UV analyses were performed as described under ‘TATES’. Resulting p-values were extracted for the purpose of this study. UV-MA was performed with METAL [24] (http://www.sph.umich.edu/csg/abecasis/Metal/), using univariate results per trait as input files and the analysis scheme ‘scheme samplesize’, which uses p-value and direction of effect as input for the MA and weighs according to sample size. PCA was performed in R using the princomp command. UV-PCA was executed using the first principal component (PC) in a univariate analysis as described above.
