of hypotheses for functional validation experiments. For example, if a gene is prioritized because of an associated loss-of-function SNP, follow-up validation experiments focusing on a knock-out of this gene may provide disease relevant functional information. On the other hand, if a gene is prioritized because a risk associated allele of a SNP increases expression of this gene in brain, then an overexpression experiment of this gene in neuronal cell cultures would be a more relevant experiment.
