CDH2 (N-cadherin), ESR1, KDR (VEGFR2), MYC, SMAD3, STAT5A, and a variant of STAT3 phosphorylated at Tyr705 (STAT3_pY705). Next, we matched 9 relevant ssGSEA hallmark profiles to those phenotypes using the IC, and assessed the significance of their matching scores using an empirical permutation test as above (2,083,333 permutations). Figure 3 (A through I) shows the results. We observe that all the relevant hallmark enrichment profiles display a high degree of association against the corresponding protein profiles (IC scores and p-values):
