The Molecular Signatures Database (MSigDB) hallmark gene set collection.
paper
Cited
Public
- Authors
- Liberzon, Arthur; Birger, Chet; ThorvaldsdΓ³ttir, Helga; Ghandi, Mahmoud; Mesirov, Jill P; Tamayo, Pablo
- Year
- 2015
- Journal
- Cell systems
- PMID
- 26771021
- DOI
- 10.1016/j.cels.2015.12.004
- PMCID
- PMC4707969
The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis. Since its creation, MSigDB has grown beyond its roots in metabolic disease and cancer to include >10,000 gene sets. These better represent a wider range of biological processes and diseases, but the utility of the database is reduced by increased redundancy across, and heterogeneity within, gene sets. To address this challenge, here we use a combination of automated approaches and expert curation to develop a collection of "hallmark" gene sets as part of MSigDB. Each hallmark in this collection consists of a "refined" gene set, derived from multiple "founder" sets, that conveys a specific biological state or process and displays coherent expression. The hallmarks effectively summarize most of the relevant information of the original founder sets and, by reducing both variation and redundancy, provide more refined and concise inputs for gene set enrichment analysis.
Analysis of Hedgehog signaling in medulloblastoma. The figure shows ssGSEA scores ranked by their degree of association (IC) between the Hedgehog and photoreceptor phenotype for: A) the 50 hallmarks and, B) the Hedgehog hallmark and 9 of its top scoring founder gene sets. The IC scores, p-values and FDRβs appear on the right side of the heat maps. Black and grey colors denote medulloblastoma subtypes (Hedgehog and photoreceptor subtypes respectively).
Ranks of gene sets grouped by biological themes. The horizontal axis denotes rankings of gene sets enriched in the GBM data with respect to necrosis. The biological themes are on the right side of the graph. The vertical bars indicate ranks of gene sets. Black bars denote the 245 significantly enriched sets. Gray bars stand for the gene sets that were not enriched significantly. The uncategorized gene sets are not shown. The rows indicate 11 biological themes. The red box shows gene sets that are pushed down the list by high scoring gene sets representing hypoxia/glycolysis, EMT, and NFkB signaling.
Matching hallmark enrichment scores to phenotypes defined by protein levels. The top row of the heat maps shows Reverse Phase Protein Array (RPPA) profiles of selected proteins sorted in descending order from left to right. The chosen protein expression profiles are from top to bottom: A) MYC (c-Myc-R-C), B) ESR1 (ER-alpha-R-V), C) AR (AR-R-V), D) BCL2 (Bcl-2-M-V), E) CDH2 (N-cadherin-R-V), F) SMAD3 (Smad3-R-V), G) STAT3 pY705 (STAT3_pY705-R-V), H) STAT5A (STAT5-alpha-R-V) and I) KDR scores.
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| Glutamine metabolism tunes myeloid responses to drive resolution of inflammation during skin repair. | Xu Y et al. | β | 2026 | β |
| GRAFT: a graph-aware fusion transformer for cancer driver gene prediction. | Cho SP et al. | β | 2026 | β |
| GZMK<sup>+</sup>CD8<sup>+</sup> T cells target a specific acinar cell type in SjΓΆgren's disease. | Pranzatelli TJF et al. | β | 2026 | β |
| Harnessing AI to fuse phenotypic signatures for drug target identification: progress in computational modeling. | Chen F et al. | β | 2026 | β |
| Harnessing transcriptomics for discovery of natural products to overcome acquired cancer resistance. | Yeo H et al. | β | 2026 | β |
| Harnessing Ξ³Ξ΄ T cells for B7-H3-targeting CAR therapy to enhance anti-tumor therapy in glioblastoma. | Wu H et al. | β | 2026 | β |
| HDAC1 has intrinsic protease activity and regulates transcription through clipping histone H3 N-terminal tail. | Shin Y et al. | β | 2026 | β |
| Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion. | Yajima S et al. | β | 2026 | β |
| Hepatic zonation determines tumorigenic potential of mutant Ξ²-catenin. | Raven A et al. | β | 2026 | β |
| HER2-specific synthetic antigen receptor T cell therapy synergizes with radiotherapy to provide improved antitumor efficacy in non-small cell lung cancer. | Biziotis OD et al. | β | 2026 | β |
| Heterogeneity and plasticity of the naive CD4<sup>+</sup> T cell compartment. | Sajani A et al. | β | 2026 | β |
| HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma. | Naas S et al. | β | 2026 | β |
| High CDCP1 Expression Reflects Immune and Stromal Remodeling and Oncogenic Signaling in Pancreatic Ductal Adenocarcinoma. | Miyake K et al. | β | 2026 | β |
| High PARP7 Expression is Associated with Higher Estrogen Response and Immune Suppression but Less Cell Proliferation and Better Survival in Breast Cancer. | Rodriguez L et al. | β | 2026 | β |
| Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches. | Alouche N et al. | β | 2026 | β |
| Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer. | Davies HR et al. | β | 2026 | β |
| Hormonal regulation of cochlear gene expression: effects of the estrous cycle, ovariectomy, and estradiol treatment. | Zhang C et al. | β | 2026 | β |
| HOXC6 overexpression stimulates cell migration and correlates with poor prognosis in head and neck squamous cell carcinoma. | Choudhury SR et al. | β | 2026 | β |
| HSFSurv: A hybrid supervision framework at individual and feature levels for multimodal cancer survival analysis. | Fu B et al. | β | 2026 | β |
| HumanBase: an interactive AI platform for human biology. | Sealfon RSG et al. | β | 2026 | β |
| Hydrogen sulfide rescues IFNΞ³/TNFΞ±-induced intestinal epithelial barrier dysfunction by enhancing oxidative phosphorylation. | de Oliveira JP et al. | β | 2026 | β |
| Hypoxia-Induced Fibroblast IL-6 Promotes Immunosuppressive Macrophage Phenotypes in Pancreatic Cancer. | Hannifin S et al. | β | 2026 | β |
| Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition. | Nair V et al. | β | 2026 | β |
| Identification and characterization of a TGF-Ξ²-independent SMAD4-NFATc1-STAT3 regulatory axis. | Ouyang W et al. | β | 2026 | β |
| Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis. | Lu Y et al. | β | 2026 | β |
| Identification and validation of PANoptosis-related genes in Alzheimer's disease. | Zhou W et al. | β | 2026 | β |
| Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches. | Wang J et al. | β | 2026 | β |
| Identification of biomarkers associated with endoplasmic reticulum stress-related cell death in osteoporosis based on bulk and single-cell transcriptomic analyses and experimental validation. | Xia Y et al. | β | 2026 | β |
| Identification of molecularly targeted therapy-induced immunopeptidome in diffuse midline glioma (DMG). | Khairkhah N et al. | β | 2026 | β |
| Identification of necrosis-related signature for predicting prognosis and immunotherapy response in gastric cancer. | Zhang Y et al. | β | 2026 | β |
| Identification of the Role of Necroptosis-Related Genes in the Oxidative Damage of Lens Epithelial Cells and Validation in Ultraviolet B-induced Cataract in Rats. | Liang Y et al. | β | 2026 | β |
| Identification of Tumor- and Immunosuppression-Driven Glioblastoma Subtypes Characterized by Clinical Prognosis and Therapeutic Targets. | Zhang P et al. | β | 2026 | β |
| Identifying Crucial Genes Associated with Pyroptosis in Lupus Nephritis. | Shi M et al. | β | 2026 | β |
| IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation. | Park JW et al. | β | 2026 | β |
| iMCN: information compression-based multimodal confidence-guided fusion network for cancer survival prediction. | Lyu C et al. | β | 2026 | β |
| Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling. | Warrick KA et al. | β | 2026 | β |
| Immune dysregulation triggered by inflammatory cytokines in patients with severe respiratory infections. | Li J et al. | β | 2026 | β |
| Immune-microbiome coordination defines interferon setpoints in healthy humans. | Babdor J et al. | β | 2026 | β |
| Impacts of host genetics on gut microbiome composition in Alzheimer's disease. | Liu J et al. | β | 2026 | β |
| Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition. | Arneson-Wissink PC et al. | β | 2026 | β |
| Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis. | Chiche A et al. | β | 2026 | β |
| Inhibiting stearoyl-CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response. | Wilson A et al. | β | 2026 | β |
| Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine. | Wu S et al. | β | 2026 | β |
| Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy. | Talla A et al. | β | 2026 | β |
| In silico temporal mapping of fibrogenic and immune gene dynamics in rat lung following crystalline silica exposure. | Lei P et al. | β | 2026 | β |
| In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment. | Lyubetskaya A et al. | β | 2026 | β |
| Insulin signaling engages divergent transcriptional mechanisms in neural and metabolic tissues. | Jain R et al. | β | 2026 | β |
| Integrated analysis of spatial and single-cell profiles reveals cell type-specific regulation of synaptic plasticity in human brain aging. | Guan J et al. | β | 2026 | β |
| Integrated multi-omics analyses identified the H3K18la-based spatiotemporal characteristics and risk-stratified treatment strategy in lung adenocarcinoma. | Shen A et al. | β | 2026 | β |
| Integrated multi-omics profiling reveals the potential role of maternal systemic immune dysregulation driven by monocyte/macrophage in preeclampsia. | Yuan X et al. | β | 2026 | β |
| Integrated single-cell and transcriptomic analysis of CD8<sup>+</sup>CD101<sup>+</sup>TIM3<sup>+</sup> T cells in hepatocellular carcinoma: implications for tumor microenvironment and prognostic modeling. | Ran F et al. | β | 2026 | β |
| Integrating natural and engineered genetic variations to decode regulatory influence on blood traits. | Tardaguila M et al. | β | 2026 | β |
| Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma. | Chen J et al. | β | 2026 | β |
| Integration of human and mouse single-cell transcriptomes of the developing cerebellum nominates cells-of-origin for group 3 and 4 medulloblastoma. | Cheong I et al. | β | 2026 | β |
| Integration of multiomic and multi-phenotypic data identifies biological pathways associated with physical fitness. | Alizadeh A et al. | β | 2026 | β |
| Integration of multi-omics and machine learning to reveal the anti-osteoporosis effects of Hederagenin by inhibiting lipid peroxidation via the GPX4/p-STAT1/PTGS2 axis. | Lu J et al. | β | 2026 | β |
| Integration of single-cell and bulk transcriptomics with machine learning identifies LDHA as a lactate-related diagnostic and prognostic biomarker in sepsis. | Lin Z et al. | β | 2026 | β |
| Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2. | YekedΓΌz E et al. | β | 2026 | β |
| Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer. | Fu Z et al. | β | 2026 | β |
| Integrative Single-Cell and Machine Learning Analysis Identifies a Nucleotide Metabolism-Related Signature Predicting Prognosis and Immunotherapy Response in LUAD. | Zhao S et al. | β | 2026 | β |
| Integrative transcriptomic and machine learning analysis identifies PYCARD and IFI30 as immune-lysosomal biomarkers of ANCA-associated glomerulonephritis. | Bei L et al. | β | 2026 | β |
| Interferon-Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple-Negative Breast Cancer. | Zhang Z et al. | β | 2026 | β |
| Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression. | PeirΓ³-Moreno C et al. | β | 2026 | β |
| Interplay between AIB1 genotypes and radiotherapy in a Swedish population-based breast cancer cohort. | Wiberg A et al. | β | 2026 | β |
| Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic Regression. | Yang L et al. | β | 2026 | β |
| Interpretable Cancer Survival Prediction by Fusing Semantic Labelling of Cell Types and Whole Slide Images. | Chen J et al. | β | 2026 | β |
| Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton. | Rezola Artero M et al. | β | 2026 | β |
| Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma. | Silver NL et al. | β | 2026 | β |
| Investigating the Molecular Mechanisms of the Anticancer Effects of Eugenol and Cinnamaldehyde Against Colorectal Cancer (CRC) Cells In Vitro. | Bernacchi A et al. | β | 2026 | β |
| Investigating the oncogenic role of aberrant EZH2 in hepatoblastoma. | Glaser K et al. | β | 2026 | β |
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| IRDRM: Exploring Biological Traits and Clinical Significance in Breast Cancer Through Gene Pairs and Somatic Mutation Profiles. | Su D et al. | β | 2026 | β |
| ITLN1, orchestrated by the IFNΞ³-IRF1 axis, suppresses hepatocellular carcinoma proliferation via ERK1/2 activation. | Yuan T et al. | β | 2026 | β |
| JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms. | Kealy D et al. | β | 2026 | β |
| Key mitochondria-related genes and molecular mechanisms shared between polycystic ovary syndrome and atherosclerosis: A bioinformatics and machine learning study. | Tang L et al. | β | 2026 | β |
| KLRG1 defines a distinct tumor-infiltrating granzyme K+ CD8β+βT cell population. | Thomas J et al. | β | 2026 | β |
| Kojic acid inhibits melanoma progression by targeting the MYC-CCNA2/KPNA2 axis. | Chen Y et al. | β | 2026 | β |
| Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice. | Bergo V et al. | β | 2026 | β |
| Lactylation-related gene signature for prognosis prediction and immune infiltration assessment in lung adenocarcinoma via bulk and single-cell RNA sequencing. | Zhou H et al. | β | 2026 | β |
| Leveraging untargeted metabolomics in combination with machine learning to uncover novel insights into bladder cancer. | Kamal AHM et al. | β | 2026 | β |
| LMO2 Regulates Epithelial-Mesenchymal Plasticity of Mammary Epithelial Cells. | Acosta VH et al. | β | 2026 | β |
| Longitudinal DCE MRI Vascular Textures: Radiologic and Biologic Insights for pCR Prediction in HER2-Negative Breast Cancer. | Teng X et al. | β | 2026 | β |
| Loss of Aquaporin-1 in Tumor Cells Fosters Intrahepatic Cholangiocarcinoma Progression. | Gaspari CI et al. | β | 2026 | β |
| Loss of Ezh2 precipitates lethal disease progression in a mouse model of Calr-mutated myeloproliferative neoplasms. | Ueda K et al. | β | 2026 | β |
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| Low, non-psychedelic doses of psilocybin as a novel treatment for MASLD, obesity and type 2 diabetes via 5-HT2B receptor-dependent mechanisms. | Colognesi M et al. | β | 2026 | β |
| <i>BCL2A1</i><sup>high</sup> CD8<sup>+</sup> T Cells Are a Survival-Associated Predictor of Immune Checkpoint Blockade Response in Lung Adenocarcinoma. | Pham HMQ et al. | β | 2026 | β |
| <i>DEprot</i>: a comprehensive R-package for the analysis of label-free quantitation mass spectrometry data. | Eickhoff N et al. | β | 2026 | β |
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| M2 macrophages modulate the differentiation of CD8β+βCD101-TIM3β+βT cells via the SPP1βCD44 pathway, influencing the immunotherapeutic response in NSCLC. | Zhang G et al. | β | 2026 | β |
| Machine learning based prioritisation of genes associated with osteoarthritis joint damage in animals. | Soul J et al. | β | 2026 | β |
| Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD. | Wu S et al. | β | 2026 | β |
| Machine learning identifies glycosphingolipid signature linking immune dysregulation and clinical prognosis in uveal melanoma. | Guo H et al. | β | 2026 | β |
| Machine learning model on multi-omics data enables risk stratification and identifies molecular heterogeneity and therapeutic targets in glioblastoma. | Zhang Z et al. | β | 2026 | β |
| Magrolimab (Hu5F9-G4) promotes macrophage M1 polarization and is associated with enhanced autophagy in colorectal cancer. | Lin WR et al. | β | 2026 | β |
| Mapping convergent regulators of melanoma drug resistance by PerturbFate. | Xu Z et al. | β | 2026 | β |
| Mapping the Hypoxic Fitness Landscape of Retinal Pigment Epithelial Cells. | Calbay O et al. | β | 2026 | β |
| Meis1 Negatively Regulates Epithelial-Mesenchymal Transition via Wnt/Ξ²-catenin Pathway in Oral Submucous Fibrosis. | Cai J et al. | β | 2026 | β |
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| MetaScreener: a robust dual-mode framework for directional prioritization of actionable signatures through multi-dataset and multi-approach integration. | Zhao D et al. | β | 2026 | β |
| Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis. | Khan F et al. | β | 2026 | β |
| Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics. | Struyf N et al. | β | 2026 | β |
| miR-145-5p/CAMSAP2 axis modulates cisplatin sensitivity in non-small cell lung cancer. | Singharajkomron N et al. | β | 2026 | β |
| MIRROR: Multi-Modal Pathological Self-Supervised Representation Learning via Modality Alignment and Retention. | Wang T et al. | β | 2026 | β |
| Mitigating psychological stress-induced cardiac injury: The impact of CB2R agonists on endoplasmic reticulum stress and mitophagy. | Ma C et al. | β | 2026 | β |
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| Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma. | Suresh V et al. | β | 2026 | β |
| Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex. | Risgaard RD et al. | β | 2026 | β |
| Molecular and Clinical Analyses of Gene Fusions Identify Therapeutic Targets in Paired Primary and Metastatic Breast Cancer from the AURORA Program (BIG 14-01). | Biagioni C et al. | β | 2026 | β |
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| Polygenic Contribution to Sensorineural Hearing Loss Implicates Novel Risk Loci and Convergence with Congenital Hearing Loss Genes. | Clifford RE et al. | β | 2026 | β |
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| PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma. | Shen D et al. | β | 2026 | β |
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| Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials. | Wang Z et al. | β | 2026 | β |
| Prediction Analysis of Microarray of 50 genes (PAM50) classifier validated for predicting prostate cancer progression in active surveillance: Miami Active Surveillance Trial (MAST). | Malpani A et al. | β | 2026 | β |
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| Preliminary Study on GZMA- and GSDMB-Associated Pyroptosis and CD8+ T Cell-Mediated Immune Evasion in Skin Cutaneous Melanoma. | Chen J et al. | β | 2026 | β |
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| Probing the Feasibility of Single-Cell Fixed RNA Sequencing from FFPE Tissue. | Liu X et al. | β | 2026 | β |
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| Prospective Breast Cancer Biomarkers Identified Using miR-526b-Driven Metabolic Alterations. | Nault B et al. | β | 2026 | β |
| Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning. | Heller EM et al. | β | 2026 | β |
| Proteomic footprint of serum urate concentration and urate transporter <i>ABCG2</i> dysfunctional polymorphism: a cross-sectional study. | Ohashi Y et al. | β | 2026 | β |
| Proteomic remodeling during tumor cell-induced platelet aggregation unveils metastatic drivers in colorectal cancer. | Sauer T et al. | β | 2026 | β |
| pTΞ± enhances mRNA translation and potentiates CAR T cells for solid tumor eradication. | Shi Y et al. | β | 2026 | β |
| Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization. | Edelstein SE et al. | β | 2026 | β |
| Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy-Treated Melanoma. | Wilski-Cronin NA et al. | β | 2026 | β |
| Recapitulating patient-to-patient colorectal cancer tumor heterogeneity using patient-derived xenograft cells in an engineered tissue model. | Hassani I et al. | β | 2026 | β |
| Region-specific proteomic profiling of brain interstitial fluid <i>via</i> a micro-invasive sampling platform. | Cao Q et al. | β | 2026 | β |
| Regulation and reversal of paclitaxel resistance via the STAT1βmediated apoptotic pathway in ovarian cancer. | Wang F et al. | β | 2026 | β |
| Regulation of Lipid Biology-Associated Gene Expression in Granulosa Cells in Hyperandrogenic PCOS: A Possible Link Between Dyslipidemia and Hyperandrogenism. | Berkel C | β | 2026 | β |
| Repositioning Antihistamine for Cancer Therapy: Clemizole as a Template for the Design of Liver Tissue-Targeting Epigenetic-Modifying Agents. | Walunj DT et al. | β | 2026 | β |
| Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment. | Zhang Y et al. | β | 2026 | β |
| R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers. | Zhang C et al. | β | 2026 | β |
| Robust and efficient annotation of cell states through gene signature scoring. | Ciernik L et al. | β | 2026 | β |
| Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma. | Lin Y et al. | β | 2026 | β |
| Role of POLE2/GINS1-mediated AKT/mTOR pathway in RCC autophagy, proliferation, and metastasis: evidences from bioinformatic, clinical, and experimental data. | Su Y et al. | β | 2026 | β |
| Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis. | Lilly AC et al. | β | 2026 | β |
| scCT-DB, an omnibus for cancer patient-derived paired pre- and post-treatment single-cell transcriptomes to reveal drug perturbation and drug resistance mechanisms. | Ma S et al. | β | 2026 | β |
| scGeneBank: cross-species screening of functional gene sets at single-cell resolution. | Qin S et al. | β | 2026 | β |
| scSuperAnnotator: a platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data. | Qi Q et al. | β | 2026 | β |
| SenSet defines cell-type specific senescence signatures in the aged human lung. | Hasanaj E et al. | β | 2026 | β |
| Serglycin modulates inflammation and metabolism in macrophages. | Porteymour S et al. | β | 2026 | β |
| SETD7 methylates the endometrial master regulator HOXA10 to facilitate H3K4me1 peaking for endometrial decidualization. | Chen Q et al. | β | 2026 | β |
| Sex specific genomic insights into type 1 diabetes through GWAS and single cell transcriptome analysis. | Qu HQ et al. | β | 2026 | β |
| Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci. | Hope S et al. | β | 2026 | β |
| Simultaneous In-Depth Single-Cell Proteomic and Metabolomic Analysis. | Wu J et al. | β | 2026 | β |
| Single-cell analysis reveals cytotoxic and memory CD8<sup>+</sup> T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation. | Li H et al. | β | 2026 | β |
| Single-cell and multi-omic characterization of ex vivo expanded ASTRLs from stable kidney transplant recipients reveals a regulatory T cell phenotype. | Tripathi S et al. | β | 2026 | β |
| Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer. | Li H et al. | β | 2026 | β |
| Single-cell epigenetic landscape, microenvironment interactions, and gene regulatory modules of non-functioning pituitary adenomas. | Zhang Z et al. | β | 2026 | β |
| Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression. | Wahnschaffe L et al. | β | 2026 | β |
| Single-cell immune atlas of mouse testes unveils metabolic reprogramming of FOLR2β+βmacrophages in orchestrating testicular immunity during aging. | Li X et al. | β | 2026 | β |
| Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer. | Marteau V et al. | β | 2026 | β |
| Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC. | Galvani RGA et al. | β | 2026 | β |
| Single-cell profiling reveals lineage-specific fibroblast stromal subtypes drive ECM remodeling and immune modulation in the hepatocellular carcinoma tumor microenvironment. | Jiang Z et al. | β | 2026 | β |
| Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis. | Duffy FJ et al. | β | 2026 | β |
| Single-cell RNAseq identifies persistent epithelial and immune dysfunction in PwCF by mitigating inter-individual sampling heterogeneity. | Cybulski T et al. | β | 2026 | β |
| Single-cell spatial transcriptomics uncovers niches that govern response to PD-1/PD-L1 blockade in cutaneous squamous cell carcinoma. | Lee MY et al. | β | 2026 | β |
| Single-cell transcriptome profiling of post-treatment and treatment-naΓ―ve colorectal cancer: Insights into putative mechanisms of chemoresistance. | Puzanov GA et al. | β | 2026 | β |
| Single-cell transcriptomics of bronchoalveolar lavage reveals divergent macrophage subpopulations and trajectories in interstitial lung disease. | Zhang LY et al. | β | 2026 | β |
| Single-Nuclei Resolution of Intermuscular Adipose Tissue Indicates an Inflammation-Associated Cellular Profile in Individuals With Knee Osteoarthritis: Findings From the SOMMA KOA Ancillary Study. | Elingaard-Larsen LO et al. | β | 2026 | β |
| Single-Nucleus Multi-Omics Reveals Hypoxia-Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma. | You C et al. | β | 2026 | β |
| Single-nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC). | Zhu J et al. | β | 2026 | β |
| Single-nucleus RNA sequencing reveals the underlying roadmap of early gonadal differentiation in teleost. | Wang J et al. | β | 2026 | β |
| Single-nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity. | Hack K et al. | β | 2026 | β |
| Single-patient single-cell RNA sequencing reveals neuroendocrine predominance and immunosuppression in small-cell lung cancer. | Wang Y et al. | β | 2026 | β |
| SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling. | Hamaidi I et al. | β | 2026 | β |
| SjΓΆgren's patient subgroups identified through whole genome DNA methylation profiling. | Solomon O et al. | β | 2026 | β |
| Somatic mutations distinguish melanocyte subpopulations in human skin. | Tandukar B et al. | β | 2026 | β |
| SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice. | Luo C et al. | β | 2026 | β |
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| Sp1 mechanotransduction regulates breast cancer cell invasion in engineered viscoelastic extracellular matrices. | Sharma A et al. | β | 2026 | β |
| Spatial Analysis of Intraductal Papillary Mucinous Neoplasms Defines a Paradoxical Keratin 17-Positive, Low-Grade Epithelial Population Harboring Malignant Features. | Li J et al. | β | 2026 | β |
| Spatial and multi-omics transcriptomic dissects platinum resistance in lung adenocarcinoma: a five-gene predictive model with tumor microenvironment dynamics. | Chen J et al. | β | 2026 | β |
| Spatially-guided metabolomics profiling of metabolic regions in human tumor tissues. | Lee JJ et al. | β | 2026 | β |
| Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus. | Mulvey B et al. | β | 2026 | β |
| Spatially resolved osteoblast-traced transcriptomics uncovers TGF-Ξ² as a combination target with sclerostin in osteoporosis. | Choi A et al. | β | 2026 | β |
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| Spatially resolved transcriptomics identifies tumor-stroma-immune networks and therapeutic targets in endocrine-resistant advanced breast cancer treated with Everolimus+Letrozole: insights from the MIRACLE trial. | Xue X et al. | β | 2026 | β |
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| Spatial Molecular Plasticity Underpins Lethal Morphologies in Lung Adenocarcinoma. | Williams HL et al. | β | 2026 | β |
| Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors. | Tu C et al. | β | 2026 | β |
| Spatial transcriptomics reveals a molecular tumor budding signature in head and neck cancer. | Ourailidis I et al. | β | 2026 | β |
| Spatiotemporal cellular map of the developing human reproductive tract. | Lorenzi V et al. | β | 2026 | β |
| Spatiotemporal dynamics of ecto-5'-nucleotidase (CD73) in mouse retina under physiological conditions. | Ishii R et al. | β | 2026 | β |
| Spatiotemporal profiling of endocytic regulators in the immunosuppressive TAM microenvironment of glioma. | Hua S et al. | β | 2026 | β |
| Spatiotemporal transcriptomic mapping reveals region-specific glial activation and astrocyte shifts in epileptogenesis beyond the hippocampus. | Dufour A et al. | β | 2026 | β |
| Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways. | Dupas SJ et al. | β | 2026 | β |
| SPT6 maintains epidermal homeostasis by inhibiting an NF-ΞΊB-positive feedback loop to prevent excessive inflammation. | Sun Y et al. | β | 2026 | β |
| Structural dynamics of microtubules in glioma: impact on macrophage M2 polarization and tumor cell heterogeneity. | Liu X et al. | β | 2026 | β |
| Surface Avidity of Anionic Polypeptide Coatings on Layer-by-Layer Nanoparticles Target Cancer-Associated Amino Acid Transporters. | Pires IS et al. | β | 2026 | β |
| Sustained Transcriptional Response to Lipopolysaccharide and Interleukin-4 in an Immortalized Mouse Microglial Cell Line. | Herrero-GonzΓ‘lez A et al. | β | 2026 | β |
| Systemic Proteome Profiling to Differentiate Primary Glomerular Diseases. | Oh JI et al. | β | 2026 | β |
| Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients. | Adri AS et al. | β | 2026 | β |
| SYT8 Drives Colorectal Cancer Progression and Immune Evasion via the SETD1A-H3K4me3 Axis. | Wei J et al. | β | 2026 | β |
| Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors. | Stern YE et al. | β | 2026 | β |
| Targeting muscle wasting: Bioinformatics-derived ubiquitination genes as potential therapeutic targets for sarcopenia. | Liu X et al. | β | 2026 | β |
| Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC. | Chakraborty S et al. | β | 2026 | β |
| Targeting PLK1 Reduces MMP10 to Enhance Radiosensitivity in HPV- Head and Neck Cancer. | Korns J et al. | β | 2026 | β |
| Targeting the ERΞ± DBD-LBD Interface with Mitoxantrone Disrupts Receptor Function through Proteasomal Degradation. | Wang H et al. | β | 2026 | β |
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| T-Cell Receptor and Immune Gene Expression Pharmacodynamics for Durvalumab Alone and with Tremelimumab or Bevacizumab in Unresectable Hepatocellular Carcinoma. | Kelley RK et al. | β | 2026 | β |
| Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC. | Greenwald NF et al. | β | 2026 | β |
| Temporal single-cell landscape suggests infection-induced IgM plasma cells as a correlate of durable influenza immunity. | Li X et al. | β | 2026 | β |
| TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution. | Meng X et al. | β | 2026 | β |
| Tetraspanin 7-mediated endothelial migrasomes unveil a novel mechanism of angiogenesis through the PI3K/AKT pathway in diabetic wound healing. | Wang J et al. | β | 2026 | β |
| TGFΞ² induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis. | Wang Z et al. | β | 2026 | β |
| TGFΞ² signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells. | Ali MM et al. | β | 2026 | β |
| The Allogeneic FAP-CAR-IL15 iNKT Therapy MiNK-215 Remodels the Tumor Stroma to Enhance Antitumor Immunity. | Chantzoura E et al. | β | 2026 | β |
| The FN1-targeted delivery of low-molecular-weight heparin to venous clots revolutionizes thrombosis treatment in CVT. | Jiang H et al. | β | 2026 | β |
| The Gb3-synthase A4GALT is an epigenetically regulated driver of tumor invasiveness in gastrointestinal cancer. | Hirsch ND et al. | β | 2026 | β |
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| The Growing Burden of Early-Onset Lung Cancer in Young Women in China: Analysis for the Global Burden of Disease Study 2021. | Song J et al. | β | 2026 | β |
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| The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia. | Dunham N et al. | β | 2026 | β |
| The mechanism of Qingyi decoction in improving intestinal barrier injury in pancreatitis: Network pharmacology analysis, machine-learning models, and molecular docking. | Xu F et al. | β | 2026 | β |
| The natural L370F ERΞ± variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells. | Cipolletti M et al. | β | 2026 | β |
| The oligogenic inheritance test GCOD detects risk genes and their interactions in congenital heart defects. | Pittman M et al. | β | 2026 | β |
| Therapeutic Spp1 silencing in TREM2<sup>+</sup> cardiac macrophages suppresses atrial fibrillation. | Momin N et al. | β | 2026 | β |
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| TNF-Ξ± blockade mitigates immune checkpoint-related nephritis in a humanized mouse model. | Cuenca Narvaez VD et al. | β | 2026 | β |
| TOX drives CD4<sup>+</sup> T<sub>H</sub>1 effector function, antitumor immunity and autoimmune pathology. | Naizir B et al. | β | 2026 | β |
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| Transcriptional signature of induced neurons differentiates virologically suppressed people with HIV from people without HIV. | Ostermann PN et al. | β | 2026 | β |
| Transcriptomic comparative study between canalicular adenoma and HMGA2::WIF1 canalicular-like pleomorphic adenoma. | Alsugair Z et al. | β | 2026 | β |
| Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell's anti-proliferative effect on cancer cells. | Aunan A et al. | β | 2026 | β |
| Transcriptomics and metabolomics analysis reveal cell subpopulations of trophoblast cells associated with preeclampsia. | Zhu X et al. | β | 2026 | β |
| TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism. | Feiten AF et al. | β | 2026 | β |
| TRIM37 Expression is Associated with Immune Suppression Poor Response to Neoadjuvant Chemotherapy and Worse Survival in ER-Positive/HER2-Negative Breast Cancer. | Tsuchida J et al. | β | 2026 | β |
| Trimodulin supports antibacterial defence and restricts inflammation in preclinical pneumonia models. | Nouailles G et al. | β | 2026 | β |
| Tumor and Perirenal Adipose Tissue Radiomic Models for Pathological T-Stage Prediction and Biological Exploration in Clear Cell Renal Cell Carcinoma. | Wang C et al. | β | 2026 | β |
| Tumor suppressor candidate 1 (TUSC1) drives oxidative phosphorylation and tumor cell death in colorectal cancer. | Manhas J et al. | β | 2026 | β |
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| Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer. | Kastinen M et al. | β | 2026 | β |
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| Validation of molecular profiling to preoperatively predict aggressive pathologic features in differentiated thyroid cancer. | Bauzon J et al. | β | 2026 | β |
| Variant-divergent death: Omicron intensifies bystander T-cell apoptosis via GDF15-BCL2L13. | Gao C et al. | β | 2026 | β |
| Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. | Hafner P et al. | β | 2026 | β |
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| YKT6 Promotes Bladder Cancer Progression by Stabilizing Ξ²-catenin Through USP7-Mediated Deubiquitination. | Tu S et al. | β | 2026 | β |
| 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma. | Saarentaus EC et al. | β | 2025 | β |
| 5-hydroxymethylcytosine analysis reveals stable epigenomic changes in tumor tissue that enable cancer detection in cell-free DNA. | Xue Y et al. | β | 2025 | β |
| A 107 Gene Nanostring Assay Effectively Translates the Cancer Genome Atlas, and Tumour Microenvironment Gastric Cancer Molecular Classification to a Patient-Derived Organoid Model. | Skubleny D et al. | β | 2025 | β |
| AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity. | Venkat A et al. | β | 2025 | β |
| A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression. | Sproviero D et al. | β | 2025 | β |
| Abnormal zona pellucida and follicular development in <i>ZP1</i>-mutant macaques. | Meng W et al. | β | 2025 | β |
| Accumulation of Lymphoid Progenitors with Defective B Cell Differentiation and of Putative Natural Killer Progenitors in Aging Human Bone Marrow. | Poisa-Beiro L et al. | β | 2025 | β |
| A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma. | Zhao W et al. | β | 2025 | β |
| Acidic melanoma microenvironment selects for a senescence-like but also migratory-active subpopulation driving metastatic disease. | Chiheb C et al. | β | 2025 | β |
| Acinar-specific loss of activating transcription factor 3 restricts KRAS<sup>G12D</sup> mediated transcriptional changes and PanIN progression. | Martin MB et al. | β | 2025 | β |
| ACO1 OGDH axis drives mitochondrial immune crosstalk in preeclampsia through systems biology enabling dual target therapy. | Wu M et al. | β | 2025 | β |
| A Combined Model Based on Bone Mineral Density for Noninvasive Prediction of Prognosis in Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors: A Multicenter Retrospective Study. | Gong B et al. | β | 2025 | β |
| A computational reference for human genomics analysis in (poly)phenol research. | Treccani M et al. | β | 2025 | β |
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| A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling. | Lanzer JD et al. | β | 2025 | β |
| Activated signaling pathways and metabolic processes in disseminating myxoid glioneuronal tumors. | Chiang WY et al. | β | 2025 | β |
| Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes. | Sarma A et al. | β | 2025 | β |
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| A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes. | Noberini R et al. | β | 2025 | β |
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| A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury. | Zheng J et al. | β | 2025 | β |
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| An Annotated Biobank of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-NaΓ―ve and Longitudinal Samples during Neoadjuvant Chemotherapy. | Rinkenbaugh AL et al. | β | 2025 | β |
| An engineered glioblastoma model yields macrophage-secreted drivers of invasion. | Akins EA et al. | β | 2025 | β |
| An inhibitor of UHM splicing factors exerts anti-leukemic activity by altering cell cycle progression and reducing lysosome acidification. | Sabzvar MK et al. | β | 2025 | β |
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| A nomogram integrating machine learning-derived CT radiomics and clinical characteristics for prognostic assessment in patients with locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy with or without immunotherapy. | Zhu M et al. | β | 2025 | β |
| A Notch signal pathway related gene signature predicts overall survival in colorectal cancer. | Dong M et al. | β | 2025 | β |
| A novel alveoli-on-chip platform for modeling cyclic stretch in patient-derived alveolar epithelial cells cultured from organoids. | Hajari MA et al. | β | 2025 | β |
| A novel polypeptide inhibitor of MMP-1 attenuates the UVA-mediated skin aging. | Tang PX et al. | β | 2025 | β |
| A novel prognostic model for lung squamous cell carcinoma based on multi-omics analysis and machine learning. | Li J et al. | β | 2025 | β |
| A novel TRP channel-related prognostic model of glioma based on transcriptomics and single cell sequencing analysis. | Niu X et al. | β | 2025 | β |
| ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in Chronic Obstructive Pulmonary Disease. | Sui J et al. | β | 2025 | β |
| A pan-immunotherapy signature to predict intratumoral CD8<sup>+</sup> T cell expansions. | Takahashi M et al. | β | 2025 | β |
| A PCD-related prognostic signature and the oncogenic role of TRIM8 in osteosarcoma progression. | Zhang L et al. | β | 2025 | β |
| A phase Ib/II trial of neoadjuvant neratinib added to standard therapy in patients with HER2-positive or HR-positive/HER2-negative inflammatory breast cancer (including stage III and IV disease). | Lim B et al. | β | 2025 | β |
| Apoptotic signatures allow early and rapid screening of drug-induced liver injury to accelerate drug discovery. | Hellgren J et al. | β | 2025 | β |
| Application of Single-Cell Sequencing and Machine Learning in Prognosis and Immune Profiling of Lung Adenocarcinoma: Exploring Disease Mechanisms and Treatment Strategies Based on Circadian Rhythm Gene Signatures. | Mu Q et al. | β | 2025 | β |
| A predictive model for evaluating the risk of latent tuberculosis relapse via machine learning. | Wang C et al. | β | 2025 | β |
| A Prognostic Neuromodulation-Related Gene Signature Identifies Immunomodulation and Tumour-Associated Hallmarks in Glioblastoma. | Chow MY et al. | β | 2025 | β |
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| ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin. | SimΓ΅es-Sousa S et al. | β | 2025 | β |
| A robust ammonia metabolism gene signature identified by machine learning predicts prognosis and immunotherapy response in clear cell renal cell carcinoma. | Gong Z et al. | β | 2025 | β |
| Artificial intelligence-powered spatial analysis of tumor microenvironment in patients with non-small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitor. | Bang YH et al. | β | 2025 | β |
| Aryl hydrocarbon receptor restrains tonic cytokine responses by inhibiting microbiota sensing in monocytes. | Cros A et al. | β | 2025 | β |
| A set of downregulated pleiotropic genes are possible multi-omics biomarkers underlying the irritable bowel syndrome-non-alcoholic fatty liver disease comorbidity. | Hong J et al. | β | 2025 | β |
| A signature constructed with circadian rhythm-related genes to predict the prognosis and therapy response for low-grade gliomas. | Zhou Y et al. | β | 2025 | β |
| A single-cell atlas reveals the tumorigenesis and microenvironment status of primary tracheobronchial tumors. | Shu C et al. | β | 2025 | β |
| A spatially informed matrix normal model for gene co-expression analysis in spatial transcriptomics studies. | Tan C et al. | β | 2025 | β |
| Atypical p38 Kinase Signaling in Retinal Vascular Damage and Recovery. | Schulz L et al. | β | 2025 | β |
| Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility. | TrΕ‘eliΔ T et al. | β | 2025 | β |
| Baicalein Inhibits Proliferation, Migration, and Invasion of Mesothelioma Cells Through the p53-FOXM1 Signaling Axis. | Zheng XY et al. | β | 2025 | β |
| Baseline Body Fat Percentage Is Associated to Weight and Fat Mass Gain From High-Fat Overfeeding Over 8 Weeks. | Galgani JE et al. | β | 2025 | β |
| Beyond metaphor: quantitative reconstruction of Waddington landscape and exploration of cellular behavior. | Han Y et al. | β | 2025 | β |
| BloodCircR: A comprehensive database for human peripheral blood circular RNAs. | Yuan S et al. | β | 2025 | β |
| BNC2 as a novel driver of pancreatic cancer progression through transcriptional regulation of COL3A1 and epithelial-to-mesenchymal transition. | Li X et al. | β | 2025 | β |
| Bulk Transcriptome and Single-Cell Sequencing Datasets Reveal Key Programmed Cell Death Patterns in Radiation-Induced Lung Injury: Crosstalk Between NETosis and Macrophages' Responses. | Wang Q et al. | β | 2025 | β |
| Burn Injury Triggers Distinct Transcriptomic Profiles in Adipose Tissue of Adult and Aged Mice. | Bhattachan P et al. | β | 2025 | β |
| Bystin is a Prognosis and Immune Biomarker: From Pan-Cancer Analysis to Validation in Breast Cancer. | Aimaiti X et al. | β | 2025 | β |
| C1q drives neural stem cell quiescence by regulating cell cycle and metabolism through BAI1. | Piltti KM et al. | β | 2025 | β |
| Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy. | Baruch EN et al. | β | 2025 | β |
| Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiotherapy. | Richman CM et al. | β | 2025 | β |
| CD40 transcriptomic expression patterns across malignancies: implications for clinical trials of CD40 agonists. | Uehara Y et al. | β | 2025 | β |
| CD44v6 Drives Tumor Aggressiveness and Chemoresistance in Bladder Cancer | Lodewijk I et al. | β | 2025 | β |
| CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation. | Li J et al. | β | 2025 | β |
| Cell Decoder: decoding cell identity with multi-scale explainable deep learning. | Zhu J et al. | β | 2025 | β |
| CENTRA: knowledge-based gene contextuality graphs reveal functional master regulators by centrality and fractality. | Hause F et al. | β | 2025 | β |
| Characterization of PANoptosis-based markers for ischemic stroke and their appealing implications in improving prognosis and in glioma patients. | Zhang J et al. | β | 2025 | β |
| Characterization of the heterogeneity in oxidative stress and transcriptional programs within the in vivo microenvironment of ulcerative colitis. | Zhuang Y et al. | β | 2025 | β |
| Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation. | Nuccio SP et al. | β | 2025 | β |
| Chimeric hemagglutinin-based universal influenza mRNA vaccine induces protective immunity and bone marrow plasma cells in rhesus macaques. | Styles TM et al. | β | 2025 | β |
| Chromosomal instability degrades developmental phenotypes essential for anti-GD2 immunotherapy outcomes in high-risk neuroblastoma. | Rebernick RJ et al. | β | 2025 | β |
| Chronic sublethal exposure to methylmercury lengthens telomeres in developing zebra finches. | Davis RL et al. | β | 2025 | β |
| CircRNA signature predicts immunotherapy response in advanced non-small cell lung cancer. | Li X et al. | β | 2025 | β |
| Circulating fibroblasts and neutrophils co-expressing CDH11<sup>+</sup> and chemokine receptors in rheumatoid and psoriatic arthritis: a shared mechanism of 'arthritis spreading'? | Kyriakidi M et al. | β | 2025 | β |
| Circulating IFNΞ³-associated protein signatures predict response to neoadjuvant immunotherapy in patients with stage III melanoma. | Yang F et al. | β | 2025 | β |
| c-Jun inhibition mitigates chemotherapy-induced neurotoxicity in iPSC-derived sensory neurons. | Hew L et al. | β | 2025 | β |
| Clinical and Molecular Characterization of KRAS-Mutated Renal Cell Carcinoma. | Lopez Sanmiguel A et al. | β | 2025 | β |
| Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study. | Visentin A et al. | β | 2025 | β |
| Clinical, pathological and molecular characteristics of patients with disease recurrence despite pathologic response to neoadjuvant ipilimumab plus nivolumab in stage III melanoma. | Versluis JM et al. | β | 2025 | β |
| Clinical Stage Prompt Induced Multi-Modal Prognosis. | Jin T et al. | β | 2025 | β |
| Clonal diversity shapes the tumour microenvironment leading to distinct immunotherapy responses in metastatic urothelial carcinoma. | Kamatani T et al. | β | 2025 | β |
| COL8A1 as a pro-inflammatory mediator bridges immune evasion and therapy resistance in glioma. | Wang J et al. | β | 2025 | β |
| Combined bioinformatics and experimental validation identifies m1A-modified genes as potential diagnostic biomarkers in periodontitis and diabetes. | Wang K et al. | β | 2025 | β |
| Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice. | Ling L et al. | β | 2025 | β |
| Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia and <i>in vitro</i> hypoxia model. | Antipenko I et al. | β | 2025 | β |
| Comparison of automated and manual mRNA enrichment to automated rRNA depletion for whole-blood RNA-sequencing. | Awany D et al. | β | 2025 | β |
| Comprehensive Analysis of Epigenetic Signatures in Non-Small Cell Lung Cancer: Development and Validation of an Epigenetics-Based Prognostic Model for Drug Sensitivity Prediction. | Li Y et al. | β | 2025 | β |
| Comprehensive analysis of the role of diverse programmed cell death patterns in sepsis. | Yu X et al. | β | 2025 | β |
| Comprehensive and In-Depth Molecular and Pathway Studies of the Hippocampus in Alzheimer's Disease. | Tayani Pour F et al. | β | 2025 | β |
| Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway. | Truong MJ et al. | β | 2025 | β |
| Comprehensive Molecular Profiling of Cribriform Tumors: Identification of Recurrent 6q/9q Codeletion and CD38 Expression. | Sohier P et al. | β | 2025 | β |
| Comprehensive pan-cancer analysis of p62 reveals its contribution to shaping tumor microenvironment and anti-tumor immunity. | Nayeri Z et al. | β | 2025 | β |
| Comprehensive single-cell analysis reveals mast cells' roles in cancer immunity. | Qian H et al. | β | 2025 | β |
| Computational Approaches for Pathway-Centric Analysis of Protein Post-Translational Modifications. | MΓΌller J et al. | β | 2025 | β |
| Connectivity mapping with isotretinoin's transcriptomic signature identifies alternative therapeutics for severe acne. | Sennett ML et al. | β | 2025 | β |
| Consolidative nivolumab versus observation in unresectable stage III non-small cell lung cancer patients following neoadjuvant nivolumab plus chemotherapy and concurrent chemoradiotherapy (CA209-7AL): a randomized clinical trial. | Qiu B et al. | β | 2025 | β |
| Constructing a Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Glycosyltransferase Gene and Verification of Key Gene Identification. | Zhou C et al. | β | 2025 | β |
| Construction and validation of an ACTA2-based prognostic scoring model for colorectal adenocarcinoma. | Che X et al. | β | 2025 | β |
| Construction and validation of an oxidative phosphorylation-related gene signature in lung squamous cell carcinoma patients. | Dai N et al. | β | 2025 | β |
| Construction and validation of a prognostic model based on mitochondria-associated endoplasmic reticulum membranes gene signature in LUAD patients. | Zhang Q et al. | β | 2025 | β |
| Construction of a competitive endogenous RNA network and identification of potential regulatory axes in hypertrophic cardiomyopathy. | Gao R et al. | β | 2025 | β |
| Contrasting roles of KMT2C and KMT2D in breast cancer. | Tinsley E et al. | β | 2025 | β |
| Contrastive learning uncovers cellular interactions and morphologies in the tumor microenvironment of lung adenocarcinoma linked to immunotherapy response. | Le H et al. | β | 2025 | β |
| COPD-associated proteins as biomarkers and drug targets: Insights from genetic and proteomic analyses. | Lin X et al. | β | 2025 | β |
| c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT. | BakΔ±rdΓΆΔen D et al. | β | 2025 | β |
| CRISPR-Cas9 Genome and Double-Knockout Screening to Identify Novel Therapeutic Targets for Chemoresistance in Triple-Negative Breast Cancer. | Shao S et al. | β | 2025 | β |
| Cross-tissue enrichment patterns reveal functional clustering in normal human tissues from GTEx. | P S A et al. | β | 2025 | β |
| Cryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control. | Reyes EY et al. | β | 2025 | β |
| CT-based intratumoral heterogeneity quantification fusing deep learning radiomics for predicting lymph node metastasis in early-stage lung adenocarcinoma: a multicenter study. | Hu M et al. | β | 2025 | β |
| Cuproptosis-related gene TMPO affects the healing of diabetic foot ulcers through TGF-Ξ²/Smad signaling pathway. | Wang X et al. | β | 2025 | β |
| DDR1 as a key prognostic biomarker in non-small cell lung cancer: identification, validation, and potential therapeutic implications. | Lu R et al. | β | 2025 | β |
| DEAPLOG: Differential Expression Analysis and Pseudo-Temporal Locating and Ordering of Genes in Single-Cell Transcriptomic Data. | Zhang B et al. | β | 2025 | β |
| Deciphering the Osteoimmune Landscape in Subtalar Arthrodesis: A Single-Cell RNA Sequencing Approach. | Lee H et al. | β | 2025 | β |
| Deciphering the Role of Different Ceramide Synthases in the Human Cardiomyocyte Hypertrophic Response. | Wiley AM et al. | β | 2025 | β |
| Decoding intratumoral cyclooxygenase-2 signaling through multi-omics: insights from esophageal cancer and beyond. | Zhuang XY et al. | β | 2025 | β |
| Decoding the association between mucosal-associated invariant T cells and prostate cancer via multi-omics analysis. | Lai L et al. | β | 2025 | β |
| Deep generative modeling of sample-level heterogeneity in single-cell genomics. | Boyeau P et al. | β | 2025 | β |
| Deep immune profiling delineates hallmarks of disease heterogeneity in extrapulmonary tuberculosis. | Theobald SJ et al. | β | 2025 | β |
| Deep learning-based histomorphological subtyping and risk stratification of small cell lung cancer from hematoxylin and eosin-stained whole slide images. | Zhang Y et al. | β | 2025 | β |
| Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer. | Hibshman PS et al. | β | 2025 | β |
| Delineating transcriptomic signatures of in vitro human skeletal muscle models in comparison to in vivo references. | Van Puyvelde M et al. | β | 2025 | β |
| Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co-Cultured Neurons. | Kaplelach AK et al. | β | 2025 | β |
| DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer. | Chida K et al. | β | 2025 | β |
| Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study. | Zhang Z et al. | β | 2025 | β |
| Design of a potent interleukin-21 mimic for cancer immunotherapy. | Chun JH et al. | β | 2025 | β |
| Developing therapeutic strategies to target MCL1 and BCLXL in lethal prostate cancer. | Westaby D et al. | β | 2025 | β |
| Development and validation of a novel sodium-overload related genes signature for prognostic prediction in breast cancer: integrating bioinformatics and experimental approaches. | Feng Q et al. | β | 2025 | β |
| Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance. | Storey CM et al. | β | 2025 | β |
| Development of a prognostic prediction signature for idiopathic pulmonary fibrosis by integrating multiple programmed cell death-related genes and machine learning algorithms. | Sun J et al. | β | 2025 | β |
| Development of a translational radiobiology platform using pancreatic cancer patient-derived organoids for personalized radiation oncology. | Kessler C et al. | β | 2025 | β |
| Development of Cellular Energy Metabolism During Differentiation of Human iPSCs into Cortical Neurons. | DanaΔΓkovΓ‘ Ε et al. | β | 2025 | β |
| Dexamethasone enhances intestinal glucose absorption and TMPRSS2 expression with implications for hyperglycaemia and infection risk. | Visvanathan R et al. | β | 2025 | β |
| Diagnostic value of plasma heat shock protein 90Ξ± and inflammatory markers in prostate cancer. | Zhang W et al. | β | 2025 | β |
| Diet-induced obesity induces oxidative stress and enhances H3K4me3 levels, driving nonresolving inflammation and myelopoiesis in hematopoietic stem and progenitor cells. | Takahashi K et al. | β | 2025 | β |
| Differential effects of fetal bovine serum and human platelet lysate on mesenchymal stromal cell-mediated support of hematopoietic stem/progenitor cells: a functional and transcriptomic analysis. | Carreira MC et al. | β | 2025 | β |
| Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase-Deficient Renal Cell Carcinoma. | Zacharias NM et al. | β | 2025 | β |
| Differentiation latency and dormancy signatures define fetal liver hematopoietic stem cells at single-cell resolution. | Ishida T et al. | β | 2025 | β |
| Discovering anticancer drug target combinations via network-informed signaling-based approach. | Yavuz BR et al. | β | 2025 | β |
| Disruption of fibroblast MYD88 signaling promotes antitumor immunity in pancreatic ductal adenocarcinoma. | Korah M et al. | β | 2025 | β |
| Distinct liver sections exhibit sex-specific gene expression patterns in Lewis rats. | Rajcsanyi LS et al. | β | 2025 | β |
| Disulfidptosis-associated gene signature predicts prognosis and radioresistance in NSCLC. | Liu J et al. | β | 2025 | β |
| Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity. | Dalit L et al. | β | 2025 | β |
| Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity. | Eyunni S et al. | β | 2025 | β |
| Drug targeting of the monocarboxylate transporter MCT4 is a novel treatment strategy for metastatic ccRCC. | Menig-Benzig LS et al. | β | 2025 | β |
| DSA-DeepFM: a dual-stage attention-enhanced DeepFM model for predicting anticancer synergistic drug combinations. | Gu Y et al. | β | 2025 | β |
| Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML. | Brault L et al. | β | 2025 | β |
| Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12. | Ingersoll AJ et al. | β | 2025 | β |
| Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization. | Yabaji SM et al. | β | 2025 | β |
| ECM-based molecular subtypes define prognostic, EMT status, and therapeutic diversity in IDH-mutant gliomas. | Wei Y et al. | β | 2025 | β |
| Effect of statins on IL-10 signaling and production by chronic lymphocytic leukemia cells. | Wang G et al. | β | 2025 | β |
| Elevated KNSTRN as a potential indicator for triple-negative breast cancer progression and immune infiltration. | Song Y et al. | β | 2025 | β |
| Elucidating Pancreatic Ductal Adenocarcinoma Carcinogenesis at Single-Cell Resolution and Identifying Subtype Specific Drug Candidates. | Chen J et al. | β | 2025 | β |
| Endothelial septin 4 reduction contributes to lipopolysaccharide-induced acute lung injury by disrupting endothelial barrier integrity and promoting infiltration of ISG<sup>+</sup> cells. | Li DD et al. | β | 2025 | β |
| Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity. | Xiao Z et al. | β | 2025 | β |
| Environmentally relevant lead exposure impacts gene expression in SH-SY5Y cells throughout neuronal differentiation. | Morgan RK et al. | β | 2025 | β |
| Epigenetic modifications of the PHOX2A and CDH2 genes expression- new insights into the pathogenesis of multiple myeloma. | Εuczkowska K et al. | β | 2025 | β |
| Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC. | Zamuner FT et al. | β | 2025 | β |
| Establishment and transcriptomic characterization of canine organoids from multiple tissues. | Zdyrski C et al. | β | 2025 | β |
| Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity. | Gerhardt A et al. | β | 2025 | β |
| Evaluation of biomarkers and immune microenvironment of gestational diabetes mellitus evidence from omics data and machine learning. | Chen M et al. | β | 2025 | β |
| Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy. | Sun S et al. | β | 2025 | β |
| Exogenous estrogen enhances T cell activation in male primates. | Hahn PA et al. | β | 2025 | β |
| Expanded CD16<sup>+</sup>CD56<sup>+</sup>Granzyme B<sup>+</sup> NK like CD8<sup>+</sup> T cells an off target effect of bruton's tyrosine kinase inhibitors in WaldenstrΓΆm macroglobulinemia. | Hastak P et al. | β | 2025 | β |
| Exploration of oxidative stress-mediated genetic toxicology modes of action using a pathway analysis, Connectivity Mapping, and transcriptional benchmark dosing-based framework. | De Abrew KN et al. | β | 2025 | β |
| Exploration of prognosis and immune infiltration characteristics in glioblastoma multiforme based on lipid metabolism related genes. | Li PC et al. | β | 2025 | β |
| Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy. | Lu F et al. | β | 2025 | β |
| Exploring the biological functions and immune regulatory roles of IRAK3, TNFRSF1A, CX3CR1, and JUNB in T2DM combined with MAFLD: integrated bioinformatics and single-cell analysis. | Wang Q et al. | β | 2025 | β |
| Exploring the Glycolytic Mechanisms in "Driver Gene-Negative" Lung Adenocarcinoma (LUAD): A Single-Cell RNA Sequencing Approach to Identify the MIF-HIF-1Ξ± Axis. | Yang HS et al. | β | 2025 | β |
| Exploring transcriptomic and genomic differences between susceptible and resistant fetal pigs to maternal PRRSV infection at late gestation. | Ko H et al. | β | 2025 | β |
| Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O<sub>2</sub> =2β―%) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O<sub>2</sub> β₯ 21β―%) in HTR-8/SVneo cells. | Stein FH et al. | β | 2025 | β |
| Expression and clinical value of key m<sup>6</sup>A RNA modification regulators in tuberculosis. | Du H et al. | β | 2025 | β |
| Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature. | Paladini MS et al. | β | 2025 | β |
| Federated Deep Learning Enables Cancer Subtyping by Proteomics. | Cai Z et al. | β | 2025 | β |
| Ferroptosis-related gene analysis revealing novel biomarkers and therapeutic targets in diffuse large B-cell lymphoma. | Liu L et al. | β | 2025 | β |
| Fibroblast TGF-Ξ² signaling defines spatial tumor ecosystems linked to immune checkpoint blockade resistance. | Lee SY et al. | β | 2025 | β |
| Finding the True Responders: Stratifying dMMR/MSI-H Tumors for ICI Response. | Kim N et al. | β | 2025 | β |
| FLT3LG as an inflammatory hub bridging tumor immune surveillance to therapy response in breast cancer. | Lu Y et al. | β | 2025 | β |
| Fosl1 is a transcriptional effector of <i>BRAF</i> <sup>V600E</sup>-driven intestinal tumorigenesis. | Alam Z et al. | β | 2025 | β |
| FTO Fuels AΞ²<sub>1-40</sub>-Induced Retinal Pigment Epithelium Cell Injury Associated With Pyroptosis by Erasing m6A Methylation of the lncRNA Neat1. | Xue Q et al. | β | 2025 | β |
| Functional Determinants and Evolutionary Consequences of Pleiotropy in Complex and Mendelian Traits. | Barbitoff YA et al. | β | 2025 | β |
| Functional role of granulocytic myeloid-derived suppressor cells in CAR-T therapy: insights from single-cell RNA sequencing in multiple myeloma. | Zhang C et al. | β | 2025 | β |
| Fusion-Negative NTRK Overexpression Exhibit Biological Relevance in Colorectal Cancer: Implications for Prediction of Responses to Kinase Inhibitors. | Alfahed A | β | 2025 | β |
| FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis. | Qin K et al. | β | 2025 | β |
| GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression. | Suzuki H et al. | β | 2025 | β |
| GeDi: simplifying gene set distances for enhanced omics interpretation in R/Bioconductor. | Nedwed AS et al. | β | 2025 | β |
| Gelatin-Based Soft-Tissue Sarcoma Organoids Recapitulate Patient Tumor Characteristics. | Han K et al. | β | 2025 | β |
| Gene expression differences in differentially methylated sites associated with HIV status and cocaine use. | Earley EJ et al. | β | 2025 | β |
| Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Extract in BT-549 Triple-Negative Breast Cancer Cells. | Visan S et al. | β | 2025 | β |
| Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines. | Balik-Meisner M et al. | β | 2025 | β |
| GeneRAIN: multifaceted representation of genes via deep learning of gene expression networks. | Su Z et al. | β | 2025 | β |
| Generation and applications of an expandable and mature hiPSC-derived liver organoid. | Liu S et al. | β | 2025 | β |
| Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets. | Vijay V et al. | β | 2025 | β |
| GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis. | Ortega-Legarreta A et al. | β | 2025 | β |
| Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk. | Li B et al. | β | 2025 | β |
| Genetic relationship between SjΓΆgren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis. | Zhou Y et al. | β | 2025 | β |
| Glial-to-mesenchymal transition of tumor Schwann cells drives the genetic burden in MPNSTs from neurofibromatosis type 1 mouse model. | Radomska KJ et al. | β | 2025 | β |
| Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis. | Yang G et al. | β | 2025 | β |
| Global transcriptional analysis of human FHs 74 Int intestinal epithelial cells after exposure to advanced glycation end products. | Schwertner K et al. | β | 2025 | β |
| Glycolysis-related radiosensitivity signature for predicting radiotherapy response in breast cancer. | Lin X et al. | β | 2025 | β |
| GOREA: Unbiased Interpretation of Functional Enrichment. | Lee H et al. | β | 2025 | β |
| GRB10 as a pan-cancer biomarker linking oncogenic signaling, immunosuppression, and immunotherapy resistance. | Guo H et al. | β | 2025 | β |
| Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens. | Chac D et al. | β | 2025 | β |
| Harnessing Senolytics and PARP Inhibition to Expand the Antitumor Activity of CDK4/6 Inhibitors in Prostate Cancer. | Brandariz J et al. | β | 2025 | β |
| Hemopexin Suppresses Hepatocellular Carcinoma via TNF-Ξ±-Mediated Mitochondrial Apoptosis. | Ren L et al. | β | 2025 | β |
| Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging. | Civiletto G et al. | β | 2025 | β |
| Heterogeneity of Acute Myeloid Leukemia patients explored through single-cell and single-sample gene regulatory networks. | Fernandes L et al. | β | 2025 | β |
| High-fat diet disrupts a septal control on feeding to promote obesity in male mice. | Jiang S et al. | β | 2025 | β |
| High PARP1 expression is associated with proliferative tumor biology in breast cancer. | Ghasemi F et al. | β | 2025 | β |
| High-precision cell-type mapping and annotation of single-cell spatial transcriptomics with STAMapper. | Shen Q et al. | β | 2025 | β |
| Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. | Abrol R et al. | β | 2025 | β |
| HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4+ T cells. | Lewis CA et al. | β | 2025 | β |
| Host-specific bacterial modulation of airway gene expression and alternative splicing. | Horvath M et al. | β | 2025 | β |
| Human axillary lymph node T follicular helper (Tfh) and Precursor-Tfh cells exhibit functional flexibility following seasonal influenza vaccination. | Law H et al. | β | 2025 | β |
| Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers. | Khan N et al. | β | 2025 | β |
| Hydroethanolic Soy Extract Rich in Isoflavones Protects Dystrophic Mutant Mice From Oxidative Stress and Inflammation via the ROS/NF-ΞΊB Feedback Pathway. | Nascimento BG et al. | β | 2025 | β |
| Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity. | Chang TG et al. | β | 2025 | β |
| Identification and analysis of diverse cell death patterns in osteomyelitis via microarray-based transcriptome profiling and clinical data. | Feng T et al. | β | 2025 | β |
| Identification and experimental validation of biomarkers associated with the endocannabinoid system in major depressive disorder. | Wang L et al. | β | 2025 | β |
| Identification and mechanism of key genes in inflammatory response of chronic otitis media in rats. | Li O et al. | β | 2025 | β |
| Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease. | Wang W et al. | β | 2025 | β |
| Identification and validation of cell senescence genes in recurrent spontaneous abortion via multiple bioinformatics algorithms. | Wei Y et al. | β | 2025 | β |
| Identification and validation of intratumoral microbiome associated with sensitization to immune checkpoint inhibitors. | Chen J et al. | β | 2025 | β |
| Identification and validation of key biomarkers of the glycolysis-ketone body metabolism in heart failure based on multi-omics and machine learning. | Xiao N et al. | β | 2025 | β |
| Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq. | Qian D et al. | β | 2025 | β |
| Identification and validation of the important role of tryptophan-related gene CYP1B1 in the development and progression of sepsis. | Chen LH et al. | β | 2025 | β |
| Identification and Verification of Biomarkers Related to Polyamine Metabolism in Diabetic Nephropathy. | Zhou S et al. | β | 2025 | β |
| Identification of apoptosis-related genes as potential biomarkers and therapeutic targets in cystic fibrosis patients progressing to pulmonary nontuberculous mycobacterial disease. | Pan J et al. | β | 2025 | β |
| Identification of cancer-associated fibroblast signature genes for potential biomarkers in cholangiocarcinoma: a Mendelian randomization study. | Hu S et al. | β | 2025 | β |
| Identification of ferroptosis-genes associated with pediatric inflammatory bowel disease bioinformatics and machine learning approaches. | Xu Z et al. | β | 2025 | β |
| Identification of key genes associated with muscle atrophy after spinal cord injury and experimental verification in rats. | Wang X et al. | β | 2025 | β |
| Identification of Mitophagy-Related Genes and Analysis of Immune Infiltration in Atherosclerosis. | Zhang J et al. | β | 2025 | β |
| Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity. | Li XX et al. | β | 2025 | β |
| Identification of novel gene expression programs in thrombin-stimulated hepatic stellate cells. | Mac NA et al. | β | 2025 | β |
| Identification of oxidative stress-responsive genes in recurrent miscarriage and their role in disease pathogenesis. | Wang M et al. | β | 2025 | β |
| Identification of SLC7A1 as a potential therapeutic target for high-grade meningioma. | Song L et al. | β | 2025 | β |
| Identification of SNCA and DRD2 as key genes linking parkinson's disease and circadian rhythm through bioinformatics analysis. | Zhang J et al. | β | 2025 | β |
| Identification of type 2 diabetes- and obesity-associated human Ξ²-cells using deep transfer learning. | Roy G et al. | β | 2025 | β |
| Identifying autophagy-related biomarkers in the treatment of renal interstitial fibrosis with Shen Fukang through network pharmacology. | Liu S et al. | β | 2025 | β |
| Identifying Genetic Variants in Patients With Cefaclor-Induced Anaphylaxis Using Human Leukocyte Antigen Typing and Whole-Exome Sequencing. | Kim SR et al. | β | 2025 | β |
| Identify novel molecular subtypes of lung adenocarcinoma to predict treatment response and prognosis. | Shi YX et al. | β | 2025 | β |
| IGF1R-targeted delivery of a bridged nucleic acid oligonucleotide-peptide conjugate for microRNA-21 inhibition in triple-negative breast cancer. | Jin Y et al. | β | 2025 | β |
| IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling. | Ghimire S et al. | β | 2025 | β |
| IL-6<sup>+</sup> fibroblasts contribute to shaping the pro-inflammatory microenvironment in severe periodontitis after non-surgical periodontal therapy. | Chen J et al. | β | 2025 | β |
| Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C. | Xu P et al. | β | 2025 | β |
| Improved reconstruction of single-cell developmental potential with CytoTRACE 2. | Kang M et al. | β | 2025 | β |
| InCURA: integrative gene clustering based on transcription factor binding sites. | Rinck L et al. | β | 2025 | β |
| Inferring pathway activity from single-cell and spatial transcriptomics data with PaaSc. | Liao X et al. | β | 2025 | β |
| Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia. | Prummel KD et al. | β | 2025 | β |
| Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy. | Hirade K et al. | β | 2025 | β |
| Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia. | Lewczuk A et al. | β | 2025 | β |
| Integrated genomics reveals cellular senescence-driven molecular networks and immune crosstalk in myopia pathogenesis. | Su W et al. | β | 2025 | β |
| Integrated machine learning identifies biomarkers for bilirubin-induced Alzheimer's disease-like lesions in neonates and adults. | Bao W et al. | β | 2025 | β |
| Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD. | Gonzalez-Acera M et al. | β | 2025 | β |
| Integrated multi-omics analysis reveals key hub genes and mechanisms in calcific aortic stenosis. | Wang FX et al. | β | 2025 | β |
| Integrated pathway analysis identifies prognostically relevant subtypes of glioblastoma characterized by abnormalities in multi-omics. | Zhang P et al. | β | 2025 | β |
| Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival. | Chen Y et al. | β | 2025 | β |
| Integrated Transcriptomic Analysis of S100A8/A9 as a Key Biomarker and Therapeutic Target in Sepsis Pathogenesis and AI Drug Repurposing. | Dave K et al. | β | 2025 | β |
| Integrated transcriptomic and co-expression network analysis identifies <i>HIF1A</i> as a key immune regulator in biliary atresia. | Wang C et al. | β | 2025 | β |
| Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer's disease. | Wang X et al. | β | 2025 | β |
| Integrating COX-2, stromal PD-L1, and T-cell infiltration enhances prognostic stratification in colorectal cancer. | Topi G et al. | β | 2025 | β |
| Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses. | Saad R et al. | β | 2025 | β |
| Integrating prognosis-related genes with immune-related gene signature for development and validation of a survival stratification model for early-stage colorectal cancer. | Zhou Z et al. | β | 2025 | β |
| Integrative analysis identified <i>THBS1</i> as a key prognostic biomarker with therapeutic vulnerability in patients with laryngeal cancer. | Huang S et al. | β | 2025 | β |
| Integrative analysis identifies FERMT3 as a key regulator of metabolic reprogramming in keloid scarring and metabolic syndrome. | Lin Q et al. | β | 2025 | β |
| Integrative analysis of angiogenesis-related genes highlights prognostic indicators in colorectal cancer through single-cell sequencing and immune infiltration analysis. | Bhola N et al. | β | 2025 | β |
| Integrative analysis of RiboSis-related gene expression in colorectal cancer: implications for prognosis and immunotherapy. | Song W et al. | β | 2025 | β |
| Integrative bioinformatics analysis for identifying the mitochondrial-related gene associated with immune infiltration in sarcopenia. | Yan H et al. | β | 2025 | β |
| Integrative Genomic and Immune Profiling to Identify and Characterize High-Risk Subgroups in Acute Myeloid Leukemia: Development of a 20-Gene Predictive Signature and Its Clinical Implications. | Karagoz K et al. | β | 2025 | β |
| Integrative metaprogram analysis reveals transcriptional dysregulation of oxidative stress response in granulosa cells from polycystic ovary syndrome. | Li Y et al. | β | 2025 | β |
| Integrative multi-omics analysis proposes a metabolic classification of gliomas: distinct metabolic states, immune infiltration, and prognosis. | Zhu Q et al. | β | 2025 | β |
| Integrative profiling strategies to guide personalized therapy in mantle cell lymphoma: a pilot study. | Liu Y et al. | β | 2025 | β |
| Integrative single-cell and bulk RNA sequencing of lactate metabolism identifies PDP-1 as a prognostic biomarker in breast cancer. | Yang Q et al. | β | 2025 | β |
| Integrative single-cell and spatial transcriptomics analysis reveals FLAD1 as a regulator of the immune microenvironment in hepatocellular carcinoma. | Zhu P et al. | β | 2025 | β |
| Integrative Transcriptome and Machine Learning Analysis Uncovers Critical STAT3/GREM2 Signaling Mechanisms in Dexamethasone Treatment of Hashimoto's Thyroiditis. | Zeng H et al. | β | 2025 | β |
| Integrative transcriptomic analysis identifies an oxidative stress-associated diagnostic signature for myocardial infarction. | Zhang Y et al. | β | 2025 | β |
| Integrative transcriptomic analysis of Korean high-grade serous ovarian cancer. | Kim H et al. | β | 2025 | β |
| Integrative transcriptomic and genomic insights into diabetic kidney disease: evidence from multi-omics analysis and experimental validation. | Chen S et al. | β | 2025 | β |
| Integrative transcriptomic profiling and machine learning reveal hypoxia-associated molecular signatures for precision diagnosis in thyroid eye disease. | Qian W et al. | β | 2025 | β |
| Interferon alpha-inducible protein 27 (IFI27) inhibits hepatitis B virus (HBV) transcription through downregulating cellular transcription factor C/EBPΞ±. | Yu X et al. | β | 2025 | β |
| Interleukin-6 blockade does not impair exercise-induced glucose uptake and insulin sensitivity in rheumatoid arthritis. | Casale AR et al. | β | 2025 | β |
| Intracellular <i>Acinetobacter baumannii</i> acts as a transient reservoir in lung infection via a "persist and resist" strategy. | Janet-Maitre M et al. | β | 2025 | β |
| Intra-tumoral hypoxia promotes CD8<sup>+</sup> T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4. | Alicea Pauneto CDM et al. | β | 2025 | β |
| Invasive Lobular Carcinoma Has Higher Immune Response Than Invasive Ductal Carcinoma in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers. | Yee G et al. | β | 2025 | β |
| Investigating the impact of MCTP2 on immune suppression and drug resistance in glioblastoma. | Chen Y et al. | β | 2025 | β |
| In vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target. | Fu C et al. | β | 2025 | β |
| Iron-sensitive RNA regulation by poly C-binding proteins. | Goda GA et al. | β | 2025 | β |
| Knockdown of long non-coding RNA BISPR attenuates the proinflammatory cytokine IL-6 production in human microglia. | Wang Y et al. | β | 2025 | β |
| KPNA2 silencing sensitizes triple-negative breast cancer to chemotherapy by promoting multipolar division and suppressing DNA damage repair. | Cai Y et al. | β | 2025 | β |
| LEP and FOXO1 genes, as a proposed tumor suppressor autophagic cell death related genes, can be targeted by antidiabetic therapy in nondiabetic breast cancer patients. | Duran GA et al. | β | 2025 | β |
| Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy. | Fonseca MM et al. | β | 2025 | β |
| Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. | Hildebrandt X et al. | β | 2025 | β |
| Lipid metabolism-related genes regulate the immune microenvironment during ex vivo lung perfusion for lung transplants. | Zhang Y et al. | β | 2025 | β |
| Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. | Yabaji SM et al. | β | 2025 | β |
| Lipoxin A4 Regulates M2 Macrophage-Derived Exosomal miR-25-5p to Protect Cell Pyroptosis in Bronchopulmonary Dysplasia. | Chen T et al. | β | 2025 | β |
| Longitudinal gene expression analysis in COVID-19 sepsis highlights dynamic immune, cellular, and metabolic dysfunction in high severity patients. | An AY et al. | β | 2025 | β |
| Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance. | Hou G et al. | β | 2025 | β |
| Long noncoding RNA-dependent control of Myc transcriptional bursting. | Li Q et al. | β | 2025 | β |
| Long non-coding RNAs define favourable biology in high-risk non-muscle-invasive bladder cancer. | Weng R et al. | β | 2025 | β |
| LOSTdb: a manually curated multi-omics database for lung cancer research. | Luo H et al. | β | 2025 | β |
| <i>CPSF1</i> Is Co-Amplified with <i>MYC</i> but Is Independently Associated with Alternative Polyadenylation in Cancer. | Alahmari AA | β | 2025 | β |
| <i>In Vitro</i> and <i>Ex Vivo</i> evidence that pharmacological induction of the hypoxia response pathway efficiently restricts measles and Nipah virus infections. | Canus L et al. | β | 2025 | β |
| <i>Spp1</i> Appears to Be a Key Gene for Sporadic Obstructive Hydrocephalus in the Absence of AQP4. | EchevarrΓa M et al. | β | 2025 | β |
| Lung NR3C1<sup>+</sup> and CXCR6<sup>high</sup> T cells distinguish immunopathogenesis of human emphysema. | Zhang Y et al. | β | 2025 | β |
| Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner. | Lindstedt AJ et al. | β | 2025 | β |
| Lysosomal reduced thiols are essential for mouse embryonic development. | Adelmann CH et al. | β | 2025 | β |
| m7G-related gene signatures determine prognosis in triple-negative breast cancer. | Li Y et al. | β | 2025 | β |
| Machine learning analysis of coagulation-related genes for breast cancer diagnosis and prognosis prediction. | Li S et al. | β | 2025 | β |
| Machine learning combined with omics-based approaches reveals T-lymphocyte cellular fate imbalance in abdominal aortic aneurysm. | Li D et al. | β | 2025 | β |
| Machine learning constructs a ferroptosis related signature for predicting prognosis and drug sensitivity in lung cancer. | Li Z et al. | β | 2025 | β |
| Machine learning-driven dissection of the obesity-ccRCC interface: FCGR2A emerges as a central coordinator of tumor-immune crosstalk. | He Z et al. | β | 2025 | β |
| Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and antitumoral activity upon IL-10 or TGFΞ² stimulation. | Traxel S et al. | β | 2025 | β |
| MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells. | Nangia V et al. | β | 2025 | β |
| Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension. | Cober ND et al. | β | 2025 | β |
| Mapping Macrophage Diversity in Coats' Disease: A Lipid-Associated Subset in the Pathogenesis of Exudative Retinopathy. | Xie R et al. | β | 2025 | β |
| Mapping the FOXA1 Interactome in ER+ Breast Cancer Cells Using Proximity Labeling Reveals Novel Interactions with the Orphan Nuclear Receptor NR2C2. | Plagens RN et al. | β | 2025 | β |
| Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring. | Zhao A et al. | β | 2025 | β |
| Maternal monocyte-derived IFN-Ξ±1 triggers early fetal demise. | Wang D et al. | β | 2025 | β |
| Mathematical strategies for predicting resistant subpopulations from scRNAseq data of a PANC-1 3D tissue model: Insight into gemcitabine resistance and TGFB1-induced invasion and EMT. | Caliskan A et al. | β | 2025 | β |
| Matrix stiffness drives squamous cell carcinoma progression via a Piezo1-mediated mechanotransduction feedback loop. | Jiang Z et al. | β | 2025 | β |
| Mechanistic insights into FUNDC2P4 and HSF1 regulation of EMT in residual hepatocellular carcinoma following insufficient radiofrequency ablation. | Tang N et al. | β | 2025 | β |
| Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation. | Song Z et al. | β | 2025 | β |
| Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival. | Dzama-Karels M et al. | β | 2025 | β |
| Meta-Analysis of Ocy-454 Showed Interrupted Osteocyte Maturation in Spaceflight Affects SOST Expression and Hypoxic Response. | Honjo M et al. | β | 2025 | β |
| Metabolic and aging related gene risk score for therapeutic stratification and precision oncology in gastric cancer. | Zhang Y et al. | β | 2025 | β |
| Metabolic-stem cell crosstalk in PD: NK1 cells as key mediators from a bioinformatics perspective. | Zhao J et al. | β | 2025 | β |
| Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability. | Czogalla J et al. | β | 2025 | β |
| Metalloproteinase-9 as a Pyroptosis-Hypoxia Synergy Effector Drives Immune Remodeling in Ischemic Stroke: A Multi-Omics Validated Diagnostic Biomarker and Therapeutic Target. | Wu J et al. | β | 2025 | β |
| Methylomic Signature and Epigenetic Damage Modulation of Bronte Pistachio (<i>Pistacia vera</i> L.) Hydrophilic Extract in Differentiated CaCo-2 Cells. | Cruciata I et al. | β | 2025 | β |
| MmuPV1 E7 promotes phenotypes associated with "high-risk" HPV infection in mouse keratinocytes. | Duxbury KR et al. | β | 2025 | β |
| Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs. | Valencia C et al. | β | 2025 | β |
| Modelling reliable metabolic phenotypes by analysing the context-specific transcriptomics data. | Kumar S P et al. | β | 2025 | β |
| Molecular features of congenital cytomegalovirus infection in neonatal mouse brain at single-cell resolution. | Mei MJ et al. | β | 2025 | β |
| Molecular signals associated with intraperitoneal chemotherapy resistance in gastric cancer with peritoneal metastasis through PIPS GC trial integrated translational research. | Seo WJ et al. | β | 2025 | β |
| Mouse-Specific Single cell cytokine activity prediction and Estimation (MouSSE). | Javaid A et al. | β | 2025 | β |
| Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix. | Gao H et al. | β | 2025 | β |
| Multidimensional tumor-blood profiling uncovers systemic lymphocyte-monocyte imbalance in pituitary neuroendocrine tumors. | Dai Y et al. | β | 2025 | β |
| Multi-disease transcriptomic analysis of sex hormone genes reveals a novel prognostic model for thyroid cancer with breast cancer correlations. | Qiao L et al. | β | 2025 | β |
| Multimodal integration strategies for clinical application in oncology. | Zhang B et al. | β | 2025 | β |
| Multi-Modal Profiling Reveals SERPINB3-Driven Immune Evasion and Stromal Immune Mimicry in Triple-Negative Breast Cancer. | Doha ZO | β | 2025 | β |
| Multiomics Analysis of Skeletal Muscle Identifies Dysregulation of Hypoxia-Induced Genes in Peripheral Artery Disease. | Ismaeel A et al. | β | 2025 | β |
| Multi-omics analysis of the potential association between ageing and rheumatoid arthritis and screening of potential therapeutic targets. | Yun X et al. | β | 2025 | β |
| Multi-omics and comprehensive multi-trait analysis identify shared genetic etiology of heart failure and related cancers. | Shui W et al. | β | 2025 | β |
| Multi-omics and machine learning identify FN1 and ALDH2 as diagnostic biomarkers and therapeutic targets in early and late diabetic kidney disease. | Lin J et al. | β | 2025 | β |
| Multi-omics identification of quantitative trait loci associated with vascular pathogenesis and diagnostic potential in chronic venous disease. | Chuang CH et al. | β | 2025 | β |
| Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma. | Rai A et al. | β | 2025 | β |
| Multi-omics reveals changes in astrocyte fatty acid metabolism during early stages of Alzheimer's disease. | Zhong J et al. | β | 2025 | β |
| Multi-Omics Tumor Immunogenicity Score Predicts Immunotherapy Outcome and Survival. | Gschwind A et al. | β | 2025 | β |
| Multiplexed Imaging Mass Cytometry Reveals Tumor-immune Microenvironment-dependent Hormone Receptor Expression in Adult-Type Ovarian Granulosa Cell Tumors. | Khlebus EY et al. | β | 2025 | β |
| Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia. | Quoc-Huy Trinh V et al. | β | 2025 | β |
| Mutant p53 variants differentially impact replication initiation and activate cGAS-STING to affect immune checkpoint inhibition. | Liu K et al. | β | 2025 | β |
| Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state. | Rominger MC et al. | β | 2025 | β |
| Mutational landscape of triple-negative breast cancer in African American women. | Yao S et al. | β | 2025 | β |
| MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition. | Lueg GA et al. | β | 2025 | β |
| Natural language processing of gene descriptions for overrepresentation analysis with GeneTEA. | Boyle IA et al. | β | 2025 | β |
| Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation. | Gonzalez-Hurtado E et al. | β | 2025 | β |
| Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP-CD74 signaling and CXCL1 as diagnostic biomarkers. | He S et al. | β | 2025 | β |
| Nitro Dihydrocapsaicin Attenuates Hyperosmotic Stress-Induced Inflammation in the Corneal Epithelial Cells via SIRT1/Nrf2/HO-1 Pathway. | Ngoenkam J et al. | β | 2025 | β |
| Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodeling. | Yoo M et al. | β | 2025 | β |
| Nonsense-mediated mRNA decay inhibits TRAF6-dependent anti-tumor immunity in colorectal cancer. | Wang Y et al. | β | 2025 | β |
| NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice. | Park S et al. | β | 2025 | β |
| Off-pore Nucleoporin sPOM121 Transcriptionally Propels Ξ²-Catenin-driven Tumor Progression and Immune Escape in Prostate Cancer. | Kirthika P et al. | β | 2025 | β |
| Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies. | Rassner M et al. | β | 2025 | β |
| One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer. | Joo S et al. | β | 2025 | β |
| Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down-Regulated Senescent Epidermal Basal Cells. | Yamamoto S et al. | β | 2025 | β |
| Ovine macrophage identity and plasticity: novel insights into CSF-driven polarization and species-specific responses. | Hecker YP et al. | β | 2025 | β |
| Oxidized phosphatidylcholines activate NOX1-mediated oxidative stress response and shift glucose metabolism in cardiac cells. | Licznerska AA et al. | β | 2025 | β |
| P4HA1 facilitates SPP1+ tumor-associated macrophages by activating the hypoxia pathway in head and neck squamous cell carcinoma. | Liu Y et al. | β | 2025 | β |
| PACT is requisite for prostate cancer cell proliferation. | Beveridge DJ et al. | β | 2025 | β |
| PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer. | Young AA et al. | β | 2025 | β |
| Pan-cancer analysis and experimental verification of its roles and clinical significance of SLC2A3 in kidney renal clear cell carcinoma. | Lyu Z et al. | β | 2025 | β |
| Pan-cancer and machine learning reveal the role of cell adhesion molecules in prognosis, immune remodeling, and anti-tumour therapy in lower-grade gliomas. | Zheng X et al. | β | 2025 | β |
| Pan-cancer gene set discovery via scRNA-seq for optimal deep learning based downstream tasks. | Kim JH et al. | β | 2025 | β |
| PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma. | Zhao Q et al. | β | 2025 | β |
| Paraptosis-related genes regulate tumor immune microenvironment and predict prognosis in breast cancer. | Dong Z et al. | β | 2025 | β |
| Parvovirus B19 and Cellular Transcriptome Dynamics in Differentiating Erythroid Progenitor Cells. | Fasano E et al. | β | 2025 | β |
| Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry. | Gheybi K et al. | β | 2025 | β |
| PDK4 Regulates Inflammatory Injury in Acute-on-chronic Liver Failure by Phosphorylating STAT1-mediated M1 Polarization of Macrophages. | Dong S et al. | β | 2025 | β |
| Personalized transcriptional network analysis links age-related loss of gene coordination to individual biological aging. | Wang HT et al. | β | 2025 | β |
| Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAF<sup>V600E</sup> metastatic colorectal cancer. | Morris VK et al. | β | 2025 | β |
| Phase 1b Study of Dazostinag plus Pembrolizumab after Hypofractionated Radiotherapy in Patients with Select Advanced Solid Tumors. | Cooper BT et al. | β | 2025 | β |
| Phosphorylation of c-Myc at Ser62 via the protein kinase activity of acetaldehyde dehydrogenase 18A1 promotes tumor growth. | Wang D et al. | β | 2025 | β |
| Physics-informed AI with chemical master equation dynamics for driver-gene subclone detection and risk labeling. | Atitey K et al. | β | 2025 | β |
| PI5P4KΞ± promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer. | Arora GK et al. | β | 2025 | β |
| PLAID: ultrafast single-sample gene set enrichment scoring. | Zito A et al. | β | 2025 | β |
| Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition. | Shneider BL et al. | β | 2025 | β |
| Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health. | Muller MA et al. | β | 2025 | β |
| Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin. | Outla Z et al. | β | 2025 | β |
| Polystyrene microplastics are internalized by human gingival fibroblasts, enhance cell motility and induce molecular changes revealed through proteomic analysis. | Di Cintio F et al. | β | 2025 | β |
| PPI-based screening of hub genes related to sepsis migration/pyroptosis and immune infiltration analysis. | Ma X et al. | β | 2025 | β |
| Predictive value of immunomodulatory-related genes for the prognosis of lung adenocarcinoma based on bioinformatics analysis. | Yang L et al. | β | 2025 | β |
| Predictive value of MHC-related genes in cervical cancer: implications for immunotherapy and prognostic nomogram development. | Xi M et al. | β | 2025 | β |
| Primary keratinocyte model of actinic keratosis reveals UV-induced DNA damage accumulation and persistent IFN signaling. | Elsbroek L et al. | β | 2025 | β |
| PR inhibition stimulates G6PD expression to enhance malignancy in luminal breast cancer. | Jeong JW et al. | β | 2025 | β |
| PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in Rhabdomyosarcoma. | Prada E et al. | β | 2025 | β |
| Prognostic and microenvironmental analysis of pancreatic cancer by tumor location. | Chen Z et al. | β | 2025 | β |
| Prognostic significance and pathogenesis of RFC3 gene expression in diffuse large B-cell lymphoma. | Tian Z et al. | β | 2025 | β |
| Promoter Hypomethylation Unleashes HMGA1 to Orchestrate Immune Evasion and Therapy Resistance Across Cancers. | Shahzadi I et al. | β | 2025 | β |
| Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Modulating the cold tumor microenvironment. | Nair SS et al. | β | 2025 | β |
| Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival. | Xie J et al. | β | 2025 | β |
| Proteins linked to type II interferon response in SjΓΆgren's disease: novel indicators for disease monitoring and predicting treatment response to leflunomide and hydroxychloroquine combination therapy. | Wong WY et al. | β | 2025 | β |
| Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma. | Qu Y et al. | β | 2025 | β |
| Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention. | Yarmolinsky J et al. | β | 2025 | β |
| Proteomics analysis reveals progesterone receptor induced mitochondria-mediated apoptosis in breast cancer cells. | Woo QY et al. | β | 2025 | β |
| PSMB9 Orchestrates Tumor Immune Landscape and Serves as a Potent Biomarker for Prognosis and T Cell-Based Immunotherapy Response. | Ma X et al. | β | 2025 | β |
| Pyroptosis-Related Genes as Prognostic Biomarkers and Immune Infiltration Features in Sepsis-Induced ARDS: A Single-Cell and Bulk RNA-Sequencing Analysis. | Zhang P et al. | β | 2025 | β |
| Quantifying Early-Stage Lung Adenocarcinoma Progression with a Radiomic Trajectory. | Qiu ZB et al. | β | 2025 | β |
| Quantifying replication stress in cancer without proliferation confounding. | Jungk P et al. | β | 2025 | β |
| Radiotranscriptomics in papillary thyroid carcinoma complement current noninvasive risk stratification system. | Seo DH et al. | β | 2025 | β |
| Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients. | Leaf DE et al. | β | 2025 | β |
| Rapid cyclic stretching of cultured human visceral smooth muscle cells promotes a synthetic, proinflammatory phenotype. | Wolfson SM et al. | β | 2025 | β |
| Reactive oxygen species-associated molecular landscape uncovers diagnostic and immune features in osteoarthritis. | Zhou J et al. | β | 2025 | β |
| Reduced Expression of Selected Exosomal MicroRNAs Is Associated with Poor Outcomes in Patients with Acute Stroke Receiving Reperfusion Therapy-Preliminary Study. | Gendosz de Carrillo D et al. | β | 2025 | β |
| Reference-guided computational framework identifies microenvironment metabolic subtypes and targets using pan-cancer single-cell datasets. | Tang K et al. | β | 2025 | β |
| Regulation of feather length: FGF/IGF signaling and NOTCH/YAP modulation of progenitor cell topology. | Wu P et al. | β | 2025 | β |
| Regulatory Mechanisms of SPARC Overexpression in Melanoma Progression. | Vinyals A et al. | β | 2025 | β |
| Reprogramming neuroblastoma by diet-enhanced polyamine depletion. | Cherkaoui S et al. | β | 2025 | β |
| Resistance signatures manifested in early drug response across cancer types and species. | Ruoff C et al. | β | 2025 | β |
| Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice. | Gao F et al. | β | 2025 | β |
| Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation. | Leesang TE et al. | β | 2025 | β |
| Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non-genetic Model to Study Hirschsprung Disease? | Kakiailatu NJM et al. | β | 2025 | β |
| Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-ΞΊB, JAK/STAT5 and JNK signalling. | Pastorio C et al. | β | 2025 | β |
| Retrospective analysis of metabolism-related genes in endometrial carcinoma: links to prognosis and immunity. | Lin Q et al. | β | 2025 | β |
| Revealing the Angiogenic Signature of <i>FH</i>-Deficient Breast Cancer: Genomic Profiling and Clinical Implications. | Sinberger LA et al. | β | 2025 | β |
| Revealing the Complexity of Immunobiological Shifts From Non-Pregnant to Pregnant State. | DeBolt CA et al. | β | 2025 | β |
| RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression. | Li J et al. | β | 2025 | β |
| Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer. | Tan L et al. | β | 2025 | β |
| SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer. | Huang M et al. | β | 2025 | β |
| SARS-CoV-2 infection drives local inflammation of the intestinal epithelium in immunocompromised patients with cancer. | Lou E et al. | β | 2025 | β |
| SATB1 is a key regulator of quiescence in stem-like CD8<sup>+</sup> T cells. | Lin S et al. | β | 2025 | β |
| Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells. | Kurishev AO et al. | β | 2025 | β |
| scKAN: interpretable single-cell analysis for cell-type-specific gene discovery and drug repurposing via Kolmogorov-Arnold networks. | He H et al. | β | 2025 | β |
| Screening potential therapeutic drugs for lung adenocarcinoma based on hypoxia and pyrimidine metabolism models. | Sun K et al. | β | 2025 | β |
| scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFΞ± and TGFΞ² in post-COVID syndrome. | Reddy KD et al. | β | 2025 | β |
| Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis. | Wiley AM et al. | β | 2025 | β |
| Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma. | Umbaugh CS et al. | β | 2025 | β |
| Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma. | Huang H et al. | β | 2025 | β |
| Sequential Inflammatory and Matrisome Programs Drive Remodeling of the Mouse Carotid-Jugular Arteriovenous Fistula. | Stoyell-Conti FF et al. | β | 2025 | β |
| Sequential omics analysis reveals molecular signatures of malignant transformation in recurrent meningiomas. | Ohara K et al. | β | 2025 | β |
| Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses. | Ling AL et al. | β | 2025 | β |
| SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis. | Asrani K et al. | β | 2025 | β |
| Sialylation-immune-related lncRNA <i>LINC01605</i> promotes tumor-infiltrating CD8<sup>+</sup> T cell exhaustion and malignancy of clear cell renal cell carcinoma. | Dai Z et al. | β | 2025 | β |
| Signature of leukemia stem cell death pattern predicts prognosis and therapeutic response of acute myeloid leukemia patients. | Wang F et al. | β | 2025 | β |
| Significance of SUMOylation in breast cancer progression: a comprehensive investigation using single-cell analysis and bioinformatics. | He W et al. | β | 2025 | β |
| Signs of immune dysregulation in second-trimester maternal blood RNA profiles in late-onset preeclampsia. | Gunaydin GY et al. | β | 2025 | β |
| Silva pattern-guided proteomics reveals coordinated tumor-stroma remodeling in cervical adenocarcinoma. | Drayer SM et al. | β | 2025 | β |
| Single-cell analysis of heterogeneity and molecular changes in cultured corneal epithelial stem cells during serial passage. | Reinprayoon U et al. | β | 2025 | β |
| Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment. | Gort-Freitas NA et al. | β | 2025 | β |
| Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma. | Chen W et al. | β | 2025 | β |
| Single-cell and spatial transcriptomic characterization of pulmonary pleomorphic carcinoma. | Matsuoka A et al. | β | 2025 | β |
| Single-cell aneuploidy and chromosomal arm imbalances define subclones with divergent transcriptomic phenotypes. | Bai X et al. | β | 2025 | β |
| Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1<sup>+</sup> macrophage activation. | Turiel G et al. | β | 2025 | β |
| Single-cell landscape of sex-specific drivers of Alzheimer's disease. | Wu Y et al. | β | 2025 | β |
| Single-cell mapping of alternative splicing linked to checkpoint immunotherapy response. | Xiong J et al. | β | 2025 | β |
| Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients. | Wang J et al. | β | 2025 | β |
| Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features. | Yu Z et al. | β | 2025 | β |
| Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma. | Veo B et al. | β | 2025 | β |
| Single-cell resolution mapping of the immune modulation landscape induced by Chinese herb sanguisorbae radix. | Guo D et al. | β | 2025 | β |
| Single-cell RNA profiling of colorectal granular-type laterally spreading tumor uncovers progression trajectory toward carcinoma and transcriptional signatures favoring lateral morphogenesis. | Gong Y et al. | β | 2025 | β |
| Single-cell RNA profiling reveals an immunosuppressive microenvironment in <i>EGFR</i> double-mutant non-small cell lung cancer. | Yang J et al. | β | 2025 | β |
| Single-cell RNA sequencing highlights the role of epithelial-immune dual features of proximal tubule cells in BK polyomavirus nephropathy. | Yang F et al. | β | 2025 | β |
| Single-cell RNA sequencing reveals cell immune status and dysregulated monocytes in patients with myasthenia gravis. | Guo Y et al. | β | 2025 | β |
| Single-cell RNA sequencing reveals that kimchi dietary intervention modulates human antigen-presenting and CD4βΊ T cells. | Lee W et al. | β | 2025 | β |
| Single-cell transcriptional profiling revealed the protective effects of Buddleoside in sepsis-associated acute liver injury. | Shi Q et al. | β | 2025 | β |
| Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder. | Zhang Y et al. | β | 2025 | β |
| Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association. | Wizel A et al. | β | 2025 | β |
| Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus. | Yin X et al. | β | 2025 | β |
| Single-cell transcriptomic analysis reveals immune remodeling in bone marrow during aged sepsis. | Lin Y et al. | β | 2025 | β |
| Single-cell transcriptomic landscape of keratinocyte transformation from actinic keratosis to skin carcinoma. | Xu T et al. | β | 2025 | β |
| Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus. | Liu L et al. | β | 2025 | β |
| SLC11A1 protein as a key regulator of iron metabolism, ferroptosis mediator, and putative therapeutic target in nonalcoholic fatty liver disease: an integrated bioinformatics analysis. | Wang Y et al. | β | 2025 | β |
| SLC25A3 promotes hepatocellular carcinoma progression by inducing mitochondrial dysfunction and chromatin remodeling. | Deng S et al. | β | 2025 | β |
| SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study. | D'Addabbo P et al. | β | 2025 | β |
| SMTdb: A Comprehensive Spatial Meta-Transcriptome Resource in Cancer. | Zhou W et al. | β | 2025 | β |
| Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells. | McCastlain K et al. | β | 2025 | β |
| Somatic mutations in IRE1Ξ± regulate keratinocyte migration and survival by differentially activating Rho GTPases. | Mogre S et al. | β | 2025 | β |
| Space radiation induces distinct senescent phenotypes: Implications for space travel. | Pitcher LE et al. | β | 2025 | β |
| Spatial Myeloid Landscape of Large Artery Atherosclerotic and Cardioembolic Thrombi Retrieved by Mechanical Thrombectomy. | Jo S et al. | β | 2025 | β |
| Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion. | Bell ATF et al. | β | 2025 | β |
| Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity. | Han Y et al. | β | 2025 | β |
| Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease. | Sultana Z et al. | β | 2025 | β |
| SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program. | Ly J et al. | β | 2025 | β |
| Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma. | Gao M et al. | β | 2025 | β |
| Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization. | Cavalca G et al. | β | 2025 | β |
| Stromal fibroblastic mutant Trp53 promotes mammary tumor development via enhanced secretion of paracrine factors. | Liu B et al. | β | 2025 | β |
| Strong Transcriptional Signature of Mesenchymal Stromal Cells from Perinatal Tissues Compared with Adult Bone Marrow Sources Independent of Donors or Culture Conditions. | Desterke C et al. | β | 2025 | β |
| Subpopulation-specific apoptotic responses of hemocytes to decapod iridescent virus 1 in Macrobrachium rosenbergii. | Kang F et al. | β | 2025 | β |
| Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities. | Knisely A et al. | β | 2025 | β |
| SWI/SNF Functions as a Gatekeeper of Enhancer Chromatin Access to Control Progression of Mesenchymal Triple-Negative Breast Cancer. | MΓΈldrup RIJ et al. | β | 2025 | β |
| Syntaxin-7 promotes EMT and tumor progression via NF-ΞΊB signaling and is associated with macrophage infiltration: pan-cancer analysis and experimental validation in hepatocellular carcinoma. | Lei L et al. | β | 2025 | β |
| Synthetic lethality of EZH2 and DNMT Inhibition suppresses neuroblastoma proliferation via MYCN destabilization. | Endo Y et al. | β | 2025 | β |
| Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination. | Von Ranke NL et al. | β | 2025 | β |
| System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells. | Medina EF et al. | β | 2025 | β |
| Systematic identification of regions where DNA methylation is correlated with transcription refines regulatory logic in normal and tumour tissues. | Heery R et al. | β | 2025 | β |
| Systems Biology-Based Drug Repositioning Identifies Extracellular Matrix Module as a Therapeutic Target in Lung Squamous Cell Carcinoma. | Yang B et al. | β | 2025 | β |
| Targeting ARPC1B <sup>+</sup> Cancer Stem Cells to Sensitise Pancreatic Cancer to Gemcitabine Treatment. | Wu Y et al. | β | 2025 | β |
| Targeting ATR offers multifaceted treatment strategies involving RAD51-mediated compensatory DNA repair in bladder cancer. | Pannhausen J et al. | β | 2025 | β |
| Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors. | Singh S et al. | β | 2025 | β |
| Targeting high-risk MYC-overexpressed osteosarcoma with an Aurora kinase inhibitor:--results from a pilot umbrella trial. | Tian K et al. | β | 2025 | β |
| Targeting insulin receptor substrate-1 delays disease progression in a murine model of aniridia-associated keratopathy. | Dashti A et al. | β | 2025 | β |
| Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression. | Tcyganov EN et al. | β | 2025 | β |
| Targeting MAT2A synergistically induces DNA damage in osteosarcoma cells through EZH2-mediated H3K27me3 modification. | Yang B et al. | β | 2025 | β |
| Targeting MORF4L1-mediated DNA repair potentiates RT-induced antitumor immunity via cGAS-STING activation in hepatocellular carcinoma. | Wang SW et al. | β | 2025 | β |
| Targeting peroxiredoxin 2 prevents hepatocarcinogenesis in metabolic liver disease models. | Crouchet E et al. | β | 2025 | β |
| Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration. | Gandelman M et al. | β | 2025 | β |
| Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models. | Ott CA et al. | β | 2025 | β |
| TELO2 mediates parabens-induced breast carcinogenesis: a comprehensive network analysis. | Ren J et al. | β | 2025 | β |
| Telomere Length and Clear Cell Renal Cell Carcinoma: Unraveling Causal Mechanisms Through Integrative Genetic and Single-Cell Transcriptomic Analysis. | Zhang K et al. | β | 2025 | β |
| TGF-Ξ²1 promotes collagen synthesis in systemic sclerosis via upregulating P4HA3. | Chen Z et al. | β | 2025 | β |
| TGF-Ξ²-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation. | Jia J | β | 2025 | β |
| The AML cellular state space unveils NPM1 immune evasion subtypes with distinct clinical outcomes. | LilljebjΓΆrn H et al. | β | 2025 | β |
| The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor Ξ±3, Ξ±5, and Ξ±7 Subunits in Oral Squamous Cell Carcinoma. | Lin CM et al. | β | 2025 | β |
| The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1. | Mao F et al. | β | 2025 | β |
| The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells. | Lee I et al. | β | 2025 | β |
| The C-Terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2. | Zingg D et al. | β | 2025 | β |
| The downregulation of ubiquitin-specific peptidase 2 indicates a poor prognosis and promotes the progression of gastric cancer through focal adhesion and ECM pathway signaling. | Liu Y et al. | β | 2025 | β |
| The Dynamic UPR Rheostat Orchestrates Single-Cell Plasticity in Glioblastoma. | Duzgun Z | β | 2025 | β |
| The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage. | Efthymiou G et al. | β | 2025 | β |
| The Genetic Architecture of the Human Corpus Callosum and its Subregions. | Bhatt RR et al. | β | 2025 | β |
| The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture. | Mehnert AK et al. | β | 2025 | β |
| The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells. | Liu H et al. | β | 2025 | β |
| The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration. | GΓΆttert S et al. | β | 2025 | β |
| The molecular cartography of malignant and benign sebaceous tumours. | Ferreira I et al. | β | 2025 | β |
| The nonsteroidal anti-inflammatory drug sulindac reverses obesity-driven immunosuppression and triple-negative breast cancer progression. | Coleman MF et al. | β | 2025 | β |
| The Role of Plasmacytoid Dendritic Cells in the Immune Contexture of <i>TP53</i>-Mutated High-Grade Serous Ovarian Cancer. | Steger K et al. | β | 2025 | β |
| The role of TEAD4 gene in the Hippo signaling pathway in triple-negative breast cancer and targeted therapy strategies. | Zhang X et al. | β | 2025 | β |
| Thrombopoietin increases susceptibility for EVI1β+βKMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome. | ChΓ’tel-Soulet HΓ et al. | β | 2025 | β |
| Time-course transcriptomics reveals the impact of <i>Treponema pallidum</i> on microvascular endothelial cell function and phenotype. | Waugh S et al. | β | 2025 | β |
| TIMP1 as a context-dependent biomarker linking cancer progression and cardiovascular disorders: a multi-level and bioinformatics study. | Xie H et al. | β | 2025 | β |
| Transcriptional and temporal heterogeneity of developing Ξ± cells revealed by single-cell RNA sequencing. | Shimizu N et al. | β | 2025 | β |
| Transcriptional network analysis of PTEN-protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication. | Rondon-Lorefice I et al. | β | 2025 | β |
| Transcription factor Zfx regulates tumor's evasion to T cell killing in immunotherapy. | Kaufmann U et al. | β | 2025 | β |
| Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment. | Yin Q et al. | β | 2025 | β |
| Transcriptome analysis of classical blood cells reveals downregulation of pro-inflammatory genes in the classical monocytes of long COVID patients. | Fricke F et al. | β | 2025 | β |
| Transcriptome Transformer: improving patient survival prediction via multitask learning of transcriptomic and clinical features. | Koo B et al. | β | 2025 | β |
| Transcriptomic analysis identifies a potential target for bevacizumab resistant glioblastoma. | Lodha R et al. | β | 2025 | β |
| Transcriptomic and experimental evidence confirm the potential of disulfidptosis-related signature for the early diagnosis and treatment of liver cirrhosis. | Liu Y et al. | β | 2025 | β |
| Transcriptomic insights into GSDME-driven pyroptosis in head and neck cancer. | Hao F et al. | β | 2025 | β |
| Transcriptomic landscape of generalized pustular psoriasis before and after acitretin/glucocorticoids treatment. | Shen S et al. | β | 2025 | β |
| Transcriptomic profiles of endocrine-resistant breast cancer. | Schagerholm Stanev C et al. | β | 2025 | β |
| Transcriptomic Profiling of the Tumor Immune Microenvironment Reveals Prognostic Markers in mCRPC Patients Treated with LuPSMA Therapy. | Handke A et al. | β | 2025 | β |
| Transcriptomics combined with <i>in vitro</i> experimental validation probes polyamine metabolic profiles in low-grade gliomas. | Pan L et al. | β | 2025 | β |
| Translational investigations in the HN1901 phase II window-of-opportunity study investigating the biological activity of an IDO1 (IO102) and PD-L1 (IO103) immune-modulatory peptide cancer vaccines in squamous cell carcinoma of the head and neck. | Beyaert S et al. | β | 2025 | β |
| TRAP seq in 3D angiogenesis assays reveals a distinct endothelial translatome associated with early and late stages of morphogenesis. | King S et al. | β | 2025 | β |
| Tulp3 deficiency results in ciliopathy phenotypes during zebrafish embryogenesis. | Epting D et al. | β | 2025 | β |
| Tumoral ALOX5 mediated arachidonic acid metabolism regulates immune response in non-small cell lung cancer. | Gao Y et al. | β | 2025 | β |
| Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma. | Wan H et al. | β | 2025 | β |
| Tumors hijack macrophages for iron supply to promote bone metastasis and anemia. | Han Y et al. | β | 2025 | β |
| Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers. | Grist E et al. | β | 2025 | β |
| Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma. | Yong C et al. | β | 2025 | β |
| Two Cohorts, One Network: Consensus Master Regulators Orchestrating Papillary Thyroid Carcinoma. | Tapia-Carrillo D et al. | β | 2025 | β |
| Ubiquitination-activated TAB-TAK1-IKK-NF-ΞΊB axis modulates gene expression for cell survival in the lysosomal damage response. | Endo A et al. | β | 2025 | β |
| Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing. | Zhang W et al. | β | 2025 | β |
| Uncovering Cellular Interactome Drivers of Immune Checkpoint Inhibitor Response in Advanced Melanoma Patients. | Ladd S et al. | β | 2025 | β |
| Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting. | Doncheva NT et al. | β | 2025 | β |
| Unraveling Relatlimab-Specific Biology Using Biomarker Analyses in Patients with Advanced Melanoma in RELATIVITY-047. | Lipson EJ et al. | β | 2025 | β |
| Unraveling Resistance Mechanisms to GΞ±q Pathway Inhibition in Uveal Melanoma: Insights from Signaling-Activation Library Screening. | Lubrano S et al. | β | 2025 | β |
| Unraveling the Clinical and Molecular Landscape of Myocardial Infarction in BehΓ§et's Syndrome: A Comprehensive Analysis. | Zhang LY et al. | β | 2025 | β |
| Unveiling the IL-1Ξ²/CXCL2 axis: a shared therapeutic target in periodontitis and inflammatory bowel disease. | Gu Z et al. | β | 2025 | β |
| Unveiling the prognostic and immunological role of IFI44 in glioma. | Jin D et al. | β | 2025 | β |
| Upfront whole blood transcriptional patterns in patients receiving immune checkpoint inhibitors associate with clinical outcome. | Hone Lopez S et al. | β | 2025 | β |
| Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis. | Fonfara KE et al. | β | 2025 | β |
| Using buccal methylomic data to create explainable aging clocks as well as classifiers and regressors for lifestyle and demographic factors. | Shokhirev MN et al. | β | 2025 | β |
| Using gene-environment interactions to explore pathways for colorectal cancer risk. | Bouras E et al. | β | 2025 | β |
| Vaccination against Onchocerca volvulus induces IgG-mediated protective immunity dependent on neutrophils and complement. | Ryan NM et al. | β | 2025 | β |
| VEGF Signal Complexity Confers Resistance to Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in EGFR-Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer. | Hong S et al. | β | 2025 | β |
| VΞ³9VΞ΄2 T Cells Express an Antitumor Profile Associated with Anti-PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer. | Fattori S et al. | β | 2025 | β |
| Wharton's jelly-derived nanovesicles for targeting intervertebral disc degeneration. | Penolazzi L et al. | β | 2025 | β |
| Whole genome sequencing reveals telomere associated genomic differences between healthy and unhealthy aging in a Korean population. | Oh JH et al. | β | 2025 | β |
| YRDC is a Prognostic-Related Biomarker Correlated With Immune Infiltration and Drug Sensitivity in Pan-Cancer. | Qiao L et al. | β | 2025 | β |
| Zonal endothelial cell heterogeneity underlies murine renal vascular development. | Luo PM et al. | β | 2025 | β |