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Chunk #15 — Results — Candidates in Qrr1

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Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression.
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B6 but not in D2. The expression difference is robust enough to generate cis-QTLs with very high LOD scores (>40). This gene cluster has low expression in the CNS (Affymetrix declares this probe sets to be “not present”), but high expression in tissues such as hematopoietic stem cells and kidney, in which the trans-effect of Qrr1 is not detected. The Ifi200 gene cluster was therefore excluded as a high priority candidate.