Transcripts of 26 of the 35 selected candidate genes map as cis-QTLs (LOD≥3) in the BXD CNS datasets (table 3). These putatively cis-regulated genes are among the strongest candidates in the QTL interval. The D allele in Qrr1 has the positive effect on the expression of Sdhc, Ndufs2, Adamts4, Dedd, Pfdn2, Ltap, Pea15, Atp1a2, Kcnj9, Kcnj10, Igsf4b, and Grem2. Increase in expression caused by the D allele ranges from about 10% for Adamts4 to over 2-fold for Atp1a2. In contrast, the B allele has the positive effect on the expression of Pcp4l1, Fcer1g, B4galt3, Ppox, Ufc1, Nit1, Usf1, Copa, Pex19, Wdr42a, Igsf8, Dfy, Fmn2, and Rgs7. Increase in expression caused by the B allele ranges from about 7% for Usf1 to 40% for Pex19.
