Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics.
paper
Cited
Public
Unavailable
- Authors
- Mayfield, R Dayne; Lewohl, Joanne M; Dodd, Peter R; Herlihy, Amy; Liu, Jianwen; Harris, R Adron
- Year
- 2002
- Journal
- Journal of neurochemistry
- PMID
- 12065639
- DOI
- 10.1046/j.1471-4159.2002.00860.x
Alcoholism is a major health problem in Western countries, yet relatively little is known about the mechanisms by which chronic alcohol abuse causes the pathologic changes associated with the disease. It is likely that chronic alcoholism affects a number of signaling cascades and transcription factors, which in turn result in distinct gene expression patterns. These patterns are difficult to detect by traditional experiments measuring a few mRNAs at a time, but are well suited to microarray analyses. We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. A functional hierarchy was devised for classification of brain genes and the resulting groups were compared based on differential expression. Comparison of gene expression patterns in these brain regions revealed a selective reprogramming of gene expression in distinct functional groups. The most pronounced differences were found in myelin-related genes and genes involved in protein trafficking. Significant changes in the expression of known alcohol-responsive genes, and genes involved in calcium, cAMP, and thyroid signaling pathways were also identified. These results suggest that multiple pathways may be important for neuropathology and altered neuronal function observed in alcoholism.
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| Long-Term Excessive Alcohol Consumption Enhances Myelination in the Mouse Nucleus Accumbens. | Liran M et al. | β | 2025 | β |
| Variation of Myelin-associated Gene Expression and <i>Ndrg1</i> within the Prefrontal Cortex as Determinants for Initial Level of Response to Alcohol | Wolstenholme JT et al. | β | 2025 | β |
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| Toll-like receptor 7: A novel neuroimmune target to reduce excessive alcohol consumption. | Allard RL et al. | β | 2024 | β |
| Apolipoprotein D as a Potential Biomarker in Neuropsychiatric Disorders. | Del Valle E et al. | β | 2023 | β |
| The neuroimmune system - Where aging and excess alcohol intersect. | Carlson ER et al. | β | 2023 | β |
| Genome-wide transcriptomics of the amygdala reveals similar oligodendrocyte-related responses to acute and chronic alcohol drinking in female mice. | Narendra S et al. | β | 2022 | β |
| Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders. | Casello SM et al. | β | 2022 | β |
| Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. | Mineur YS et al. | β | 2022 | β |
| Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man. | Hime GR et al. | β | 2021 | β |
| Chronic intermittent ethanol and lipopolysaccharide exposure differentially alter Iba1-derived microglia morphology in the prelimbic cortex and nucleus accumbens core of male Long-Evans rats. | Siemsen BM et al. | β | 2021 | β |
| Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4. | Maiya R et al. | β | 2021 | β |
| Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. | Johnstone AL et al. | β | 2021 | β |
| Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome. | Walter N et al. | β | 2021 | β |
| Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. | Lim Y et al. | β | 2021 | β |
| Meta-Analysis on the Association of Neuropeptide Y rs16139 Variant With the Risk of Alcoholism. | Chen B et al. | β | 2021 | β |
| Tissue-specific transcriptome recovery on withdrawal from chronic alcohol exposure in zebrafish. | Banu S et al. | β | 2021 | β |
| Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules. | Cahill CM et al. | β | 2020 | β |
| Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence. | Drake J et al. | β | 2020 | β |
| Behavioral, neurobiological, and neurochemical mechanisms of ethanol self-administration: A translational review. | Vena AA et al. | β | 2020 | β |
| Brain regional gene expression network analysis identifies unique interactions between chronic ethanol exposure and consumption. | Smith ML et al. | β | 2020 | β |
| Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations. | Lowe PP et al. | β | 2020 | β |
| Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. | Socodato R et al. | β | 2020 | β |
| Effects of chronic intermittent ethanol exposure and withdrawal on neuroblastoma cell transcriptome. | McClintick JN et al. | β | 2020 | β |
| Flying Together: <i>Drosophila</i> as a Tool to Understand the Genetics of Human Alcoholism. | Lathen DR et al. | β | 2020 | β |
| Multi-modal imaging reveals differential brain volumetric, biochemical, and white matter fiber responsivity to repeated intermittent ethanol vapor exposure in male and female rats. | Zahr NM et al. | β | 2020 | β |
| Role of toll-like receptor 7 (TLR7) in voluntary alcohol consumption. | Grantham EK et al. | β | 2020 | β |
| Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance. | Radcliffe RA et al. | β | 2020 | β |
| The Effect of Chronic Ethanol Exposure and Thiamine Deficiency on Myelin-related Genes in the Cortex and the Cerebellum. | Chatterton BJ et al. | β | 2020 | β |
| Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation. | Ruan H et al. | β | 2019 | β |
| Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder. | Salvatore JE et al. | β | 2019 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders. | Melbourne JK et al. | β | 2019 | β |
| Neuroimmune signaling in alcohol use disorder. | Erickson EK et al. | β | 2019 | β |
| Transgeneratonal inheritance of ethanol preference is caused by maternal NPF repression. | Bozler J et al. | β | 2019 | β |
| Adenosine deaminase activity and gene expression patterns are altered after chronic ethanol exposure in zebrafish brain. | Rico EP et al. | β | 2018 | β |
| Copper Binding Induces Nitration of NPY under Nitrative Stress: Complicating the Role of NPY in Alzheimer's Disease. | Ye H et al. | β | 2018 | β |
| Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking. | McClintick JN et al. | β | 2018 | β |
| Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence. | van der Vaart A et al. | β | 2018 | β |
| Molecular Neuropathology of Astrocytes and Oligodendrocytes in Alcohol Use Disorders. | Miguel-Hidalgo JJ | β | 2018 | β |
| On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. | Iancu OD et al. | β | 2018 | β |
| Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats. | Alsebaaly J et al. | β | 2018 | β |
| Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. | Kalinin S et al. | β | 2018 | β |
| Chronic intermittent ethanol exposure selectively alters the expression of GΞ± subunit isoforms and RGS subtypes in rat prefrontal cortex. | Luessen DJ et al. | β | 2017 | β |
| Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4T. | Zou Y et al. | β | 2017 | β |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | β | 2017 | β |
| How Should Remote Clinical Monitoring Be Used to Treat Alcohol Use Disorders?: Initial Findings From an Expert Round Table Discussion. | Gordon A et al. | β | 2017 | β |
| Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders. | Zahr NM et al. | β | 2017 | β |
| Transcriptional profiling of the rat nucleus accumbens after modest or high alcohol exposure. | Morud J et al. | β | 2017 | β |
| Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway. | Troutwine BR et al. | β | 2016 | β |
| Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. | McClintick JN et al. | β | 2016 | β |
| RNA Sequencing Reveals the Alteration of the Expression of Novel Genes in Ethanol-Treated Embryoid Bodies. | Mandal C et al. | β | 2016 | β |
| Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption. | Most D et al. | β | 2016 | β |
| The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies. | Warden A et al. | β | 2016 | β |
| A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue. | Elsayed M et al. | β | 2015 | β |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | β | 2015 | β |
| Ethanol intake-induced apoptosis in glial cells and axonal disorders in the cerebellar white matter of UChA rats (voluntary ethanol consumers). | Martinez M et al. | β | 2015 | β |
| Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling. | Wilhelm CJ et al. | β | 2015 | β |
| Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking. | McClintick JN et al. | β | 2015 | β |
| Gene expression profile analysis of rat cerebellum under acute alcohol intoxication. | Zhang Y et al. | β | 2015 | β |
| Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. | Mamdani M et al. | β | 2015 | β |
| Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila. | Morozova TV et al. | β | 2015 | β |
| Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. | Finegersh A et al. | β | 2015 | β |
| Sensitive biomarkers of alcoholism's effect on brain macrostructure: similarities and differences between France and the United States. | Le Berre AP et al. | β | 2015 | β |
| The neurometabolic fingerprint of excessive alcohol drinking. | Meinhardt MW et al. | β | 2015 | β |
| The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol. | Most D et al. | β | 2015 | β |
| Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. | Finegersh A et al. | β | 2014 | β |
| Comorbidities, confounders, and the white matter transcriptome in chronic alcoholism. | Sutherland GT et al. | β | 2014 | β |
| Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. | Zhang H et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. | Manzardo AM et al. | β | 2014 | β |
| GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics. | Bhandage AK et al. | β | 2014 | β |
| Genetic risk prediction and neurobiological understanding of alcoholism. | Levey DF et al. | β | 2014 | β |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | β | 2014 | β |
| Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity? | Niciu MJ et al. | β | 2014 | β |
| Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. | Vadnie CA et al. | β | 2014 | β |
| Neuropathology of alcoholism. | Sutherland GT et al. | β | 2014 | β |
| Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics. | Jin Z et al. | β | 2014 | β |
| Using autopsy brain tissue to study alcohol-related brain damage in the genomic age. | Sutherland GT et al. | β | 2014 | β |
| White matter microstructural recovery with abstinence and decline with relapse in alcohol dependence interacts with normal ageing: a controlled longitudinal DTI study. | Pfefferbaum A et al. | β | 2014 | β |
| Association between neuropeptide Y gene polymorphisms and alcohol dependence: a case-control study in two independent populations. | Bhaskar LV et al. | β | 2013 | β |
| Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway. | Pignataro L et al. | β | 2013 | β |
| Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats. | McBride WJ et al. | β | 2013 | β |
| Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. | Tapocik JD et al. | β | 2013 | β |
| Differential Effects of Chronic and Chronic-Intermittent Ethanol Treatment and Its Withdrawal on the Expression of miRNAs. | van Steenwyk G et al. | β | 2013 | β |
| Fyn-dependent gene networks in acute ethanol sensitivity. | Farris SP et al. | β | 2013 | β |
| Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption. | McBride WJ et al. | β | 2013 | β |
| Genome-wide association study of a quantitative disordered gambling trait. | Lind PA et al. | β | 2013 | β |
| Integration of miRNA and protein profiling reveals coordinated neuroadaptations in the alcohol-dependent mouse brain. | Gorini G et al. | β | 2013 | β |
| Modeling the diagnostic criteria for alcohol dependence with genetic animal models. | Crabbe JC et al. | β | 2013 | β |
| Neurobiological signatures of alcohol dependence revealed by protein profiling. | Gorini G et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| The role of Ξ±-synuclein in the pathophysiology of alcoholism. | Janeczek P et al. | β | 2013 | β |
| Time course of SERCA 2b and calreticulin expression in Purkinje neurons of ethanol-fed rats with behavioral correlates. | Cassidy LL et al. | β | 2013 | β |
| Alpha-synuclein and heroin craving in opiate-dependent patients on injectable heroin maintenance. | DΓΌrsteler-MacFarland KM et al. | β | 2012 | β |
| A mouse model for adolescent alcohol abuse: stunted growth and effects in brain. | Huang C et al. | β | 2012 | β |
| Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. | Bhandari P et al. | β | 2012 | β |
| Ethanol modulation of gene networks: implications for alcoholism. | Farris SP et al. | β | 2012 | β |
| Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations. | Hicks SD et al. | β | 2012 | β |
| Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption. | McBride WJ et al. | β | 2012 | β |
| Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain. | Contet C | β | 2012 | β |
| Identifying gene networks underlying the neurobiology of ethanol and alcoholism. | Wolen AR et al. | β | 2012 | β |
| MicroRNAs in Neurotoxicity. | Kaur P et al. | β | 2012 | β |
| Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. | Zhao Z et al. | β | 2012 | β |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | β | 2012 | β |
| Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse. | Alfonso-Loeches S et al. | β | 2012 | β |
| Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. | Acosta G et al. | β | 2011 | β |
| Chronic alcohol exposure induced gene expression changes in the zebrafish brain. | Pan Y et al. | β | 2011 | β |
| Chronic ethanol treatment alters purine nucleotide hydrolysis and nucleotidase gene expression pattern in zebrafish brain. | Rico EP et al. | β | 2011 | β |
| Clinical and pathological features of alcohol-related brain damage. | Zahr NM et al. | β | 2011 | β |
| Differential expression of 14-3-3 isoforms in human alcoholic brain. | MacKay RK et al. | β | 2011 | β |
| Electrically evoked synaptosomal amino acid transmitter release in human brain in alcohol misuse. | Kuo SW et al. | β | 2011 | β |
| Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain. | Zahr NM et al. | β | 2011 | β |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area. | Bernier BE et al. | β | 2011 | β |
| Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics. | Jin Z et al. | β | 2011 | β |
| Up-regulation of microRNAs in brain of human alcoholics. | Lewohl JM et al. | β | 2011 | β |
| Alcohol and the prefrontal cortex. | Abernathy K et al. | β | 2010 | β |
| Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. | Ho AM et al. | β | 2010 | β |
| Callosal microstructural abnormalities in Alzheimer's disease and alcoholism: same phenotype, different mechanisms. | Pitel AL et al. | β | 2010 | β |
| Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking. | McBride WJ et al. | β | 2010 | β |
| Genes associated with alcohol abuse and tobacco smoking in the human nucleus accumbens and ventral tegmental area. | Flatscher-Bader T et al. | β | 2010 | β |
| MicroRNAs: master regulators of ethanol abuse and toxicity? | Miranda RC et al. | β | 2010 | β |
| Therapeutic potential of neuropeptide Y (NPY) receptor ligands. | Brothers SP et al. | β | 2010 | β |
| Transcallosal white matter degradation detected with quantitative fiber tracking in alcoholic men and women: selective relations to dissociable functions. | Pfefferbaum A et al. | β | 2010 | β |
| Using expression genetics to study the neurobiology of ethanol and alcoholism. | Farris SP et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Altered white matter microstructure in adolescent substance users. | Bava S et al. | β | 2009 | β |
| Degradation of association and projection white matter systems in alcoholism detected with quantitative fiber tracking. | Pfefferbaum A et al. | β | 2009 | β |
| Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study. | McBride WJ et al. | β | 2009 | β |
| Effects of forced alcohol drinking on alcohol-water choice in three pairs of rat lines selectively bred for differences in alcohol preference. | Timberlake W et al. | β | 2009 | β |
| ERGR: An ethanol-related gene resource. | Guo AY et al. | β | 2009 | β |
| Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice. | Weng J et al. | β | 2009 | β |
| Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. | Bell RL et al. | β | 2009 | β |
| Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity. | Wang LL et al. | β | 2009 | β |
| Proteomic analysis demonstrates adolescent vulnerability to lasting hippocampal changes following chronic alcohol consumption. | Hargreaves GA et al. | β | 2009 | β |
| Studies on Syntaxin 12 and alcohol preference involving C57BL/6J and DBA/2J strains of mice. | Weng J et al. | β | 2009 | β |
| Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain. | Etheridge N et al. | β | 2009 | β |
| The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience. | Dedova I et al. | β | 2009 | β |
| Toxicogenomics: transcription profiling for toxicology assessment. | Zhou T et al. | β | 2009 | β |
| Unraveling the molecular mechanisms of alcohol dependence. | Kalsi G et al. | β | 2009 | β |
| Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. | Webb KJ et al. | β | 2009 | β |
| Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction. | Feng Y | β | 2008 | β |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | β | 2008 | β |
| Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain". | Sullivan EV et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |
| Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. | Le-Niculescu H et al. | β | 2008 | β |
| Transcriptional correlates of human substance use. | Lehrmann E et al. | β | 2008 | β |
| Translational studies of alcoholism: bridging the gap. | Zahr NM et al. | β | 2008 | β |
| Upregulation of beta-catenin levels in superior frontal cortex of chronic alcoholics. | Al-Housseini AM et al. | β | 2008 | β |
| Acetylcholinesterase inhibitors may improve myelin integrity. | Bartzokis G | β | 2007 | β |
| Analysis of behavior using genetical genomics in mice as a model: from alcohol preferences to gene expression differences. | Singh SM et al. | β | 2007 | β |
| A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. | Alexander-Kaufman K et al. | β | 2007 | β |
| Biomarkers in alcoholism. | NiemelΓ€ O | β | 2007 | β |
| Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. | Rodd ZA et al. | β | 2007 | β |
| CNS proteomes in alcohol and drug abuse and dependence. | Matsumoto I et al. | β | 2007 | β |
| Ethanol-responsive genes: identification of transcription factors and their role in metabolomics. | Uddin RK et al. | β | 2007 | β |
| Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure. | He X et al. | β | 2007 | β |
| Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. | Morozova TV et al. | β | 2007 | β |
| The concentration-dependent effects of ethanol on Caenorhabditis elegans behaviour. | Mitchell PH et al. | β | 2007 | β |
| Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. | Le-Niculescu H et al. | β | 2007 | β |
| Validation of endogenous controls for quantitative gene expression analysis: application on brain cortices of human chronic alcoholics. | Johansson S et al. | β | 2007 | β |
| Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach. | GΓΌndel U et al. | β | 2007 | β |
| Chronic smoking and alcoholism change expression of selective genes in the human prefrontal cortex. | Flatscher-Bader T et al. | β | 2006 | β |
| cis-Regulatory sequences of the genes involved in apoptosis, cell growth, and proliferation may provide a target for some of the effects of acute ethanol exposure. | Uddin RK et al. | β | 2006 | β |
| Comparative gene expression in brain regions of human alcoholics. | Flatscher-Bader T et al. | β | 2006 | β |
| Critical appraisal of DNA microarrays in psychiatric genomics. | Mirnics K et al. | β | 2006 | β |
| Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. | Alexander-Kaufman K et al. | β | 2006 | β |
| Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. | Albertson DN et al. | β | 2006 | β |
| Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism. | Pfefferbaum A et al. | β | 2006 | β |
| Effects of chronic ethanol administration on brain protein levels: a proteomic investigation using 2-D DIGE system. | Damodaran S et al. | β | 2006 | β |
| Ethanol-induced regulation of GABA-A subunit mRNAs in prefrontal fields of cynomolgus monkeys. | Hemby SE et al. | β | 2006 | β |
| Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency. | Donarum EA et al. | β | 2006 | β |
| Increased expression of genes that control ionic homeostasis, second messenger signaling and metabolism in the carotid plaques from patients with symptomatic stroke. | Vemuganti R et al. | β | 2006 | β |
| Integrative strategies to identify candidate genes in rodent models of human alcoholism. | Treadwell JA | β | 2006 | β |
| Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice. | Bowers BJ et al. | β | 2006 | β |
| Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes. | Smith AM et al. | β | 2006 | β |
| Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption. | Okamoto H et al. | β | 2006 | β |
| Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. | Liu J et al. | β | 2006 | β |
| Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. | Goldowitz D et al. | β | 2006 | β |
| Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women. | Pfefferbaum A et al. | β | 2006 | β |
| Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. | Lehrmann E et al. | β | 2006 | β |
| Alcohol and gene expression in the central nervous system. | Worst TJ et al. | β | 2005 | β |
| Alcohol effects on central nervous system gene expression in genetic animal models. | McBride WJ et al. | β | 2005 | β |
| Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. | Flatscher-Bader T et al. | β | 2005 | β |
| Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving. | BΓΆnsch D et al. | β | 2005 | β |
| BRAIN MYELINATION IN PREVALENT NEUROPSYCHIATRIC DEVELOPMENTAL DISORDERS: PRIMARY AND COMORBID ADDICTION. | Bartzokis G | β | 2005 | β |
| Brain region-specific regulation of urocortin 1 innervation and corticotropin-releasing factor receptor type 2 binding by ethanol exposure. | Weitemier AZ et al. | β | 2005 | β |
| Carotid atherosclerotic plaques from symptomatic stroke patients share the molecular fingerprints to develop in a neoplastic fashion: a microarray analysis study. | Vemuganti R et al. | β | 2005 | β |
| Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats. | Duncan EA et al. | β | 2005 | β |
| Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis: the nucleus tractus solitarius. | Covarrubias MY et al. | β | 2005 | β |
| Commentary: Gene-environment interplay in the context of genetics, epigenetics, and gene expression. | Kramer DA | β | 2005 | β |
| Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain. | Lewohl JM et al. | β | 2005 | β |
| Expression Profiling in Alcoholism Research. | Bergeson SE et al. | β | 2005 | β |
| Expression profiling methods used in drug abuse research. | Gebicke-Haerter P | β | 2005 | β |
| Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. | Edenberg HJ et al. | β | 2005 | β |
| Gene expression profiling in the brains of human cocaine abusers. | Bannon M et al. | β | 2005 | β |
| Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. | Webster MJ et al. | β | 2005 | β |
| Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. | BΓΆnsch D et al. | β | 2005 | β |
| Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's disease. | Katsel PL et al. | β | 2005 | β |
| Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats. | Miguel-Hidalgo JJ | β | 2005 | β |
| Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. | Satoh J et al. | β | 2005 | β |
| Morphine-induced changes of gene expression in the brain. | Ammon-Treiber S et al. | β | 2005 | β |
| Neurocircuitry in alcoholism: a substrate of disruption and repair. | Sullivan EV et al. | β | 2005 | β |
| Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. | Blednov YA et al. | β | 2005 | β |
| Revealing alcohol abuse: to ask or to test? | Alling C et al. | β | 2005 | β |
| The search for candidate genes of alcoholism: evidence from expression profiling studies. | Sommer W et al. | β | 2005 | β |
| Towards unraveling ethanol-specific neuro-metabolomics based on ethanol responsive genes in vivo. | Uddin RK et al. | β | 2005 | β |
| Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. | Aston C et al. | β | 2005 | β |
| Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. | Worst TJ et al. | β | 2005 | β |
| A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism. | Arlinde C et al. | β | 2004 | β |
| A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. | Thiele TE et al. | β | 2004 | β |
| Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice. | Blednov YA et al. | β | 2004 | β |
| Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. | Iwamoto K et al. | β | 2004 | β |
| Diazepam-induced adaptive plasticity revealed by alpha1 GABAA receptor-specific expression profiling. | Huopaniemi L et al. | β | 2004 | β |
| Dopamine and alcoholism: neurobiological basis of ethanol abuse. | Tupala E et al. | β | 2004 | β |
| Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism. | BΓΆnsch D et al. | β | 2004 | β |
| Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence. | Heilig M et al. | β | 2004 | β |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | β | 2004 | β |
| Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. | Albertson DN et al. | β | 2004 | β |
| Gene expression profiling: from microarrays to medicine. | Weeraratna AT et al. | β | 2004 | β |
| Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. | Liu J et al. | β | 2004 | β |
| Genetic study of alcoholism and novel gene expression in the alcoholic brain. | Fan L et al. | β | 2004 | β |
| Microarray analysis of ethanol-treated cortical neurons reveals disruption of genes related to the ubiquitin-proteasome pathway and protein synthesis. | Gutala R et al. | β | 2004 | β |
| Microarray analysis of mouse brain gene expression following acute ethanol treatment. | Treadwell JA et al. | β | 2004 | β |
| Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. | Mobbs CV et al. | β | 2004 | β |
| Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. | Saito M et al. | β | 2004 | β |
| Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. | Davies AG et al. | β | 2004 | β |
| Pharmacogenetic studies of alcohol self-administration and withdrawal. | Crabbe JC et al. | β | 2004 | β |
| The application of proteomics to the human alcoholic brain. | Lewohl JM et al. | β | 2004 | β |
| Alcoholism and obesity: overlapping neuropeptide pathways? | Thiele TE et al. | β | 2003 | β |
| alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. | Liang T et al. | β | 2003 | β |
| A role for neuropeptide Y in alcohol intake control: evidence from human and animal research. | Thiele TE et al. | β | 2003 | β |
| Biochemical and molecular studies using human autopsy brain tissue. | Hynd MR et al. | β | 2003 | β |
| Candidate genes for alcohol dependence: animal studies. | Schumann G et al. | β | 2003 | β |
| DNA microarrays: translation of the genome from laboratory to clinic. | Geschwind DH | β | 2003 | β |
| Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference. | Hoffman PL et al. | β | 2003 | β |
| Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP. | Kenchappa RS et al. | β | 2003 | β |
| Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. | Hof PR et al. | β | 2003 | β |
| Methods for the identification of differentially expressed genes in human post-mortem brain. | Mayfield RD et al. | β | 2003 | β |
| Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. | Pandey SC et al. | β | 2003 | β |
| Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. | Tkachev D et al. | β | 2003 | β |
| Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. | Lehrmann E et al. | β | 2003 | β |
| Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. | Sokolov BP et al. | β | 2003 | β |
| Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. | Raghavendra Rao VL et al. | β | 2002 | β |