakawa W et al. | — | 2024 | → |
| Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection. | Xu S et al. | — | 2024 | → |
| Alcohol sensitivity and tolerance encoding in sleep regulatory circadian neurons in Drosophila. | Lange AP et al. | — | 2023 | → |
| Aryl Hydrocarbon Receptor in Glia Cells: A Plausible Glutamatergic Neurotransmission Orchestrator. | Silva-Parra J et al. | — | 2023 | → |
| A Three-Way Interaction of Sex, PER2 <i>rs56013859</i> Polymorphism, and Family Maltreatment in Depressive Symptoms in Adolescents. | Torres Soler C et al. | — | 2023 | → |
| Circadian Clocks in the Regulation of Neurotransmitter Systems. | Kiehn JT et al. | — | 2023 | → |
| Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly. | Hastings MH et al. | — | 2023 | → |
| Circadian rhythms and glial cells of the central nervous system. | Brécier A et al. | — | 2023 | → |
| Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study Circadian Rhythmicity in Psychiatric Disorders. | Palm D et al. | — | 2023 | → |
| Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking. | Nalberczak-Skóra M et al. | — | 2023 | → |
| Korean Red Ginseng extract attenuates alcohol-induced addictive responses and cognitive impairments by alleviating neuroinflammation. | Kim HJ et al. | — | 2023 | → |
| Stress-related neuropeptide systems as targets for treatment of alcohol addiction: A clinical perspective. | Heilig M | — | 2023 | → |
| The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer's disease: The role of circadian rhythm disturbances. | Amidfar M et al. | — | 2023 | → |
| Understanding neuron-glia crosstalk and biological clocks in insomnia. | Carvalhas-Almeida C et al. | — | 2023 | → |
| Alcohol solution strength preference predicts compulsive-like drinking behavior in rats. | Foo JC et al. | — | 2022 | → |
| Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior. | Becker-Krail DD et al. | — | 2022 | → |
| Circadian Control of Glial Cell Homeodynamics. | Rojo D et al. | — | 2022 | → |
| Circadian gene × environment perturbations influence alcohol drinking in Cryptochrome-deficient mice. | Hühne A et al. | — | 2022 | → |
| Differentially Expressed Genes in <i>Period 2</i>-Overexpressing Mice Striatum May Underlie Their Lower Sensitivity to Methamphetamine Addiction-Like Behavior. | Sayson LV et al. | — | 2022 | → |
| FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. | Bowen MT et al. | — | 2022 | → |
| <i>Rev-erb</i>α Knockout Reduces Ethanol Consumption and Preference in Male and Female Mice. | Al-Sabagh Y et al. | — | 2022 | → |
| Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans. | Han ND et al. | — | 2022 | → |
| MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy. | Mohammadi AH et al. | — | 2022 | → |
| Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology. | McCarthy MJ et al. | — | 2022 | → |
| Poor Sleep in Community-Dwelling Polysubstance Users: Association With Khat Dependence, Metacognition, and Socio-Demographic Factors. | Manzar MD et al. | — | 2022 | → |
| The Circadian Molecular Machinery in CNS Cells: A Fine Tuner of Neuronal and Glial Activity With Space/Time Resolution. | Fagiani F et al. | — | 2022 | → |
| The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats. | Meyer C et al. | — | 2022 | → |
| The Impact of Sex, Circadian Disruption, and the Clock<sup>Δ19/Δ19</sup> Genotype on Alcohol Drinking in Mice. | Rizk AA et al. | — | 2022 | → |
| The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets. | Zhang Y et al. | — | 2022 | → |
| Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice. | Sharma R et al. | — | 2021 | → |
| Astrocyte Circadian Timekeeping in Brain Health and Neurodegeneration. | Brancaccio M et al. | — | 2021 | → |
| Astrocyte Clocks and Glucose Homeostasis. | Barca-Mayo O et al. | — | 2021 | → |
| Astroglia in the Vulnerability and Maintenance of Alcohol Use Disorders. | Miguel-Hidalgo JJ | — | 2021 | → |
| Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish. | Mech AM et al. | — | 2021 | → |
| Blockade of alcohol excessive and "relapse" drinking in male mice by pharmacological cryptochrome (CRY) activation. | Zhou Y et al. | — | 2021 | → |
| Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner. | de Zavalia N et al. | — | 2021 | → |
| Calcium Carbonate Attenuates Withdrawal and Reduces Craving: A Randomized Controlled Trial in Alcohol-Dependent Patients. | Schuster R et al. | — | 2021 | → |
| Circadian rhythms and substance use disorders: A bidirectional relationship. | Tamura EK et al. | — | 2021 | → |
| Comparison of effects in sustained and diel-cycling hypoxia on hypoxia tolerance, histology, physiology and expression of clock genes in high latitude fish Phoxinus lagowskii. | Wang J et al. | — | 2021 | → |
| Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice. | Martini T et al. | — | 2021 | → |
| Depression-like behavior is associated with lower Per2 mRNA expression in the lateral habenula of rats. | Li Y et al. | — | 2021 | → |
| Dual Effect of <i>PER2</i> C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment. | Mazzeo S et al. | — | 2021 | → |
| Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction. | Saad L et al. | — | 2021 | → |
| Gene Expression Profiling in the Striatum of <i>Per2</i> KO Mice Exhibiting More Vulnerable Responses against Methamphetamine. | Kim M et al. | — | 2021 | → |
| Genetic Basis of Dual Diagnosis: A Review of Genome-Wide Association Studies (GWAS) Focusing on Patients with Mood or Anxiety Disorders and Co-Occurring Alcohol-Use Disorders. | Stoychev K et al. | — | 2021 | → |
| Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study. | Biernacka JM et al. | — | 2021 | → |
| Genomic perspectives on the circadian clock hypothesis of psychiatric disorders. | von Schantz M et al. | — | 2021 | → |
| How Psychoactive Drugs and the Circadian Clock Are Enlightening One Another. | Engmann O | — | 2021 | → |
| Light affects behavioral despair involving the clock gene Period 1. | Olejniczak I et al. | — | 2021 | → |
| PER2 mediates CREB-dependent light induction of the clock gene Per1. | Brenna A et al. | — | 2021 | → |
| Pharmacotherapies for the Treatment of Alcohol Use Disorders During Pregnancy: Time to Reconsider? | Kelty E et al. | — | 2021 | → |
| Repeated evolution of circadian clock dysregulation in cavefish populations. | Mack KL et al. | — | 2021 | → |
| Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function. | Siemann JK et al. | — | 2021 | → |
| rs1344706 polymorphism of zinc finger protein 804a (ZNF804a) gene related to the integrity of white matter fiber bundle in schizophrenics. | Zhou J et al. | — | 2021 | → |
| Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy. | Sandhu MRS et al. | — | 2020 | → |
| Circadian modulation of motivation in mice. | Acosta J et al. | — | 2020 | → |
| Clarifying the role of sleep in depression: A narrative review. | Pandi-Perumal SR et al. | — | 2020 | → |
| DAILY-A Personalized Circadian <i>Zeitgeber</i> Therapy as an Adjunctive Treatment for Alcohol Use Disorder Patients: Study Protocol for a Randomized Controlled Trial. | Hühne A et al. | — | 2020 | → |
| Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. | Fructuoso M et al. | — | 2020 | → |
| Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents. | Behn C et al. | — | 2020 | → |
| Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation. | Ahrens AM et al. | — | 2020 | → |
| Ruminal epithelial cell proliferation and short-chain fatty acid transporters in vitro are associated with abundance of period circadian regulator 2 (PER2). | Gao J et al. | — | 2020 | → |
| Sleep and circadian risk factors for alcohol problems: a brief overview and proposed mechanisms. | Hasler BP et al. | — | 2020 | → |
| Sleep disorders and disrupted sleep in addiction, withdrawal and abstinence with focus on alcohol and opioids. | Reid-Varley WB et al. | — | 2020 | → |
| Transcriptional control of synaptic components by the clock machinery. | Hannou L et al. | — | 2020 | → |
| Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms. | Jia YF et al. | — | 2020 | → |
| Astrocytes and Circadian Rhythms: An Emerging Astrocyte-Neuron Synergy in the Timekeeping System. | Barca Mayo O et al. | — | 2019 | → |
| Brain Imaging-Guided Analysis Reveals DNA Methylation Profiles Correlated with Insular Surface Area and Alcohol Use Disorder. | Zhao Y et al. | — | 2019 | → |
| Circadian blueprint of metabolic pathways in the brain. | Greco CM et al. | — | 2019 | → |
| Circadian disruption favors alcohol consumption and differential ΔFosB accumulation in Corticolimbic structures. | Reséndiz-Flores M et al. | — | 2019 | → |
| Circadian entrainment by food and drugs of abuse. | Gillman AG et al. | — | 2019 | → |
| Developing neuroscience-based treatments for alcohol addiction: A matter of choice? | Heilig M et al. | — | 2019 | → |
| Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. | Gaucher J et al. | — | 2019 | → |
| Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene. | Foo JC et al. | — | 2019 | → |
| GLAST (GLutamate and ASpartate Transporter) in human prefrontal cortex; interactome in healthy brains and the expression of GLAST in brains of chronic alcoholics. | Kashem MA et al. | — | 2019 | → |
| Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans. | Gangisetty O et al. | — | 2019 | → |
| NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward. | Logan RW et al. | — | 2019 | → |
| Neurogenetic basis for circadian regulation of metabolism by the hypothalamus. | Cedernaes J et al. | — | 2019 | → |
| Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. | Sarkar DK et al. | — | 2019 | → |
| Prevalence and safety of acamprosate use in pregnant alcohol-dependent women in New South Wales, Australia. | Kelty E et al. | — | 2019 | → |
| Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D). | Xu P et al. | — | 2019 | → |
| The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice. | Kim M et al. | — | 2019 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults. | Kim J et al. | — | 2018 | → |
| Biological Clocks and Rhythms of Anger and Aggression. | Hood S et al. | — | 2018 | → |
| Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice. | Pradhan G et al. | — | 2018 | → |
| Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury. | Davis BT et al. | — | 2018 | → |
| Circadian Regulation of Glutamate Transporters. | Chi-Castañeda D et al. | — | 2018 | → |
| Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse. | Banach E et al. | — | 2018 | → |
| Deep sequencing and miRNA profiles in alcohol-induced neuroinflammation and the TLR4 response in mice cerebral cortex. | Ureña-Peralta JR et al. | — | 2018 | → |
| Drinking in the morning versus evening: Time-dependent differential effects of acute alcohol administration on the behavior of zebrafish. | Tsang B et al. | — | 2018 | → |
| Effects of alcohol and psychostimulants on the vasopressin system: behavioral implications. | Godino A et al. | — | 2018 | → |
| Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level. | van den Brink W et al. | — | 2018 | → |
| Glial Cells in the Genesis and Regulation of Circadian Rhythms. | Chi-Castañeda D et al. | — | 2018 | → |
| Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents. | Logan RW et al. | — | 2018 | → |
| Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking. | Ezquer F et al. | — | 2018 | → |
| Involvement of Activated Brain Stress Responsive Systems in Excessive and "Relapse" Alcohol Drinking in Rodent Models: Implications for Therapeutics. | Zhou Y et al. | — | 2018 | → |
| Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. | Edwards AC et al. | — | 2018 | → |
| Molecular Neuropathology of Astrocytes and Oligodendrocytes in Alcohol Use Disorders. | Miguel-Hidalgo JJ | — | 2018 | → |
| Naloxone precipitated morphine withdrawal and clock genes expression in striatum: A comparative study in three different protocols for the development of morphine dependence. | Roy K et al. | — | 2018 | → |
| Neurobiological Functions of the Period Circadian Clock 2 Gene, <i>Per2</i>. | Kim M et al. | — | 2018 | → |
| Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs. | Kinoshita C et al. | — | 2018 | → |
| Photoperiod-Induced Neuroplasticity in the Circadian System. | Porcu A et al. | — | 2018 | → |
| Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way. | Huber SE et al. | — | 2018 | → |
| Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. | Dong E et al. | — | 2018 | → |
| Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations. | Almli LM et al. | — | 2018 | → |
| Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder. | Lindberg D et al. | — | 2018 | → |
| Racing the clock: The role of circadian rhythmicity in addiction across the lifespan. | Gulick D et al. | — | 2018 | → |
| The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction. | Freyberg Z et al. | — | 2018 | → |
| Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster. | De Nobrega AK et al. | — | 2017 | → |
| Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling. | Barca-Mayo O et al. | — | 2017 | → |
| Behavioral and transcriptional patterns of protracted opioid self-administration in mice. | Skupio U et al. | — | 2017 | → |
| Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus. | Vadnie CA et al. | — | 2017 | → |
| Circadian Rhythms and Substance Abuse: Chronobiological Considerations for the Treatment of Addiction. | Webb IC | — | 2017 | → |
| Circadian rhythms of hedonic drinking behavior in mice. | Bainier C et al. | — | 2017 | → |
| Dynamical state transitions into addictive behaviour and their early-warning signals. | Foo JC et al. | — | 2017 | → |
| Guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism, first revision. | Soyka M et al. | — | 2017 | → |
| High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. | Crabbe JC et al. | — | 2017 | → |
| Homeostasis of the Intraparenchymal-Blood Glutamate Concentration Gradient: Maintenance, Imbalance, and Regulation. | Bai W et al. | — | 2017 | → |
| <i>Drosophila</i>: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. | De Nobrega AK et al. | — | 2017 | → |
| Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats. | Takahashi TT et al. | — | 2017 | → |
| Metabolomics biomarkers to predict acamprosate treatment response in alcohol-dependent subjects. | Hinton DJ et al. | — | 2017 | → |
| mPer1 promotes morphine-induced locomotor sensitization and conditioned place preference via histone deacetylase activity. | Perreau-Lenz S et al. | — | 2017 | → |
| Pharmacotherapy of alcoholism - an update on approved and off-label medications. | Soyka M et al. | — | 2017 | → |
| Rev-erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice. | Feillet CA et al. | — | 2017 | → |
| The Clock Gene Rev-Erbα Regulates Methamphetamine Actions on Circadian Timekeeping in the Mouse Brain. | Salaberry NL et al. | — | 2017 | → |
| The Role of Mammalian Glial Cells in Circadian Rhythm Regulation. | Chi-Castañeda D et al. | — | 2017 | → |
| Clock Genes in Glia Cells: A Rhythmic History. | Chi-Castañeda D et al. | — | 2016 | → |
| Decreased rates of operant food self-administration are associated with reward deficits in high-fat feeding mice. | Íbias J et al. | — | 2016 | → |
| Dim light at night prior to adolescence increases adult anxiety-like behaviors. | Cissé YM et al. | — | 2016 | → |
| Disentangling the Role of Astrocytes in Alcohol Use Disorder. | Adermark L et al. | — | 2016 | → |
| Disruption of Integrated Neuronal and Astrocytic Signaling Contributes to Alcohol Use Disorder. | Lindberg D et al. | — | 2016 | → |
| Effect of circadian rhythm disturbance on morphine preference and addiction in male rats: Involvement of period genes and dopamine D1 receptor. | Garmabi B et al. | — | 2016 | → |
| Genes and Alcohol Consumption: Studies with Mutant Mice. | Mayfield J et al. | — | 2016 | → |
| I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research. | Narayanan AS et al. | — | 2016 | → |
| Molecular mechanisms underlying alcohol-drinking behaviours. | Ron D et al. | — | 2016 | → |
| Mutations in the circadian gene period alter behavioral and biochemical responses to ethanol in Drosophila. | Liao J et al. | — | 2016 | → |
| Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF). | Jadhav V et al. | — | 2016 | → |
| Possible involvement of the circadian pathway in alcohol use disorder in a South African adolescent cohort. | Dalvie S et al. | — | 2016 | → |
| The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research. | Heilig M et al. | — | 2016 | → |
| What the alcohol doctor ordered from the neuroscientist: Theragnostic biomarkers for personalized treatments. | Heilig M et al. | — | 2016 | → |
| Acamprosate: A Review of Its Use in Alcohol Dependence. | Plosker GL | — | 2015 | → |
| Advances in Medications and Tailoring Treatment for Alcohol Use Disorder. | Seneviratne C et al. | — | 2015 | → |
| Alcohol and lithium have opposing effects on the period and phase of the behavioral free-running activity rhythm. | Nascimento NF et al. | — | 2015 | → |
| Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches. | Prosser RA et al. | — | 2015 | → |
| Chronic shifts in the length and phase of the light cycle increase intermittent alcohol drinking in C57BL/6J mice. | Gamsby JJ et al. | — | 2015 | → |
| Chronobiology of ethanol: animal models. | Rosenwasser AM | — | 2015 | → |
| Circadian clock genes: effects on dopamine, reward and addiction. | Parekh PK et al. | — | 2015 | → |
| Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity. | Parekh PK et al. | — | 2015 | → |
| Circadian rhythms, alcohol and gut interactions. | Forsyth CB et al. | — | 2015 | → |
| Clock genes: from Drosophila to humans. | Rouyer F | — | 2015 | → |
| Clock genes in human alcohol abuse and comorbid conditions. | Partonen T | — | 2015 | → |
| Clock genes × stress × reward interactions in alcohol and substance use disorders. | Perreau-Lenz S et al. | — | 2015 | → |
| Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. | Ozburn AR et al. | — | 2015 | → |
| Dissociation between diurnal cycles in locomotor activity, feeding behavior and hepatic PERIOD2 expression in chronic alcohol-fed mice. | Zhou P et al. | — | 2015 | → |
| Diurnal and circadian regulation of reward-related neurophysiology and behavior. | Webb IC et al. | — | 2015 | → |
| Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats. | Doyle SE et al. | — | 2015 | → |
| Elevated baseline serum glutamate as a pharmacometabolomic biomarker for acamprosate treatment outcome in alcohol-dependent subjects. | Nam HW et al. | — | 2015 | → |
| Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders. | Liu C et al. | — | 2015 | → |
| GLAST But Not Least--Distribution, Function, Genetics and Epigenetics of L-Glutamate Transport in Brain--Focus on GLAST/EAAT1. | Šerý O et al. | — | 2015 | → |
| Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei. | Leone MJ et al. | — | 2015 | → |
| Insights into the Role of the Habenular Circadian Clock in Addiction. | Salaberry NL et al. | — | 2015 | → |
| Quantification of alcohol drinking patterns in mice. | Eisenhardt M et al. | — | 2015 | → |
| Sleep and circadian contributions to adolescent alcohol use disorder. | Hasler BP et al. | — | 2015 | → |
| Small RNA Detection by in Situ Hybridization Methods. | Urbanek MO et al. | — | 2015 | → |
| The induction of Per1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes. | Morioka N et al. | — | 2015 | → |
| The Molecular Circadian Clock and Alcohol-Induced Liver Injury. | Udoh US et al. | — | 2015 | → |
| Acamprosate: an alcoholism treatment that may not be what we thought. | Heilig M | — | 2014 | → |
| Acamprosate produces its anti-relapse effects via calcium. | Spanagel R et al. | — | 2014 | → |
| Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. | Ruby CL et al. | — | 2014 | → |
| Circadian clock and stress interactions in the molecular biology of psychiatric disorders. | Landgraf D et al. | — | 2014 | → |
| Circadian rhythms and addiction: mechanistic insights and future directions. | Logan RW et al. | — | 2014 | → |
| Circadian rhythms and risk for substance use disorders in adolescence. | Hasler BP et al. | — | 2014 | → |
| Fetal alcohol exposure disrupts metabolic signaling in hypothalamic proopiomelanocortin neurons via a circadian mechanism in male mice. | Agapito MA et al. | — | 2014 | → |
| Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate. | Karpyak VM et al. | — | 2014 | → |
| Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity? | Niciu MJ et al. | — | 2014 | → |
| Glycogen synthase kinase-3β in the ventral tegmental area mediates diurnal variations in cocaine-induced conditioned place preference in rats. | Li SX et al. | — | 2014 | → |
| Minutes, days and years: molecular interactions among different scales of biological timing. | Golombek DA et al. | — | 2014 | → |
| Neurotransmitters in alcoholism: A review of neurobiological and genetic studies. | Banerjee N | — | 2014 | → |
| [Pharmacological profiles and clinical roles of acamprosate (Regtect(®) tablets 333 mg) for the maintenance of abstinence in alcohol-dependent patients]. | Ohhara T et al. | — | 2014 | → |
| Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. | Banerjee S et al. | — | 2014 | → |
| Predicting naltrexone response in alcohol-dependent patients: the contribution of functional magnetic resonance imaging. | Mann K et al. | — | 2014 | → |
| Sleep and substance use disorders: an update. | Conroy DA et al. | — | 2014 | → |
| Stratified medicine for mental disorders. | Schumann G et al. | — | 2014 | → |
| Stress and alcohol interactions: animal studies and clinical significance. | Spanagel R et al. | — | 2014 | → |
| The development of acamprosate as a treatment against alcohol relapse. | Kufahl PR et al. | — | 2014 | → |
| Acamprosate {monocalcium bis(3-acetamidopropane-1-sulfonate)} reduces ethanol-drinking behavior in rats and glutamate-induced toxicity in ethanol-exposed primary rat cortical neuronal cultures. | Oka M et al. | — | 2013 | → |
| Addiction and the adrenal cortex. | Vinson GP et al. | — | 2013 | → |
| Advanced transgenic approaches to understand alcohol-related phenotypes in animals. | Bilbao A | — | 2013 | → |
| Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. | Ding ZM et al. | — | 2013 | → |
| An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype. | Hasler BP et al. | — | 2013 | → |
| Association of PER2 genotype and stressful life events with alcohol drinking in young adults. | Blomeyer D et al. | — | 2013 | → |
| Behavioral characteristics and pharmacological manipulations of a nicotine-entrainable circadian oscillator. | Gillman AG et al. | — | 2013 | → |
| Characterization and modeling of intermittent locomotor dynamics in clock gene-deficient mice. | Nakamura T et al. | — | 2013 | → |
| Chronobiology of alcohol: studies in C57BL/6J and DBA/2J inbred mice. | Rosenwasser AM et al. | — | 2013 | → |
| Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders. | McCarthy MJ et al. | — | 2013 | → |
| Circadian clocks and mood-related behaviors. | Albrecht U | — | 2013 | → |
| Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol. | Voigt RM et al. | — | 2013 | → |
| Circadian genes differentially affect tolerance to ethanol in Drosophila. | Pohl JB et al. | — | 2013 | → |
| Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior. | Spencer S et al. | — | 2013 | → |
| Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. | Tapocik JD et al. | — | 2013 | → |
| Differential regulation of the period genes in striatal regions following cocaine exposure. | Falcon E et al. | — | 2013 | → |
| Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation. | Summa KC et al. | — | 2013 | → |
| Diversity of human clock genotypes and consequences. | Zhang L et al. | — | 2013 | → |
| Effect of amphetamine on the clock gene expression in rat striatum. | Wongchitrat P et al. | — | 2013 | → |
| Effects of alcohol on the endocrine system. | Rachdaoui N et al. | — | 2013 | → |
| Egr1 regulates lithium-induced transcription of the Period 2 (PER2) gene. | Kim SH et al. | — | 2013 | → |
| Evidence for possible period 2 gene mediation of the effects of alcohol exposure during the postnatal period on genes associated with maintaining metabolic signaling in the mouse hypothalamus. | Agapito MA et al. | — | 2013 | → |
| Glutamatergic targets for new alcohol medications. | Holmes A et al. | — | 2013 | → |
| High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. | Crews FT et al. | — | 2013 | → |
| Invertebrate models in addiction research. | Søvik E et al. | — | 2013 | → |
| Larval ethanol exposure alters free-running circadian rhythm and per Locus transcription in adult D. melanogaster period mutants. | Ahmad ST et al. | — | 2013 | → |
| Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects. | Ait-Hmyed O et al. | — | 2013 | → |
| Modeling and validating chronic pharmacological manipulation of circadian rhythms. | Kim JK et al. | — | 2013 | → |
| Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow. | Bhatwadekar AD et al. | — | 2013 | → |
| Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. | Forsyth CB et al. | — | 2013 | → |
| Selective breeding for ethanol-related traits alters circadian phenotype. | McCulley WD et al. | — | 2013 | → |
| The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels. | Gamsby JJ et al. | — | 2013 | → |
| The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine. | Bernardi RE et al. | — | 2013 | → |
| The mPer2 clock gene modulates cocaine actions in the mouse circadian system. | Brager AJ et al. | — | 2013 | → |
| The role of clock in ethanol-related behaviors. | Ozburn AR et al. | — | 2013 | → |
| The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats. | Vengeliene V et al. | — | 2013 | → |
| A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome. | Garcia-Rios A et al. | — | 2012 | → |
| A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. | Wang X et al. | — | 2012 | → |
| Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice. | Melendez RI et al. | — | 2012 | → |
| Circadian genes, the stress axis, and alcoholism. | Sarkar DK | — | 2012 | → |
| Circadian rhythms, sleep, and substance abuse. | Hasler BP et al. | — | 2012 | → |
| Clock gene variants in mood and anxiety disorders. | Partonen T | — | 2012 | → |
| Cocaine modulates pathways for photic and nonphotic entrainment of the mammalian SCN circadian clock. | Glass JD et al. | — | 2012 | → |
| Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study. | Broms U et al. | — | 2012 | → |
| Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption. | McBride WJ et al. | — | 2012 | → |
| Genetic insights on sleep schedules: this time, it's PERsonal. | Chong SY et al. | — | 2012 | → |
| Glutamatergic medications for the treatment of drug and behavioral addictions. | Olive MF et al. | — | 2012 | → |
| Inborn differences in environmental reactivity predict divergent diurnal behavioral, endocrine, and gene expression rhythms. | Kerman IA et al. | — | 2012 | → |
| Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. | Perreau-Lenz S et al. | — | 2012 | → |
| Integration of the circadian and stress systems: influence of neuropeptides and implications for alcohol consumption. | Wong CC et al. | — | 2012 | → |
| Interaction of central and peripheral clocks in physiological regulation. | Barclay JL et al. | — | 2012 | → |
| MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex. | Hermann D et al. | — | 2012 | → |
| Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. | Blednov YA et al. | — | 2012 | → |
| PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents. | Forbes EE et al. | — | 2012 | → |
| Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats. | Bahi A et al. | — | 2012 | → |
| Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. | Karlsson RM et al. | — | 2012 | → |
| Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice. | Morioka N et al. | — | 2012 | → |
| The circadian clock component PERIOD2: from molecular to cerebral functions. | Ripperger JA et al. | — | 2012 | → |
| The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure. | Koresh O et al. | — | 2012 | → |
| Timing to perfection: the biology of central and peripheral circadian clocks. | Albrecht U | — | 2012 | → |
| Acamprosate reduces ethanol drinking behaviors and alters the metabolite profile in mice lacking ENT1. | Lee MR et al. | — | 2011 | → |
| Acamprosate-responsive brain sites for suppression of ethanol intake and preference. | Brager A et al. | — | 2011 | → |
| Association of inflammation genes with alcohol dependence/abuse: a systematic review and a meta-analysis. | Kebir O et al. | — | 2011 | → |
| Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice. | Brager AJ et al. | — | 2011 | → |
| Circadian modulation of acute alcohol sensitivity but not acute tolerance in Drosophila. | van der Linde K et al. | — | 2011 | → |
| Circadian rhythms and mood regulation: insights from pre-clinical models. | McClung CA | — | 2011 | → |
| Clock gene mPer2 functions in diurnal variation of acetaminophen induced hepatotoxicity in mice. | Kakan X et al. | — | 2011 | → |
| Continuous versus discontinuous drinking of an ethanol liquid diet in peripubertal rats: effect on 24-h variation of lymph node and splenic mitogenic responses and lymphocyte subset populations. | Jiménez-Ortega V et al. | — | 2011 | → |
| Daily morphine injection and withdrawal disrupt 24-h wheel running and PERIOD2 expression patterns in the rat limbic forebrain. | Hood S et al. | — | 2011 | → |
| Drugs as instruments: a new framework for non-addictive psychoactive drug use. | Müller CP et al. | — | 2011 | → |
| Ethanol consumption in mice: relationships with circadian period and entrainment. | Trujillo JL et al. | — | 2011 | → |
| Evening types are more often current smokers and nicotine-dependent-a study of Finnish adult twins. | Broms U et al. | — | 2011 | → |
| Glial cell modulation of circadian rhythms. | Jackson FR | — | 2011 | → |
| Global depletion of dopamine using intracerebroventricular 6-hydroxydopamine injection disrupts normal circadian wheel-running patterns and PERIOD2 expression in the rat forebrain. | Gravotta L et al. | — | 2011 | → |
| HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions. | Persidsky Y et al. | — | 2011 | → |
| Implication of the purinergic system in alcohol use disorders. | Asatryan L et al. | — | 2011 | → |
| Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice. | Nakamura M et al. | — | 2011 | → |
| Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele. | Daan S et al. | — | 2011 | → |
| Mammalian molecular clocks. | Kwon I et al. | — | 2011 | → |
| mGluR7 genetics and alcohol: intersection yields clues for addiction. | Gyetvai B et al. | — | 2011 | → |
| Modulation of monoamine receptors by adaptor proteins and lipid rafts: role in some effects of centrally acting drugs and therapeutic agents. | Björk K et al. | — | 2011 | → |
| Noradrenergic regulation of period1 expression in spinal astrocytes is involved in protein kinase A, c-Jun N-terminal kinase and extracellular signal-regulated kinase activation mediated by α1- and β2-adrenoceptors. | Sugimoto T et al. | — | 2011 | → |
| No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population. | Kishi T et al. | — | 2011 | → |
| Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery. | Comasco E et al. | — | 2011 | → |
| Role of intestinal circadian genes in alcohol-induced gut leakiness. | Swanson G et al. | — | 2011 | → |
| Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms. | Harvey AG et al. | — | 2011 | → |
| The circadian clock, reward, and memory. | Albrecht U | — | 2011 | → |
| The clock gene Per2 is required for normal platelet formation and function. | Zhao Y et al. | — | 2011 | → |
| The daily rhythm of mice. | Ripperger JA et al. | — | 2011 | → |
| When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. | Menet JS et al. | — | 2011 | → |
| A clockwork liver: Time for liver injury and repair. | Togashi H | — | 2010 | → |
| Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. | Chen J et al. | — | 2010 | → |
| An association analysis of circadian genes in anxiety disorders. | Sipilä T et al. | — | 2010 | → |
| An essential role for adenosine signaling in alcohol abuse. | Ruby CL et al. | — | 2010 | → |
| An integrated genome research network for studying the genetics of alcohol addiction. | Spanagel R et al. | — | 2010 | → |
| Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. | Ando H et al. | — | 2010 | → |
| Chronic ethanol disrupts circadian photic entrainment and daily locomotor activity in the mouse. | Brager AJ et al. | — | 2010 | → |
| Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. | Kovanen L et al. | — | 2010 | → |
| Circadian clock genes: non-circadian roles in sleep, addiction, and psychiatric disorders? | Rosenwasser AM | — | 2010 | → |
| Circadian clocks: genes, sleep, and cognition. | Kyriacou CP et al. | — | 2010 | → |
| Circadian clocks in mood-related behaviors. | Albrecht U | — | 2010 | → |
| CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. | Sjöholm LK et al. | — | 2010 | → |
| Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2. | Perreau-Lenz S et al. | — | 2010 | → |
| Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. | Umhau JC et al. | — | 2010 | → |
| Effects of repeated light-dark phase shifts on voluntary ethanol and water intake in male and female Fischer and Lewis rats. | Rosenwasser AM et al. | — | 2010 | → |
| Emerging drugs to treat alcoholism. | Soyka M et al. | — | 2010 | → |
| Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. | Hood S et al. | — | 2010 | → |
| ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytes. | Wu J et al. | — | 2010 | → |
| Environmental modulation of alcohol intake in hamsters: effects of wheel running and constant light exposure. | Hammer SB et al. | — | 2010 | → |
| Glycine receptors in the nucleus accumbens involved in the ethanol intake-reducing effect of acamprosate. | Chau P et al. | — | 2010 | → |
| Glycine receptors involved in acamprosate's modulation of accumbal dopamine levels: an in vivo microdialysis study. | Chau P et al. | — | 2010 | → |
| Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. | Vengeliene V et al. | — | 2010 | → |
| Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania. | Dzirasa K et al. | — | 2010 | → |
| Loss of clock gene mPer2 promotes liver fibrosis induced by carbon tetrachloride. | Chen P et al. | — | 2010 | → |
| Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta). | Morioka N et al. | — | 2010 | → |
| Period 2 gene deletion abolishes beta-endorphin neuronal response to ethanol. | Agapito M et al. | — | 2010 | → |
| Persistent gene expression changes in ventral tegmental area of adolescent but not adult rats in response to chronic nicotine. | Doura MB et al. | — | 2010 | → |
| Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1. | Nam HW et al. | — | 2010 | → |
| Reduced expression of circadian clock genes in male alcoholic patients. | Huang MC et al. | — | 2010 | → |
| Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. | Wulff K et al. | — | 2010 | → |
| The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents. | Comasco E et al. | — | 2010 | → |
| The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation. | Maronde E et al. | — | 2010 | → |
| The effects of alcoholism on the human basolateral amygdala. | Kryger R et al. | — | 2010 | → |
| The mammalian circadian timing system: organization and coordination of central and peripheral clocks. | Dibner C et al. | — | 2010 | → |
| Using glutamate homeostasis as a target for treating addictive disorders. | Reissner KJ et al. | — | 2010 | → |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | — | 2009 | → |
| A role for the circadian genes in drug addiction. | Falcón E et al. | — | 2009 | → |
| Behavioral and hormonal regulation of expression of the clock protein, PER2, in the central extended amygdala. | Amir S et al. | — | 2009 | → |
| Brain clocks: from the suprachiasmatic nuclei to a cerebral network. | Mendoza J et al. | — | 2009 | → |
| Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D-aspartate receptors. | Alén F et al. | — | 2009 | → |
| Chronic alcohol treatment in rats alters sleep by fragmenting periods of vigilance cycling in the light period with extended wakenings. | Mukherjee S et al. | — | 2009 | → |
| Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster. | Ruby CL et al. | — | 2009 | → |
| Chronic ethanol intake alters circadian phase shifting and free-running period in mice. | Seggio JA et al. | — | 2009 | → |
| Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. | Beaulé C et al. | — | 2009 | → |
| Circadian regulation of central ethanol sensitivity by the mPer2 gene. | Perreau-Lenz S et al. | — | 2009 | → |
| Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in C57 mice. | Trujillo JL et al. | — | 2009 | → |
| Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. | von der Goltz C et al. | — | 2009 | → |
| Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals. | Gillman AG et al. | — | 2009 | → |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | — | 2009 | → |
| Identifying the neural circuitry of alcohol craving and relapse vulnerability. | Heinz A et al. | — | 2009 | → |
| Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats. | Miguel-Hidalgo J et al. | — | 2009 | → |
| microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. | Chandrasekar V et al. | — | 2009 | → |
| Motivational Modulation of Rhythms of the Expression of the Clock Protein PER2 in the Limbic Forebrain. | Amir S et al. | — | 2009 | → |
| NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. | Englund A et al. | — | 2009 | → |
| The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity. | Chen P et al. | — | 2009 | → |
| The Role of Glial Cells in Drug Abuse. | Miguel-Hidalgo JJ | — | 2009 | → |
| The role of mPer2 clock gene in glucocorticoid and feeding rhythms. | Yang S et al. | — | 2009 | → |
| Acamprosate: recent findings and future research directions. | Mann K et al. | — | 2008 | → |
| Alcohol preference in mice lacking the Avpr1a vasopressin receptor. | Sanbe A et al. | — | 2008 | → |
| Circadian phenotype in patients with the co-morbid alcohol use and bipolar disorders. | Hätönen T et al. | — | 2008 | → |
| Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats. | Adams CL et al. | — | 2008 | → |
| Double-stranded RNA-mediated suppression of Period2 expression in the suprachiasmatic nucleus disrupts circadian locomotor activity in rats. | Gavrila AM et al. | — | 2008 | → |
| Drugs for relapse prevention of alcoholism: ten years of progress. | Spanagel R et al. | — | 2008 | → |
| Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. | Reilly MT et al. | — | 2008 | → |
| GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. | Soyka M et al. | — | 2008 | → |
| Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection. | Cruciani F et al. | — | 2008 | → |
| Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology. | Paz RD et al. | — | 2008 | → |
| Glutamatergic substrates of drug addiction and alcoholism. | Gass JT et al. | — | 2008 | → |
| Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex. | Flatscher-Bader T et al. | — | 2008 | → |
| Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. | Wang CY et al. | — | 2008 | → |
| Neurobiology of alcohol dependence: focus on motivational mechanisms. | Gilpin NW et al. | — | 2008 | → |
| Neuropharmacology of alcohol addiction. | Vengeliene V et al. | — | 2008 | → |
| Neuroplasticity mediated by altered gene expression. | McClung CA et al. | — | 2008 | → |
| Novel neurons in ventral tegmental area fire selectively during the active phase of the diurnal cycle. | Luo AH et al. | — | 2008 | → |
| Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. | Hampp G et al. | — | 2008 | → |
| Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. | Wong CC et al. | — | 2008 | → |
| Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients. | Puls I et al. | — | 2008 | → |
| The circadian clock and mood-related behavior. | Hampp G et al. | — | 2008 | → |
| The genetics of mammalian circadian order and disorder: implications for physiology and disease. | Takahashi JS et al. | — | 2008 | → |
| The systems view in addiction research. | Gebicke-Haerter PJ et al. | — | 2008 | → |
| When clocks go bad: neurobehavioural consequences of disrupted circadian timing. | Barnard AR et al. | — | 2008 | → |
| Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats. | Bowers MS et al. | — | 2007 | → |
| Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster. | Seggio JA et al. | — | 2007 | → |
| Circadian genes, rhythms and the biology of mood disorders. | McClung CA | — | 2007 | → |
| Clock genes running amok. Clock genes and their role in drug addiction and depression. | Perreau-Lenz S et al. | — | 2007 | → |
| Contribution of the suprachiasmatic nucleus to day:night variation in cocaine-seeking behavior. | Sleipness EP et al. | — | 2007 | → |
| Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland. | Qu X et al. | — | 2007 | → |
| Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice. | Zghoul T et al. | — | 2007 | → |
| Evidence for the role of dopamine D3 receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in mice. | Heidbreder CA et al. | — | 2007 | → |
| Genetic research with intermediate phenotypes: phenocopies, perspectives and pitfalls. | Heinz A et al. | — | 2007 | → |
| Heritability of diurnal type: a nationwide study of 8753 adult twin pairs. | Koskenvuo M et al. | — | 2007 | → |
| Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. | Füllgrabe MW et al. | — | 2007 | → |
| Melatonin enhances the rewarding properties of morphine: involvement of the nitric oxidergic pathway. | Yahyavi-Firouz-Abadi N et al. | — | 2007 | → |
| Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction. | Esquifino AI et al. | — | 2007 | → |
| Okey Lecture 2006: identifying the neurobiological mechanisms of addictive behaviour. | Schumann G | — | 2007 | → |
| Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. | Morozova TV et al. | — | 2007 | → |
| Preclinical and clinical pharmacology of alcohol dependence. | Tambour S et al. | — | 2007 | → |
| Repeated light-dark phase shifts modulate voluntary ethanol intake in male and female high alcohol-drinking (HAD1) rats. | Clark JW et al. | — | 2007 | → |
| The effects of lamotrigine on alcohol seeking and relapse. | Vengeliene V et al. | — | 2007 | → |
| The multiple facets of Per2. | Albrecht U et al. | — | 2007 | → |
| The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. | Kondratov RV et al. | — | 2007 | → |
| Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. | Partonen T et al. | — | 2007 | → |
| Treatment of addiction in the era of genomic medicine. | O'Brien C | — | 2007 | → |
| What can a clock mutation in mice tell us about bipolar disorder? | Coyle JT | — | 2007 | → |
| Alcohol-related genes: contributions from studies with genetically engineered mice. | Crabbe JC et al. | — | 2006 | → |
| Alterations in circadian rhythm phase shifting ability in rats following ethanol exposure during the third trimester brain growth spurt. | Sakata-Haga H et al. | — | 2006 | → |
| Attenuation of cocaine-induced reinstatement of cocaine conditioned place preference by acamprosate. | Mcgeehan AJ et al. | — | 2006 | → |
| Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. | Sanchis-Segura C et al. | — | 2006 | → |
| Central and peripheral clocks in cardiovascular and metabolic function. | Curtis AM et al. | — | 2006 | → |
| Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequilibrium in eukaryote genomes using frequency distribution curves. | Berendzen KW et al. | — | 2006 | → |
| Clock genes: influencing and being influenced by psychoactive drugs. | Manev H et al. | — | 2006 | → |
| [Cue-induced alcohol craving. Neurobiological correlates and clinical relevance]. | Wrase J et al. | — | 2006 | → |
| Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. | Yelamanchili SV et al. | — | 2006 | → |
| Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. | Kondratov RV et al. | — | 2006 | → |
| [Factors influencing juvenile alcohol consumption: the role of gene-environment interactions]. | Hinckers AS et al. | — | 2006 | → |
| Hypocretins: the timing of sleep and waking. | Selbach O et al. | — | 2006 | → |
| Hypothalamic-pituitary-adrenal axis and substance use: so many questions--and we can answer them. | Schumann G | — | 2006 | → |
| Impaired daily glucocorticoid rhythm in Per1 ( Brd ) mice. | Dallmann R et al. | — | 2006 | → |
| Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. | Sanchis-Segura C et al. | — | 2006 | → |
| Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics. | Preuss UW et al. | — | 2006 | → |
| Lack of food anticipation in Per2 mutant mice. | Feillet CA et al. | — | 2006 | → |
| Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment. | Overstreet DH et al. | — | 2006 | → |
| Molecular components of the mammalian circadian clock. | Ko CH et al. | — | 2006 | → |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | — | 2006 | → |
| Orchestration of gene expression and physiology by the circadian clock. | Albrecht U | — | 2006 | → |
| Regulating a circadian clock's period, phase and amplitude by phosphorylation: insights from Drosophila. | Bae K et al. | — | 2006 | → |
| Responses of the steroid circadian system to alcohol in humans: Importance of the time and duration of intake. | Danel T et al. | — | 2006 | → |
| Schedule-induced alcohol drinking: non-selective effects of acamprosate and naltrexone. | Escher T et al. | — | 2006 | → |
| Suprachiasmatic astrocytes as an interface for immune-circadian signalling. | Leone MJ et al. | — | 2006 | → |
| The role of mutagenesis in defining genes in behaviour. | Godinho SI et al. | — | 2006 | → |
| Transcriptional response to alcohol exposure in Drosophila melanogaster. | Morozova TV et al. | — | 2006 | → |
| Addiction and its brain science. | Spanagel R et al. | — | 2005 | → |
| Alcohol consumption and the body's biological clock. | Spanagel R et al. | — | 2005 | → |
| Biological clock: biological clocks may modulate drug addiction. | Yuferov V et al. | — | 2005 | → |
| Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism? | Egli M | — | 2005 | → |
| Circadian activity rhythms in selectively bred ethanol-preferring and nonpreferring rats. | Rosenwasser AM et al. | — | 2005 | → |
| Clinical aspects of human circadian rhythms. | Klerman EB | — | 2005 | → |
| Effect of light/dark cycle alteration on morphine-induced conditioned place preference. | Tahsili-Fahadan P et al. | — | 2005 | → |
| The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system. | Cowen MS et al. | — | 2005 | → |
| The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. | Cowen MS et al. | — | 2005 | → |
| [The NMDA receptor system: genetic risk factor for alcoholism]. | Schumann G et al. | — | 2005 | → |
| The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei. | Vansteensel MJ et al. | — | 2005 | → |
| The "ups and downs" of signaling cascades in addiction. | Ron D et al. | — | 2005 | → |