The top five SNPs for the transition between daily smoking and cessation are presented in Table 3. In the time‐to‐event analysis rs72779075 on 10p14 showed genome‐wide significant association (P = 4.47e‐08) (Fig. S9, Table 3) with an HR of 1.48, suggesting that carriers of the minor allele quit earlier than noncarriers. In a follow‐up analysis additionally adjusted for FTND and DSM‐IV nicotine withdrawal symptom score, rs72779075 remained as the top SNP but the signal no longer was significant (Fig. S10, Table 3). This locus is close to a pseudogene RP11‐575N15 (with a distance of <40 kb), and the nearest gene is GATA3 (725 kb apart). A regional plot of the 10p14 locus is shown in Figure S11. In an analysis conditioned on rs72779075, no residual genome‐wide significant signal remained, suggesting that there is only one independent signal in this locus. None of the top five SNPs replicated in an independent Australian twin family sample, nor did any SNPs located within GATA3. Meta‐analysis of the top five SNPs did not yield genome‐wide statistically significant signals.
