Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse.
paper
Cited
Public
Unavailable
- Authors
- Lehrmann, E; Oyler, J; Vawter, M P; Hyde, T M; Kolachana, B; Kleinman, J E; Huestis, M A; Becker, K G; Freed, W J
- Year
- 2003
- Journal
- The pharmacogenomics journal
- PMID
- 12629581
- DOI
- 10.1038/sj.tpj.6500146
- PMCID
- PMC1907635
CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine abusers and controls. The presence of cocaine and related metabolites was confirmed by gas chromatography-mass spectrometry. Sixty-five transcripts were differentially expressed, indicating alterations in energy metabolism, mitochondria and oligodendrocyte function, cytoskeleton and related signaling, and neuronal plasticity. There was evidence for two distinct states of transcriptional regulation, with increases in gene expression predominating in subjects testing positive for a metabolite indicative of recent 'crack' cocaine abuse and decreased expression profiles in the remaining cocaine subjects. This pattern was confirmed by quantitative polymerase chain reaction for select transcripts. These data suggest that cocaine abuse targets a distinct subset of genes in the dlPFC, resulting in either a state of acute activation in which increased gene expression predominates, or a relatively destimulated, refractory phase.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking. | Barry SM et al. | β | 2026 | β |
| Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression. | Orr E et al. | β | 2026 | β |
| Melanin-Concentrating Hormone (MCH): Role in Mediating Reward-Motivated and Emotional Behavior and the Behavioral Disturbances Produced by Repeated Exposure to Reward Substances. | Karatayev O et al. | β | 2025 | β |
| Variation of Myelin-associated Gene Expression and <i>Ndrg1</i> within the Prefrontal Cortex as Determinants for Initial Level of Response to Alcohol | Wolstenholme JT et al. | β | 2025 | β |
| Cocaine perturbs mitovesicle biology in the brain. | D'Acunzo P et al. | β | 2023 | β |
| Molecular genetics of cocaine use disorders in humans. | FernΓ ndez-Castillo N et al. | β | 2022 | β |
| Association of the Uncoupling Protein 2-866 G/A Polymorphism with Family History and Duration of Tobacco Use Disorder in a Turkish Population. | Mervan Aytac H et al. | β | 2021 | β |
| Partial connectomes of labeled dopaminergic circuits reveal non-synaptic communication and axonal remodeling after exposure to cocaine. | Wildenberg G et al. | β | 2021 | β |
| The role of mitochondria in cocaine addiction. | Thornton C et al. | β | 2021 | β |
| Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction. | Huggett SB et al. | β | 2020 | β |
| Network preservation reveals shared and unique biological processes associated with chronic alcohol abuse in NAc and PFC. | Vornholt E et al. | β | 2020 | β |
| Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction. | Bhattacherjee A et al. | β | 2019 | β |
| Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents. | Camilo C et al. | β | 2019 | β |
| HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders. | Cotto B et al. | β | 2019 | β |
| HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure. | Shao X et al. | β | 2019 | β |
| Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research. | Hampton WH et al. | β | 2019 | β |
| Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. | Chandra R et al. | β | 2017 | β |
| Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder. | Ribeiro EA et al. | β | 2017 | β |
| The Alterations in Mitochondrial DNA Copy Number and Nuclear-Encoded Mitochondrial Genes in Rat Brain Structures after Cocaine Self-Administration. | Sadakierska-Chudy A et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| Cocaine and mitochondria-related signaling in the brain: A mechanistic view and future directions. | de Oliveira MR et al. | β | 2016 | β |
| Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways. | Krasnova IN et al. | β | 2016 | β |
| Gene expression in the addicted brain. | Zhou Z et al. | β | 2014 | β |
| Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity? | Niciu MJ et al. | β | 2014 | β |
| Psychostimulants and brain dysfunction: a review of the relevant neurotoxic effects. | GonΓ§alves J et al. | β | 2014 | β |
| Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration. | Smith HR et al. | β | 2014 | β |
| Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria. | Cunha-Oliveira T et al. | β | 2013 | β |
| Cortical-striatal gene expression in neonatal hippocampal lesion (NVHL)-amplified cocaine sensitization. | Chambers RA et al. | β | 2013 | β |
| Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome. | Eipper-Mains JE et al. | β | 2013 | β |
| Influence of the dopaminergic system, CREB, and transcription factor-ΞΊB on cocaine neurotoxicity. | Planeta CS et al. | β | 2013 | β |
| Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria. | Cunha-Oliveira T et al. | β | 2013 | β |
| Nuclear calcium signalling in the regulation of brain function. | Bading H | β | 2013 | β |
| Potential translational targets revealed by linking mouse grooming behavioral phenotypes to gene expression using public databases. | Roth A et al. | β | 2013 | β |
| The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma. | Pei X et al. | β | 2013 | β |
| Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine. | Romanova EV et al. | β | 2012 | β |
| Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. | Eipper-Mains JE et al. | β | 2012 | β |
| Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. | Padgett CL et al. | β | 2012 | β |
| Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. | Romanova EV et al. | β | 2010 | β |
| Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. | Kristiansen LV et al. | β | 2009 | β |
| Simultaneous quantification of nicotine, opioids, cocaine, and metabolites in human fetal postmortem brain by liquid chromatography tandem mass spectrometry. | Shakleya DM et al. | β | 2009 | β |
| Target identification for CNS diseases by transcriptional profiling. | Altar CA et al. | β | 2009 | β |
| Correlating human and animal studies of cocaine abuse and gene expression. | Lull ME et al. | β | 2008 | β |
| Transcriptional correlates of human substance use. | Lehrmann E et al. | β | 2008 | β |
| CNS proteomes in alcohol and drug abuse and dependence. | Matsumoto I et al. | β | 2007 | β |
| Cytosolic proteomic alterations in the nucleus accumbens of cocaine overdose victims. | Tannu N et al. | β | 2007 | β |
| Diffusion tensor imaging eigenvalues: preliminary evidence for altered myelin in cocaine dependence. | Moeller FG et al. | β | 2007 | β |
| Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. | Mash DC et al. | β | 2007 | β |
| Rnd family genes are differentially regulated by 3,4-methylenedioxymethamphetamine and cocaine acute treatment in mice brain. | Marie-Claire C et al. | β | 2007 | β |
| Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. | Marchionini DM et al. | β | 2007 | β |
| The future of plant drug discovery. | Littleton J | β | 2007 | β |
| A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brain. | Lowe RH et al. | β | 2006 | β |
| Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. | Albertson DN et al. | β | 2006 | β |
| Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. | Cunha-Oliveira T et al. | β | 2006 | β |
| Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. | Lehrmann E et al. | β | 2006 | β |
| Gene expression profiling in the brains of human cocaine abusers. | Bannon M et al. | β | 2005 | β |
| Microarray studies of psychostimulant-induced changes in gene expression. | Yuferov V et al. | β | 2005 | β |
| Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia. | Vawter MP et al. | β | 2004 | β |
| Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. | Albertson DN et al. | β | 2004 | β |